Gram-negative multidrug-resistant organisms were dominant in neurorehabilitation ward patients in a general hospital in southwest China
Abstract This study aimed to investigate the prevalence of and risk factors for multidrug-resistant organism (MDRO) infection in the rehabilitation ward of a general hospital in Southwest China. We analyzed rehabilitation patients with nosocomial infections caused by MDROs from June 2016 to June 202...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-15397-y |
| _version_ | 1811328823299407872 |
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| author | Wei Jiang Lang Li Siyang Wen Yunling Song Lehua yu Botao Tan |
| author_facet | Wei Jiang Lang Li Siyang Wen Yunling Song Lehua yu Botao Tan |
| author_sort | Wei Jiang |
| collection | DOAJ |
| description | Abstract This study aimed to investigate the prevalence of and risk factors for multidrug-resistant organism (MDRO) infection in the rehabilitation ward of a general hospital in Southwest China. We analyzed rehabilitation patients with nosocomial infections caused by MDROs from June 2016 to June 2020. MDRO infection pathogens and associated antibiotic resistance were calculated. Possible risk factors for MDRO-related infection in the neurorehabilitation ward were analyzed using chi-square, and logistic regression. A total of 112 strains of MDRO were found positive from 96 patients. The MDRO test-positive rate was 16.70% (96/575). Ninety-five MDRO strains were detected in sputum, of which 84.82% (95/112) were gram-negative bacteria. Acinetobacter baumannii (A. Baumannii), Pseudomonas aeruginosa (P. aeruginosa), and Klebsiella pneumonia (K. pneumonia) were the most frequently isolated MDRO strains. The logistic regression model and multifactorial analysis showed that long-term (≥ 7 days) antibiotic use (OR 6.901), history of tracheotomy (OR 4.458), and a low albumin level (< 40 g/L) (OR 2.749) were independent risk factors for the development of MDRO infection in patients in the rehabilitation ward (all P < 0.05). Gram-negative MRDOs were dominant in rehabilitation ward patients. Low albumin, history of a tracheostomy, and long-term use of antibiotics were independent risk factors for MRDO infection and are worthy of attention. |
| first_indexed | 2024-04-13T15:31:48Z |
| format | Article |
| id | doaj.art-1e9f189263184e14b4562177ee5a8505 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T15:31:48Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-1e9f189263184e14b4562177ee5a85052022-12-22T02:41:21ZengNature PortfolioScientific Reports2045-23222022-06-011211810.1038/s41598-022-15397-yGram-negative multidrug-resistant organisms were dominant in neurorehabilitation ward patients in a general hospital in southwest ChinaWei Jiang0Lang Li1Siyang Wen2Yunling Song3Lehua yu4Botao Tan5Department of Rehabilitation Medicine, The Second Affiliated Hospital of Chongqing Medical UniversityDepartment of Rehabilitation Medicine, The Second Affiliated Hospital of Chongqing Medical UniversityDepartment of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical UniversityDepartment of Rehabilitation Medicine, The Second Affiliated Hospital of Chongqing Medical UniversityDepartment of Rehabilitation Medicine, The Second Affiliated Hospital of Chongqing Medical UniversityDepartment of Rehabilitation Medicine, The Second Affiliated Hospital of Chongqing Medical UniversityAbstract This study aimed to investigate the prevalence of and risk factors for multidrug-resistant organism (MDRO) infection in the rehabilitation ward of a general hospital in Southwest China. We analyzed rehabilitation patients with nosocomial infections caused by MDROs from June 2016 to June 2020. MDRO infection pathogens and associated antibiotic resistance were calculated. Possible risk factors for MDRO-related infection in the neurorehabilitation ward were analyzed using chi-square, and logistic regression. A total of 112 strains of MDRO were found positive from 96 patients. The MDRO test-positive rate was 16.70% (96/575). Ninety-five MDRO strains were detected in sputum, of which 84.82% (95/112) were gram-negative bacteria. Acinetobacter baumannii (A. Baumannii), Pseudomonas aeruginosa (P. aeruginosa), and Klebsiella pneumonia (K. pneumonia) were the most frequently isolated MDRO strains. The logistic regression model and multifactorial analysis showed that long-term (≥ 7 days) antibiotic use (OR 6.901), history of tracheotomy (OR 4.458), and a low albumin level (< 40 g/L) (OR 2.749) were independent risk factors for the development of MDRO infection in patients in the rehabilitation ward (all P < 0.05). Gram-negative MRDOs were dominant in rehabilitation ward patients. Low albumin, history of a tracheostomy, and long-term use of antibiotics were independent risk factors for MRDO infection and are worthy of attention.https://doi.org/10.1038/s41598-022-15397-y |
| spellingShingle | Wei Jiang Lang Li Siyang Wen Yunling Song Lehua yu Botao Tan Gram-negative multidrug-resistant organisms were dominant in neurorehabilitation ward patients in a general hospital in southwest China Scientific Reports |
| title | Gram-negative multidrug-resistant organisms were dominant in neurorehabilitation ward patients in a general hospital in southwest China |
| title_full | Gram-negative multidrug-resistant organisms were dominant in neurorehabilitation ward patients in a general hospital in southwest China |
| title_fullStr | Gram-negative multidrug-resistant organisms were dominant in neurorehabilitation ward patients in a general hospital in southwest China |
| title_full_unstemmed | Gram-negative multidrug-resistant organisms were dominant in neurorehabilitation ward patients in a general hospital in southwest China |
| title_short | Gram-negative multidrug-resistant organisms were dominant in neurorehabilitation ward patients in a general hospital in southwest China |
| title_sort | gram negative multidrug resistant organisms were dominant in neurorehabilitation ward patients in a general hospital in southwest china |
| url | https://doi.org/10.1038/s41598-022-15397-y |
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