Permeation of Silver Sulfadiazine Into TEMPO-Oxidized Bacterial Cellulose as an Antibacterial Agent
Surface oxidation of bacterial cellulose (BC) was done with the TEMPO-mediated oxidation mechanism system. After that, TEMPO-oxidized bacterial cellulose (TOBC) was impregnated with silver sulfadiazine (AgSD) to prepare nanocomposite membranes. Fourier transform infrared spectroscopy (FTIR) was carr...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2020.616467/full |
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| author | Shahia Khattak Shahia Khattak Xiao-Tong Qin Xiao-Tong Qin Fazli Wahid Fazli Wahid Long-Hui Huang Long-Hui Huang Yan-Yan Xie Yan-Yan Xie Shi-Ru Jia Shi-Ru Jia Cheng Zhong Cheng Zhong |
| author_facet | Shahia Khattak Shahia Khattak Xiao-Tong Qin Xiao-Tong Qin Fazli Wahid Fazli Wahid Long-Hui Huang Long-Hui Huang Yan-Yan Xie Yan-Yan Xie Shi-Ru Jia Shi-Ru Jia Cheng Zhong Cheng Zhong |
| author_sort | Shahia Khattak |
| collection | DOAJ |
| description | Surface oxidation of bacterial cellulose (BC) was done with the TEMPO-mediated oxidation mechanism system. After that, TEMPO-oxidized bacterial cellulose (TOBC) was impregnated with silver sulfadiazine (AgSD) to prepare nanocomposite membranes. Fourier transform infrared spectroscopy (FTIR) was carried out to determine the existence of aldehyde groups on BC nanofibers and X-ray diffraction (XRD) demonstrated the degree of crystallinity. FESEM analysis revealed the impregnation of AgSD nanoparticles at TOBC nanocomposites with the average diameter size ranging from 11 nm to 17.5 nm. The sample OBCS3 showed higher antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli by the disc diffusion method. The results showed AgSD content, dependent antibacterial activity against all tested bacteria, and degree of crystallinity increases with TOBC and AgSD. The main advantage of the applications of TEMPO-mediated oxidation to BC nanofibers is that the crystallinity of BC nanofibers is unchanged and increased after the oxidation. Also enhanced the reactivity of BC as it is one of the most promising method for cellulose fabrication and functionalization. We believe that the novel composite membrane could be a potential candidate for biomedical applications like wound dressing, BC scaffold, and tissue engineering. |
| first_indexed | 2024-12-17T08:48:22Z |
| format | Article |
| id | doaj.art-1ea118ea302d422e8409f3f2bd05b80c |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-17T08:48:22Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-1ea118ea302d422e8409f3f2bd05b80c2022-12-21T21:56:08ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852021-01-01810.3389/fbioe.2020.616467616467Permeation of Silver Sulfadiazine Into TEMPO-Oxidized Bacterial Cellulose as an Antibacterial AgentShahia Khattak0Shahia Khattak1Xiao-Tong Qin2Xiao-Tong Qin3Fazli Wahid4Fazli Wahid5Long-Hui Huang6Long-Hui Huang7Yan-Yan Xie8Yan-Yan Xie9Shi-Ru Jia10Shi-Ru Jia11Cheng Zhong12Cheng Zhong13State Key Laboratory of Food Nutrition & Safety, Tianjin University of Science & Technology, Tianjin, ChinaKey Laboratory of Industrial Fermentation Microbiology, (Ministry of Education), Tianjin University of Science & Technology, Tianjin, ChinaState Key Laboratory of Food Nutrition & Safety, Tianjin University of Science & Technology, Tianjin, ChinaKey Laboratory of Industrial Fermentation Microbiology, (Ministry of Education), Tianjin University of Science & Technology, Tianjin, ChinaState Key Laboratory of Food Nutrition & Safety, Tianjin University of Science & Technology, Tianjin, ChinaKey Laboratory of Industrial Fermentation Microbiology, (Ministry of Education), Tianjin University of Science & Technology, Tianjin, ChinaState Key Laboratory of Food Nutrition & Safety, Tianjin University of Science & Technology, Tianjin, ChinaKey Laboratory of Industrial Fermentation Microbiology, (Ministry of Education), Tianjin University of Science & Technology, Tianjin, ChinaState Key Laboratory of Food Nutrition & Safety, Tianjin University of Science & Technology, Tianjin, ChinaKey Laboratory of Industrial Fermentation Microbiology, (Ministry of Education), Tianjin University of Science & Technology, Tianjin, ChinaState Key Laboratory of Food Nutrition & Safety, Tianjin University of Science & Technology, Tianjin, ChinaKey Laboratory of Industrial Fermentation Microbiology, (Ministry of Education), Tianjin University of Science & Technology, Tianjin, ChinaState Key Laboratory of Food Nutrition & Safety, Tianjin University of Science & Technology, Tianjin, ChinaKey Laboratory of Industrial Fermentation Microbiology, (Ministry of Education), Tianjin University of Science & Technology, Tianjin, ChinaSurface oxidation of bacterial cellulose (BC) was done with the TEMPO-mediated oxidation mechanism system. After that, TEMPO-oxidized bacterial cellulose (TOBC) was impregnated with silver sulfadiazine (AgSD) to prepare nanocomposite membranes. Fourier transform infrared spectroscopy (FTIR) was carried out to determine the existence of aldehyde groups on BC nanofibers and X-ray diffraction (XRD) demonstrated the degree of crystallinity. FESEM analysis revealed the impregnation of AgSD nanoparticles at TOBC nanocomposites with the average diameter size ranging from 11 nm to 17.5 nm. The sample OBCS3 showed higher antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli by the disc diffusion method. The results showed AgSD content, dependent antibacterial activity against all tested bacteria, and degree of crystallinity increases with TOBC and AgSD. The main advantage of the applications of TEMPO-mediated oxidation to BC nanofibers is that the crystallinity of BC nanofibers is unchanged and increased after the oxidation. Also enhanced the reactivity of BC as it is one of the most promising method for cellulose fabrication and functionalization. We believe that the novel composite membrane could be a potential candidate for biomedical applications like wound dressing, BC scaffold, and tissue engineering.https://www.frontiersin.org/articles/10.3389/fbioe.2020.616467/fullsilver sulfadiazinebacterial celluloseTEMPO-oxidationantibacterial activitynanocomposites |
| spellingShingle | Shahia Khattak Shahia Khattak Xiao-Tong Qin Xiao-Tong Qin Fazli Wahid Fazli Wahid Long-Hui Huang Long-Hui Huang Yan-Yan Xie Yan-Yan Xie Shi-Ru Jia Shi-Ru Jia Cheng Zhong Cheng Zhong Permeation of Silver Sulfadiazine Into TEMPO-Oxidized Bacterial Cellulose as an Antibacterial Agent Frontiers in Bioengineering and Biotechnology silver sulfadiazine bacterial cellulose TEMPO-oxidation antibacterial activity nanocomposites |
| title | Permeation of Silver Sulfadiazine Into TEMPO-Oxidized Bacterial Cellulose as an Antibacterial Agent |
| title_full | Permeation of Silver Sulfadiazine Into TEMPO-Oxidized Bacterial Cellulose as an Antibacterial Agent |
| title_fullStr | Permeation of Silver Sulfadiazine Into TEMPO-Oxidized Bacterial Cellulose as an Antibacterial Agent |
| title_full_unstemmed | Permeation of Silver Sulfadiazine Into TEMPO-Oxidized Bacterial Cellulose as an Antibacterial Agent |
| title_short | Permeation of Silver Sulfadiazine Into TEMPO-Oxidized Bacterial Cellulose as an Antibacterial Agent |
| title_sort | permeation of silver sulfadiazine into tempo oxidized bacterial cellulose as an antibacterial agent |
| topic | silver sulfadiazine bacterial cellulose TEMPO-oxidation antibacterial activity nanocomposites |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2020.616467/full |
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