Silencing of CD147 inhibits cell proliferation, migration, invasion, lipid metabolism dysregulation and promotes apoptosis in lung adenocarcinoma via blocking the Rap1 signaling pathway

Silencing of CD147 inhibits cell proliferation, migration, invasion, lipid metabolism dysregulation and promotes apoptosis in lung adenocarcinoma via blocking the Rap1 signaling pathway

Abstract Objective CD147 is an important glycoprotein that participates in the progression of diverse cancers. This study aims to explore the specific function of CD147 in lung adenocarcinoma (LUAD) and to reveal related downstream molecular mechanisms. Methods Followed by silencing of CD147, the vi...

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Bibliographic Details
Main Authors: Ning Zhang, Zhouzhong Liu, Xuwang Lai, Shubin Liu, Yuli Wang
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Respiratory Research
Subjects:
Lung adenocarcinoma
CD147
Transcriptome sequencing
Lipid metabolism
Rap1 signaling pathway
Online Access:https://doi.org/10.1186/s12931-023-02532-0

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