Lack of placental neurosteroid alters cortical development and female somatosensory function

Lack of placental neurosteroid alters cortical development and female somatosensory function

Placental endocrine function is essential to fetal brain development. Placental hormones include neurosteroids such as allopregnanolone (ALLO), a regulator of neurodevelopmental processes via positive allosteric modulation of the GABAA receptor (GABAA-R). Using a mouse model (plKO) in which the gene...

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Bibliographic Details
Main Authors: Dana Bakalar, Jiaqi J. O’Reilly, Helene Lacaille, Jacquelyn Salzbank, Jacob Ellegood, Jason P. Lerch, Toru Sasaki, Yuka Imamura, Kazue Hashimoto-Torii, Claire-Marie Vacher, Anna A. Penn
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Endocrinology
Subjects:
neuroplacentology
allopregnanolone (3α,5α-THP)
somatosensory cortex (S1)
placenta
postmortem human brain
preterm birth
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.972033/full

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