A pH-Responsive Zwitterionic Polyurethane Prodrug as Drug Delivery System for Enhanced Cancer Therapy
Numerous nanocarriers with excellent biocompatibilities have been used to improve cancer therapy. However, nonspecific protein adsorption of nanocarriers may block the modified nanoparticles in tumor cells, which would lead to inefficient cellular internalization. To address this issue, pH-responsiv...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/17/5274 |
| _version_ | 1797521007582380032 |
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| author | Qian He Rui Yan Wanting Hou Haibo Wang Yali Tian |
| author_facet | Qian He Rui Yan Wanting Hou Haibo Wang Yali Tian |
| author_sort | Qian He |
| collection | DOAJ |
| description | Numerous nanocarriers with excellent biocompatibilities have been used to improve cancer therapy. However, nonspecific protein adsorption of nanocarriers may block the modified nanoparticles in tumor cells, which would lead to inefficient cellular internalization. To address this issue, pH-responsive polyurethane prodrug micelles with a zwitterionic segment were designed and prepared. The micelle consisted of a zwitterionic segment as the hydrophilic shell and the drug Adriamycin (DOX) as the hydrophobic inner core. As a pH-responsive antitumor drug delivery system, the prodrug micelles showed high stability in a physiological environment and continuously released the drug under acidic conditions. In addition, the pure polyurethane carrier was demonstrated to be virtually non-cytotoxic by cytotoxicity studies, while the prodrug micelles were more efficient in killing tumor cells compared to PEG-PLGA@DOX. Furthermore, the DOX cellular uptake efficiency of prodrug micelles was proved to be obviously higher than the control group by both flow cytometry and fluorescence microscopy. This is mainly due to the modification of a zwitterionic segment with PU. The simple design of zwitterionic prodrug micelles provides a new strategy for designing novel antitumor drug delivery systems with enhanced cellular uptake rates. |
| first_indexed | 2024-03-10T08:06:35Z |
| format | Article |
| id | doaj.art-1ea4b28386c6475d9ff81a7342b40339 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T08:06:35Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-1ea4b28386c6475d9ff81a7342b403392023-11-22T11:01:41ZengMDPI AGMolecules1420-30492021-08-012617527410.3390/molecules26175274A pH-Responsive Zwitterionic Polyurethane Prodrug as Drug Delivery System for Enhanced Cancer TherapyQian He0Rui Yan1Wanting Hou2Haibo Wang3Yali Tian4Department of Emergency, West China Hospital, Sichuan University, Guoxue Alley No. 37, Chengdu 610041, ChinaCollege of Biomass Science and Engineering, Sichuan University, Chengdu 610041, ChinaDepartment of Emergency, West China Hospital, Sichuan University, Guoxue Alley No. 37, Chengdu 610041, ChinaCollege of Biomass Science and Engineering, Sichuan University, Chengdu 610041, ChinaWest China School of Nursing, West China Hospital, Sichuan University, Guoxue Alley No. 37, Chengdu 610041, ChinaNumerous nanocarriers with excellent biocompatibilities have been used to improve cancer therapy. However, nonspecific protein adsorption of nanocarriers may block the modified nanoparticles in tumor cells, which would lead to inefficient cellular internalization. To address this issue, pH-responsive polyurethane prodrug micelles with a zwitterionic segment were designed and prepared. The micelle consisted of a zwitterionic segment as the hydrophilic shell and the drug Adriamycin (DOX) as the hydrophobic inner core. As a pH-responsive antitumor drug delivery system, the prodrug micelles showed high stability in a physiological environment and continuously released the drug under acidic conditions. In addition, the pure polyurethane carrier was demonstrated to be virtually non-cytotoxic by cytotoxicity studies, while the prodrug micelles were more efficient in killing tumor cells compared to PEG-PLGA@DOX. Furthermore, the DOX cellular uptake efficiency of prodrug micelles was proved to be obviously higher than the control group by both flow cytometry and fluorescence microscopy. This is mainly due to the modification of a zwitterionic segment with PU. The simple design of zwitterionic prodrug micelles provides a new strategy for designing novel antitumor drug delivery systems with enhanced cellular uptake rates.https://www.mdpi.com/1420-3049/26/17/5274pH-responsive polyurethaneAdriamycinzwitterionicantitumor |
| spellingShingle | Qian He Rui Yan Wanting Hou Haibo Wang Yali Tian A pH-Responsive Zwitterionic Polyurethane Prodrug as Drug Delivery System for Enhanced Cancer Therapy Molecules pH-responsive polyurethane Adriamycin zwitterionic antitumor |
| title | A pH-Responsive Zwitterionic Polyurethane Prodrug as Drug Delivery System for Enhanced Cancer Therapy |
| title_full | A pH-Responsive Zwitterionic Polyurethane Prodrug as Drug Delivery System for Enhanced Cancer Therapy |
| title_fullStr | A pH-Responsive Zwitterionic Polyurethane Prodrug as Drug Delivery System for Enhanced Cancer Therapy |
| title_full_unstemmed | A pH-Responsive Zwitterionic Polyurethane Prodrug as Drug Delivery System for Enhanced Cancer Therapy |
| title_short | A pH-Responsive Zwitterionic Polyurethane Prodrug as Drug Delivery System for Enhanced Cancer Therapy |
| title_sort | ph responsive zwitterionic polyurethane prodrug as drug delivery system for enhanced cancer therapy |
| topic | pH-responsive polyurethane Adriamycin zwitterionic antitumor |
| url | https://www.mdpi.com/1420-3049/26/17/5274 |
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