Low high density lipoprotein cholesterol levels and acute coronary syndrome in young patients admitted at a tertiary care facility
Background: Coronary artery disease (CAD) is a cardiovascular disease which is related to mortality and morbidity among the Indians predominantly in the older age group. But, recently CAD has been found more often in young population. Hence, our study aims to observe the outcomes based on various ca...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Babol University of Medical Sciences
2022-09-01
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| Series: | Caspian Journal of Internal Medicine |
| Subjects: | |
| Online Access: | http://caspjim.com/article-1-2653-en.html |
| _version_ | 1811326688138625024 |
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| author | Arpita Chakraborty CH Sai kumar Mukhyaprana Prabhu Weena Stanley Ranjan Shetty |
| author_facet | Arpita Chakraborty CH Sai kumar Mukhyaprana Prabhu Weena Stanley Ranjan Shetty |
| author_sort | Arpita Chakraborty |
| collection | DOAJ |
| description | Background: Coronary artery disease (CAD) is a cardiovascular disease which is related to mortality and morbidity among the Indians predominantly in the older age group. But, recently CAD has been found more often in young population. Hence, our study aims to observe the outcomes based on various categories of high density lipoprotein (HDL) cholesterol levels estimated during admission at the hospital and correlate the levels of HDL cholesterol with severity of CAD as measured by Gensini score.
Methods: A cross-sectional study was conducted in 151 young patients (18-45 years) who were admitted at the hospital with newly diagnosed acute coronary syndrome (ACS). Tests such as electrocardiogram, cardiac enzyme assay, hematologic and biochemical tests including fasting lipid profile levels were taken into account.
Results: There was an inverse relation observed between the number of vessels involvedand HDL cholesterol levels. Those with lower levels of HDL cholesterol were more vulnerable to multi-vessel CAD. However, no association was observed between HDL cholesterol and severity of CAD as measured by Gensini score.
Conclusion: In young patients with acute coronary syndrome and diminished HDL cholesterol levels had a greater number of vessels involved when compared with elevated HDL cholesterol levels group. However, low HDL cholesterol levels had no association with severity of CAD as measured by Gensini score. No statistically significant association was noticed between levels of HDL cholesterol and in hospital mortality /morbidity. |
| first_indexed | 2024-04-13T14:54:09Z |
| format | Article |
| id | doaj.art-1ea4f555341f4417858cbb7b99237bd0 |
| institution | Directory Open Access Journal |
| issn | 2008-6164 2008-6172 |
| language | English |
| last_indexed | 2024-04-13T14:54:09Z |
| publishDate | 2022-09-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Caspian Journal of Internal Medicine |
| spelling | doaj.art-1ea4f555341f4417858cbb7b99237bd02022-12-22T02:42:30ZengBabol University of Medical SciencesCaspian Journal of Internal Medicine2008-61642008-61722022-09-01134675680Low high density lipoprotein cholesterol levels and acute coronary syndrome in young patients admitted at a tertiary care facilityArpita Chakraborty0CH Sai kumar1Mukhyaprana Prabhu2Weena Stanley3Ranjan Shetty4 Department of General Medicine, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal-576104, Karnataka, India Department of General Medicine, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal-576104, Karnataka, India Department of General Medicine, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal-576104, Karnataka, India Department of General Medicine, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal-576104, Karnataka, India Department of Cardiology, Manipal Hospitals, Bangalore-560017, Karnataka, India Background: Coronary artery disease (CAD) is a cardiovascular disease which is related to mortality and morbidity among the Indians predominantly in the older age group. But, recently CAD has been found more often in young population. Hence, our study aims to observe the outcomes based on various categories of high density lipoprotein (HDL) cholesterol levels estimated during admission at the hospital and correlate the levels of HDL cholesterol with severity of CAD as measured by Gensini score. Methods: A cross-sectional study was conducted in 151 young patients (18-45 years) who were admitted at the hospital with newly diagnosed acute coronary syndrome (ACS). Tests such as electrocardiogram, cardiac enzyme assay, hematologic and biochemical tests including fasting lipid profile levels were taken into account. Results: There was an inverse relation observed between the number of vessels involvedand HDL cholesterol levels. Those with lower levels of HDL cholesterol were more vulnerable to multi-vessel CAD. However, no association was observed between HDL cholesterol and severity of CAD as measured by Gensini score. Conclusion: In young patients with acute coronary syndrome and diminished HDL cholesterol levels had a greater number of vessels involved when compared with elevated HDL cholesterol levels group. However, low HDL cholesterol levels had no association with severity of CAD as measured by Gensini score. No statistically significant association was noticed between levels of HDL cholesterol and in hospital mortality /morbidity.http://caspjim.com/article-1-2653-en.htmlacute coronary syndromecoronary artery diseasehdl cholesterolmyocardial infarctiongensini score |
| spellingShingle | Arpita Chakraborty CH Sai kumar Mukhyaprana Prabhu Weena Stanley Ranjan Shetty Low high density lipoprotein cholesterol levels and acute coronary syndrome in young patients admitted at a tertiary care facility Caspian Journal of Internal Medicine acute coronary syndrome coronary artery disease hdl cholesterol myocardial infarction gensini score |
| title | Low high density lipoprotein cholesterol levels and acute coronary syndrome in young patients admitted at a tertiary care facility |
| title_full | Low high density lipoprotein cholesterol levels and acute coronary syndrome in young patients admitted at a tertiary care facility |
| title_fullStr | Low high density lipoprotein cholesterol levels and acute coronary syndrome in young patients admitted at a tertiary care facility |
| title_full_unstemmed | Low high density lipoprotein cholesterol levels and acute coronary syndrome in young patients admitted at a tertiary care facility |
| title_short | Low high density lipoprotein cholesterol levels and acute coronary syndrome in young patients admitted at a tertiary care facility |
| title_sort | low high density lipoprotein cholesterol levels and acute coronary syndrome in young patients admitted at a tertiary care facility |
| topic | acute coronary syndrome coronary artery disease hdl cholesterol myocardial infarction gensini score |
| url | http://caspjim.com/article-1-2653-en.html |
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