Phenolic acids and quercetin from Korean black raspberry seed protected against acetaminophen-induced oxidative stress in mice
The Korean black raspberry seed extracts are hypothesised to protect against acetaminophen-induced hepatotoxicity. Male mice were divided into five groups: (1) normal treated, (2) APAP-treated, (3) fresh seed extract (FSE) treated, (4) wine-processed seed extract (WSE) treated, and (5) silymarin-tre...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-12-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464615004703 |
| _version_ | 1818936935066894336 |
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| author | Mi-Hee Choi Soon-Mi Shim Gun-Hee Kim |
| author_facet | Mi-Hee Choi Soon-Mi Shim Gun-Hee Kim |
| author_sort | Mi-Hee Choi |
| collection | DOAJ |
| description | The Korean black raspberry seed extracts are hypothesised to protect against acetaminophen-induced hepatotoxicity. Male mice were divided into five groups: (1) normal treated, (2) APAP-treated, (3) fresh seed extract (FSE) treated, (4) wine-processed seed extract (WSE) treated, and (5) silymarin-treated. The amounts of gallic acid (8.23 mg/g extract) and ellagic acid (11.22 mg/g extract) in WSE were significantly higher than those in FSE. Both protocatechuic acid (3.81 mg/g extract) and quercetin (7.41 mg/g extract) were only found in WSE. In both FSE and WSE groups, the activity of AST and ALT significantly decreased, while the antioxidant markers including CAT, SOD, GPx, and GSH were restored in a dose-dependent manner. The inhibition of the oxidative damage to lipid, protein, and DNA by Korean black raspberry seed extract was more effective in WSE than FSE. These results suggest that phenolic acids and quercetin from wine-processed seed could have therapeutic potential in hepatotoxicity. |
| first_indexed | 2024-12-20T05:43:58Z |
| format | Article |
| id | doaj.art-1ea4fa6a5c84462082e54c2c520f1b0d |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-20T05:43:58Z |
| publishDate | 2015-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-1ea4fa6a5c84462082e54c2c520f1b0d2022-12-21T19:51:21ZengElsevierJournal of Functional Foods1756-46462015-12-0119404416Phenolic acids and quercetin from Korean black raspberry seed protected against acetaminophen-induced oxidative stress in miceMi-Hee Choi0Soon-Mi Shim1Gun-Hee Kim2Department of Food Science and Technology, Sejong University, 98 Gunja-dong, Kwangjin-gu, Seoul 134-747, South KoreaDepartment of Food Science and Technology, Sejong University, 98 Gunja-dong, Kwangjin-gu, Seoul 134-747, South Korea; Corresponding author. Department of Food Science and Technology, Sejong University, 98 Gunja-dong, Kwangjin-gu, Seoul 134-747, South Korea. Tel.: +82 2 3408 3229; fax: +82 2 3408 4319.Department of Food and Nutrition, Duksung Women's University, 419 Ssangmun-dong, Tobong-gu, Seoul 132-714, South Korea; Corresponding author. Department of Food and Nutrition, Duksung Women's University, 419 Ssangmun-dong, Tobong-gu, Seoul 132-714, South Korea. Tel.: +82 2 901 8496; fax: +82 2 901 8474.The Korean black raspberry seed extracts are hypothesised to protect against acetaminophen-induced hepatotoxicity. Male mice were divided into five groups: (1) normal treated, (2) APAP-treated, (3) fresh seed extract (FSE) treated, (4) wine-processed seed extract (WSE) treated, and (5) silymarin-treated. The amounts of gallic acid (8.23 mg/g extract) and ellagic acid (11.22 mg/g extract) in WSE were significantly higher than those in FSE. Both protocatechuic acid (3.81 mg/g extract) and quercetin (7.41 mg/g extract) were only found in WSE. In both FSE and WSE groups, the activity of AST and ALT significantly decreased, while the antioxidant markers including CAT, SOD, GPx, and GSH were restored in a dose-dependent manner. The inhibition of the oxidative damage to lipid, protein, and DNA by Korean black raspberry seed extract was more effective in WSE than FSE. These results suggest that phenolic acids and quercetin from wine-processed seed could have therapeutic potential in hepatotoxicity.http://www.sciencedirect.com/science/article/pii/S1756464615004703Korean black raspberry seedHepatotoxicityAcetaminophenAntioxidant enzyme |
| spellingShingle | Mi-Hee Choi Soon-Mi Shim Gun-Hee Kim Phenolic acids and quercetin from Korean black raspberry seed protected against acetaminophen-induced oxidative stress in mice Journal of Functional Foods Korean black raspberry seed Hepatotoxicity Acetaminophen Antioxidant enzyme |
| title | Phenolic acids and quercetin from Korean black raspberry seed protected against acetaminophen-induced oxidative stress in mice |
| title_full | Phenolic acids and quercetin from Korean black raspberry seed protected against acetaminophen-induced oxidative stress in mice |
| title_fullStr | Phenolic acids and quercetin from Korean black raspberry seed protected against acetaminophen-induced oxidative stress in mice |
| title_full_unstemmed | Phenolic acids and quercetin from Korean black raspberry seed protected against acetaminophen-induced oxidative stress in mice |
| title_short | Phenolic acids and quercetin from Korean black raspberry seed protected against acetaminophen-induced oxidative stress in mice |
| title_sort | phenolic acids and quercetin from korean black raspberry seed protected against acetaminophen induced oxidative stress in mice |
| topic | Korean black raspberry seed Hepatotoxicity Acetaminophen Antioxidant enzyme |
| url | http://www.sciencedirect.com/science/article/pii/S1756464615004703 |
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