Biophysical fitness landscapes for transcription factor binding sites.

Biophysical fitness landscapes for transcription factor binding sites.

Phenotypic states and evolutionary trajectories available to cell populations are ultimately dictated by complex interactions among DNA, RNA, proteins, and other molecular species. Here we study how evolution of gene regulation in a single-cell eukaryote S. cerevisiae is affected by interactions bet...

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Bibliographic Details
Main Authors:	Allan Haldane, Michael Manhart, Alexandre V Morozov
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2014-07-01
Series:	PLoS Computational Biology
Online Access:	http://europepmc.org/articles/PMC4091707?pdf=render

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