SARS-CoV-2 and its impact on the cardiovascular and digestive systems – The interplay between new virus variants and human cells
Since infection with the novel coronavirus SARS-CoV-2 first emerged in Wuhan, China, in December 2019, the world has been battling the pandemic COVID-19. Patients of all ages and genders are now becoming infected with the new coronavirus variant (Omicron) worldwide, and its subvariants continue to p...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Computational and Structural Biotechnology Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037023000260 |
| _version_ | 1827577652615053312 |
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| author | Angelika Szpulak Urszula Garlak Hanna Ćwirko Bogusława Witkowska Agnieszka Rombel-Bryzek Danuta Witkowska |
| author_facet | Angelika Szpulak Urszula Garlak Hanna Ćwirko Bogusława Witkowska Agnieszka Rombel-Bryzek Danuta Witkowska |
| author_sort | Angelika Szpulak |
| collection | DOAJ |
| description | Since infection with the novel coronavirus SARS-CoV-2 first emerged in Wuhan, China, in December 2019, the world has been battling the pandemic COVID-19. Patients of all ages and genders are now becoming infected with the new coronavirus variant (Omicron) worldwide, and its subvariants continue to pose a threat to health and life. This article provides a literature review of cardiovascular and gastrointestinal complications resulting from SARS-CoV-2 infection. COVID-19 primarily caused respiratory symptoms, but complications can affect many vital organs. SARS-CoV-2 binds to a human cell receptor (angiotensin-converting enzyme 2 – ACE2) that is predominantly expressed primarily in the heart and gastrointestinal tract, which is why we focused on complications in these organs. Since the high transmissibility of Omicron and its ability to evade the immune system have raised worldwide concern, we have tried to summarise the current knowledge about its development from a structural point of view and to highlight the differences in its binding to human receptors and proteases compared to previous VOC. |
| first_indexed | 2024-03-08T21:30:51Z |
| format | Article |
| id | doaj.art-1eaa807940244e0c9cbc4dac7b5da62f |
| institution | Directory Open Access Journal |
| issn | 2001-0370 |
| language | English |
| last_indexed | 2024-03-08T21:30:51Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Computational and Structural Biotechnology Journal |
| spelling | doaj.art-1eaa807940244e0c9cbc4dac7b5da62f2023-12-21T07:30:49ZengElsevierComputational and Structural Biotechnology Journal2001-03702023-01-012110221029SARS-CoV-2 and its impact on the cardiovascular and digestive systems – The interplay between new virus variants and human cellsAngelika Szpulak0Urszula Garlak1Hanna Ćwirko2Bogusława Witkowska3Agnieszka Rombel-Bryzek4Danuta Witkowska5Faculty of Medicine, Wroclaw Medical University, Wybrzeże L. Pasteura 1, 50-367 Wrocław, PolandFaculty of Medicine, Wroclaw Medical University, Wybrzeże L. Pasteura 1, 50-367 Wrocław, PolandFaculty of Medicine, Wroclaw Medical University, Wybrzeże L. Pasteura 1, 50-367 Wrocław, PolandInstitute of Health Sciences, University of Opole, Katowicka 68, 45-060 Opole, PolandInstitute of Medical Sciences, University of Opole, Oleska 48, 45-052 Opole, PolandInstitute of Health Sciences, University of Opole, Katowicka 68, 45-060 Opole, Poland; Corresponding author.Since infection with the novel coronavirus SARS-CoV-2 first emerged in Wuhan, China, in December 2019, the world has been battling the pandemic COVID-19. Patients of all ages and genders are now becoming infected with the new coronavirus variant (Omicron) worldwide, and its subvariants continue to pose a threat to health and life. This article provides a literature review of cardiovascular and gastrointestinal complications resulting from SARS-CoV-2 infection. COVID-19 primarily caused respiratory symptoms, but complications can affect many vital organs. SARS-CoV-2 binds to a human cell receptor (angiotensin-converting enzyme 2 – ACE2) that is predominantly expressed primarily in the heart and gastrointestinal tract, which is why we focused on complications in these organs. Since the high transmissibility of Omicron and its ability to evade the immune system have raised worldwide concern, we have tried to summarise the current knowledge about its development from a structural point of view and to highlight the differences in its binding to human receptors and proteases compared to previous VOC.http://www.sciencedirect.com/science/article/pii/S2001037023000260SARS-CoV-2OmicronACE2 receptorMutationsCardiovascular and digestive systems |
| spellingShingle | Angelika Szpulak Urszula Garlak Hanna Ćwirko Bogusława Witkowska Agnieszka Rombel-Bryzek Danuta Witkowska SARS-CoV-2 and its impact on the cardiovascular and digestive systems – The interplay between new virus variants and human cells Computational and Structural Biotechnology Journal SARS-CoV-2 Omicron ACE2 receptor Mutations Cardiovascular and digestive systems |
| title | SARS-CoV-2 and its impact on the cardiovascular and digestive systems – The interplay between new virus variants and human cells |
| title_full | SARS-CoV-2 and its impact on the cardiovascular and digestive systems – The interplay between new virus variants and human cells |
| title_fullStr | SARS-CoV-2 and its impact on the cardiovascular and digestive systems – The interplay between new virus variants and human cells |
| title_full_unstemmed | SARS-CoV-2 and its impact on the cardiovascular and digestive systems – The interplay between new virus variants and human cells |
| title_short | SARS-CoV-2 and its impact on the cardiovascular and digestive systems – The interplay between new virus variants and human cells |
| title_sort | sars cov 2 and its impact on the cardiovascular and digestive systems the interplay between new virus variants and human cells |
| topic | SARS-CoV-2 Omicron ACE2 receptor Mutations Cardiovascular and digestive systems |
| url | http://www.sciencedirect.com/science/article/pii/S2001037023000260 |
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