Mitochondrial Dysfunction Plays Central Role in Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) is a global pandemic that affects one-quarter of the world’s population. NAFLD includes a spectrum of progressive liver disease from steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis and can be complicated by hepatocellular carcinoma....
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/13/7280 |
| _version_ | 1797479637182316544 |
|---|---|
| author | Raghu Ramanathan Ahmad Hassan Ali Jamal A. Ibdah |
| author_facet | Raghu Ramanathan Ahmad Hassan Ali Jamal A. Ibdah |
| author_sort | Raghu Ramanathan |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD) is a global pandemic that affects one-quarter of the world’s population. NAFLD includes a spectrum of progressive liver disease from steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis and can be complicated by hepatocellular carcinoma. It is strongly associated with metabolic syndromes, obesity, and type 2 diabetes, and it has been shown that metabolic dysregulation is central to its pathogenesis. Recently, it has been suggested that metabolic- (dysfunction) associated fatty liver disease (MAFLD) is a more appropriate term to describe the disease than NAFLD, which puts increased emphasis on the important role of metabolic dysfunction in its pathogenesis. There is strong evidence that mitochondrial dysfunction plays a significant role in the development and progression of NAFLD. Impaired mitochondrial fatty acid oxidation and, more recently, a reduction in mitochondrial quality, have been suggested to play a major role in NAFLD development and progression. In this review, we provide an overview of our current understanding of NAFLD and highlight how mitochondrial dysfunction contributes to its pathogenesis in both animal models and human subjects. Further we discuss evidence that the modification of mitochondrial function modulates NAFLD and that targeting mitochondria is a promising new avenue for drug development to treat NAFLD/NASH. |
| first_indexed | 2024-03-09T21:48:39Z |
| format | Article |
| id | doaj.art-1eacbb17422045d98d979cc800ee007a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:48:39Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1eacbb17422045d98d979cc800ee007a2023-11-23T20:11:05ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-06-012313728010.3390/ijms23137280Mitochondrial Dysfunction Plays Central Role in Nonalcoholic Fatty Liver DiseaseRaghu Ramanathan0Ahmad Hassan Ali1Jamal A. Ibdah2Division of Gastroenterology and Hepatology, University of Missouri, Columbia, MO 65212, USADivision of Gastroenterology and Hepatology, University of Missouri, Columbia, MO 65212, USADivision of Gastroenterology and Hepatology, University of Missouri, Columbia, MO 65212, USANonalcoholic fatty liver disease (NAFLD) is a global pandemic that affects one-quarter of the world’s population. NAFLD includes a spectrum of progressive liver disease from steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis and can be complicated by hepatocellular carcinoma. It is strongly associated with metabolic syndromes, obesity, and type 2 diabetes, and it has been shown that metabolic dysregulation is central to its pathogenesis. Recently, it has been suggested that metabolic- (dysfunction) associated fatty liver disease (MAFLD) is a more appropriate term to describe the disease than NAFLD, which puts increased emphasis on the important role of metabolic dysfunction in its pathogenesis. There is strong evidence that mitochondrial dysfunction plays a significant role in the development and progression of NAFLD. Impaired mitochondrial fatty acid oxidation and, more recently, a reduction in mitochondrial quality, have been suggested to play a major role in NAFLD development and progression. In this review, we provide an overview of our current understanding of NAFLD and highlight how mitochondrial dysfunction contributes to its pathogenesis in both animal models and human subjects. Further we discuss evidence that the modification of mitochondrial function modulates NAFLD and that targeting mitochondria is a promising new avenue for drug development to treat NAFLD/NASH.https://www.mdpi.com/1422-0067/23/13/7280livermitochondrial dysfunctionβ-oxidationnonalcoholic fatty liver diseasemitophagy |
| spellingShingle | Raghu Ramanathan Ahmad Hassan Ali Jamal A. Ibdah Mitochondrial Dysfunction Plays Central Role in Nonalcoholic Fatty Liver Disease International Journal of Molecular Sciences liver mitochondrial dysfunction β-oxidation nonalcoholic fatty liver disease mitophagy |
| title | Mitochondrial Dysfunction Plays Central Role in Nonalcoholic Fatty Liver Disease |
| title_full | Mitochondrial Dysfunction Plays Central Role in Nonalcoholic Fatty Liver Disease |
| title_fullStr | Mitochondrial Dysfunction Plays Central Role in Nonalcoholic Fatty Liver Disease |
| title_full_unstemmed | Mitochondrial Dysfunction Plays Central Role in Nonalcoholic Fatty Liver Disease |
| title_short | Mitochondrial Dysfunction Plays Central Role in Nonalcoholic Fatty Liver Disease |
| title_sort | mitochondrial dysfunction plays central role in nonalcoholic fatty liver disease |
| topic | liver mitochondrial dysfunction β-oxidation nonalcoholic fatty liver disease mitophagy |
| url | https://www.mdpi.com/1422-0067/23/13/7280 |
| work_keys_str_mv | AT raghuramanathan mitochondrialdysfunctionplayscentralroleinnonalcoholicfattyliverdisease AT ahmadhassanali mitochondrialdysfunctionplayscentralroleinnonalcoholicfattyliverdisease AT jamalaibdah mitochondrialdysfunctionplayscentralroleinnonalcoholicfattyliverdisease |