Synthesis, characterization and antitumor activity of the germanium-quercetin complex
Quercetin-germanium (Ge) (IV) complex was synthesized in the laboratory. The structure and physicochemical properties of the complex were characterized utilizing thermal and spectroscopic (UV-vis, IR and 1H NMR) analysis. The antitumor activity of quercetin-Ge (IV) compound was evaluated by the MTT...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2012-09-01
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| Series: | Main Group Metal Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/mgmc-2012-0026 |
| _version_ | 1818676703317196800 |
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| author | Zhai Guangyu Zhu Wei Duan Yandan Qu Wentao Yan Zitong |
| author_facet | Zhai Guangyu Zhu Wei Duan Yandan Qu Wentao Yan Zitong |
| author_sort | Zhai Guangyu |
| collection | DOAJ |
| description | Quercetin-germanium (Ge) (IV) complex was synthesized in the laboratory. The structure and physicochemical properties of the complex were characterized utilizing thermal and spectroscopic (UV-vis, IR and 1H NMR) analysis. The antitumor activity of quercetin-Ge (IV) compound was evaluated by the MTT method. The complex was subjected to biological tests in vitro using four tumor cell lines (PC-3, Hela, EC9706 and SPC-A-1). The quercetin-Ge (IV) complex showed significant cytotoxicity against four tumor cell lines. |
| first_indexed | 2024-12-17T08:47:41Z |
| format | Article |
| id | doaj.art-1ead186dfb554baaa8d4fcf90917df52 |
| institution | Directory Open Access Journal |
| issn | 0792-1241 2191-0219 |
| language | English |
| last_indexed | 2024-12-17T08:47:41Z |
| publishDate | 2012-09-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Main Group Metal Chemistry |
| spelling | doaj.art-1ead186dfb554baaa8d4fcf90917df522022-12-21T21:56:10ZengDe GruyterMain Group Metal Chemistry0792-12412191-02192012-09-01353-410310910.1515/mgmc-2012-0026Synthesis, characterization and antitumor activity of the germanium-quercetin complexZhai Guangyu0Zhu Wei1Duan Yandan2Qu Wentao3Yan Zitong4College of Nursing, Zhengzhou University, 450052 Zhengzhou, ChinaCollege of Pharmaceutical Sciences, Zhengzhou University, 450001 Zhengzhou, ChinaCollege of Nursing, Zhengzhou University, 450052 Zhengzhou, ChinaCollege of Pharmaceutical Sciences, Zhengzhou University, 450001 Zhengzhou, ChinaCollege of Pharmaceutical Sciences, Zhengzhou University, 450001 Zhengzhou, ChinaQuercetin-germanium (Ge) (IV) complex was synthesized in the laboratory. The structure and physicochemical properties of the complex were characterized utilizing thermal and spectroscopic (UV-vis, IR and 1H NMR) analysis. The antitumor activity of quercetin-Ge (IV) compound was evaluated by the MTT method. The complex was subjected to biological tests in vitro using four tumor cell lines (PC-3, Hela, EC9706 and SPC-A-1). The quercetin-Ge (IV) complex showed significant cytotoxicity against four tumor cell lines.https://doi.org/10.1515/mgmc-2012-0026antitumorflavonoidsquercetin-germanium (ge) (iv) complexationspectroscopy |
| spellingShingle | Zhai Guangyu Zhu Wei Duan Yandan Qu Wentao Yan Zitong Synthesis, characterization and antitumor activity of the germanium-quercetin complex Main Group Metal Chemistry antitumor flavonoids quercetin-germanium (ge) (iv) complexation spectroscopy |
| title | Synthesis, characterization and antitumor activity of the germanium-quercetin complex |
| title_full | Synthesis, characterization and antitumor activity of the germanium-quercetin complex |
| title_fullStr | Synthesis, characterization and antitumor activity of the germanium-quercetin complex |
| title_full_unstemmed | Synthesis, characterization and antitumor activity of the germanium-quercetin complex |
| title_short | Synthesis, characterization and antitumor activity of the germanium-quercetin complex |
| title_sort | synthesis characterization and antitumor activity of the germanium quercetin complex |
| topic | antitumor flavonoids quercetin-germanium (ge) (iv) complexation spectroscopy |
| url | https://doi.org/10.1515/mgmc-2012-0026 |
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