Merging rhodium-catalysed C–H activation and hydroamination in a highly selective [4+2] imine/alkyne annulation
C–H activations and hydroaminations are useful synthetic procedures for building up complex, functional molecules. Here, the authors report a single catalyst capable of performing tandem C–H activation and hydroamination, giving access to N-heterocycles via the [4+2] annulation of aromatic imines an...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2016-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11506 |
| _version_ | 1819035754492329984 |
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| author | Rajith S. Manan Pinjing Zhao |
| author_facet | Rajith S. Manan Pinjing Zhao |
| author_sort | Rajith S. Manan |
| collection | DOAJ |
| description | C–H activations and hydroaminations are useful synthetic procedures for building up complex, functional molecules. Here, the authors report a single catalyst capable of performing tandem C–H activation and hydroamination, giving access to N-heterocycles via the [4+2] annulation of aromatic imines and alkynes. |
| first_indexed | 2024-12-21T07:54:39Z |
| format | Article |
| id | doaj.art-1eadc2309b74490a95a6d8f34cbf5eb0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-21T07:54:39Z |
| publishDate | 2016-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-1eadc2309b74490a95a6d8f34cbf5eb02022-12-21T19:11:00ZengNature PortfolioNature Communications2041-17232016-06-017111110.1038/ncomms11506Merging rhodium-catalysed C–H activation and hydroamination in a highly selective [4+2] imine/alkyne annulationRajith S. Manan0Pinjing Zhao1Department of Chemistry and Biochemistry, North Dakota State UniversityDepartment of Chemistry and Biochemistry, North Dakota State UniversityC–H activations and hydroaminations are useful synthetic procedures for building up complex, functional molecules. Here, the authors report a single catalyst capable of performing tandem C–H activation and hydroamination, giving access to N-heterocycles via the [4+2] annulation of aromatic imines and alkynes.https://doi.org/10.1038/ncomms11506 |
| spellingShingle | Rajith S. Manan Pinjing Zhao Merging rhodium-catalysed C–H activation and hydroamination in a highly selective [4+2] imine/alkyne annulation Nature Communications |
| title | Merging rhodium-catalysed C–H activation and hydroamination in a highly selective [4+2] imine/alkyne annulation |
| title_full | Merging rhodium-catalysed C–H activation and hydroamination in a highly selective [4+2] imine/alkyne annulation |
| title_fullStr | Merging rhodium-catalysed C–H activation and hydroamination in a highly selective [4+2] imine/alkyne annulation |
| title_full_unstemmed | Merging rhodium-catalysed C–H activation and hydroamination in a highly selective [4+2] imine/alkyne annulation |
| title_short | Merging rhodium-catalysed C–H activation and hydroamination in a highly selective [4+2] imine/alkyne annulation |
| title_sort | merging rhodium catalysed c h activation and hydroamination in a highly selective 4 2 imine alkyne annulation |
| url | https://doi.org/10.1038/ncomms11506 |
| work_keys_str_mv | AT rajithsmanan mergingrhodiumcatalysedchactivationandhydroaminationinahighlyselective42iminealkyneannulation AT pinjingzhao mergingrhodiumcatalysedchactivationandhydroaminationinahighlyselective42iminealkyneannulation |