Differential dynamics of bone graft transplantation and mesenchymal stem cell therapy during bone defect healing in a murine critical size defect

Differential dynamics of bone graft transplantation and mesenchymal stem cell therapy during bone defect healing in a murine critical size defect

Background: A critical size bone defect is a clinical scenario in which bone is lost or excised due to trauma, infection, tumor, or other causes, and cannot completely heal spontaneously. The most common treatment for this condition is autologous bone grafting to the defect site. However, autologous...

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Bibliographic Details
Main Authors: Elijah Ejun Huang, Ning Zhang, Edward A. Ganio, Huaishuang Shen, Xueping Li, Masaya Ueno, Takeshi Utsunomiya, Masahiro Maruyama, Qi Gao, Ni Su, Zhenyu Yao, Fan Yang, Brice Gaudillière, Stuart B. Goodman
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Journal of Orthopaedic Translation
Subjects:
Bone graft
Critical-size bone defect
CyTOF
Macrophages
Stem cells
T cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X2200047X

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