A Simple UPLC/MS-MS Method for Simultaneous Determination of Lenvatinib and Telmisartan in Rat Plasma, and Its Application to Pharmacokinetic Drug-Drug Interaction Study

A Simple UPLC/MS-MS Method for Simultaneous Determination of Lenvatinib and Telmisartan in Rat Plasma, and Its Application to Pharmacokinetic Drug-Drug Interaction Study

Lenvatinib is a multi-targeted tyrosine kinase inhibitor that inhibits tumor angiogenesis, but hypertension is the most common adverse reaction. Telmisartan is an angiotensin receptor blocker used to treat hypertension. In this study, a simple ultra-performance liquid chromatography-tandem mass spec...

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Bibliographic Details
Main Authors:	Yanjun Cui, Ying Li, Xiao Li, Liju Fan, Xueru He, Yuhao Fu, Zhanjun Dong
Format:	Article
Language:	English
Published:	MDPI AG 2022-02-01
Series:	Molecules
Subjects:	UPLC-MS/MS lenvatinib telmisartan pharmacokinetics drug-drug interaction
Online Access:	https://www.mdpi.com/1420-3049/27/4/1291

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