Laparoscopic or Open Adrenalectomy for Stage I–II Adrenocortical Carcinoma: A Retrospective Study
Surgical resection of adrenocortical carcinoma (ACC) is the only curative treatment. Even in localized (I–II) stages, open adrenalectomy (OA) is the gold standard, though laparoscopic adrenalectomy (LA) can be proposed in selected patients. Despite the postoperative benefits of LA, its role in the s...
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MDPI AG
2023-05-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/11/3698 |
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| author | Martin Gaillard Meva Razafinimanana Alexandre Challine Raphael L. C. Araujo Rossella Libé Mathilde Sibony Maxime Barat Jérôme Bertherat Bertrand Dousset David Fuks Sebastien Gaujoux |
| author_facet | Martin Gaillard Meva Razafinimanana Alexandre Challine Raphael L. C. Araujo Rossella Libé Mathilde Sibony Maxime Barat Jérôme Bertherat Bertrand Dousset David Fuks Sebastien Gaujoux |
| author_sort | Martin Gaillard |
| collection | DOAJ |
| description | Surgical resection of adrenocortical carcinoma (ACC) is the only curative treatment. Even in localized (I–II) stages, open adrenalectomy (OA) is the gold standard, though laparoscopic adrenalectomy (LA) can be proposed in selected patients. Despite the postoperative benefits of LA, its role in the surgical management of patients with ACC remains controversial regarding oncologic outcomes. The aim of this retrospective study was to compare the outcomes of patients with localized ACC submitted to LA or OA in a referral center from 1995 to 2020. Among 180 consecutive patients operated on for ACC, 49 presented with localized ACC (19 LA and 30 OA). Baseline characteristics were similar between groups, except for tumor size. Kaplan-Meier estimates of 5-year overall survival were similar in both groups (<i>p</i> = 0.166) but 3-year disease-free survival was in favor of OA (<i>p</i> = 0.020). Though LA could be proposed in highly selected patients, OA should still be considered the standard approach in patients with known or suspected localized ACC. |
| first_indexed | 2024-03-11T03:03:17Z |
| format | Article |
| id | doaj.art-1eb56391eb414f6dabeac5bb8bc5fbb2 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T03:03:17Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-1eb56391eb414f6dabeac5bb8bc5fbb22023-11-18T08:05:11ZengMDPI AGJournal of Clinical Medicine2077-03832023-05-011211369810.3390/jcm12113698Laparoscopic or Open Adrenalectomy for Stage I–II Adrenocortical Carcinoma: A Retrospective StudyMartin Gaillard0Meva Razafinimanana1Alexandre Challine2Raphael L. C. Araujo3Rossella Libé4Mathilde Sibony5Maxime Barat6Jérôme Bertherat7Bertrand Dousset8David Fuks9Sebastien Gaujoux10Department of Digestive, Hepatobiliary and Endocrine Surgery, Hôpital Cochin, APHP.Centre, 75014 Paris, FranceDepartment of Digestive, Hepatobiliary and Endocrine Surgery, Hôpital Cochin, APHP.Centre, 75014 Paris, FranceDepartment of Digestive Surgery, Hôpital Saint-Antoine, APHP.Sorbonne Université, 75012 Paris, FranceDepartment of Surgery, Hospital Israelita Albert Einstein, Universidade Federal de Sao Paulo, Sao Paulo 05652-900, BrazilDepartment of Endocrinology, Hôpital Cochin, APHP.Centre, 75014 Paris, FranceDepartment of Pathology, Hôpital Cochin, APHP.Centre, 75014 Paris, FranceDepartment of Radiology, Hôpital Cochin, APHP.Centre, 75014 Paris, FranceDepartment of Endocrinology, Hôpital Cochin, APHP.Centre, 75014 Paris, FranceDepartment of Digestive, Hepatobiliary and Endocrine Surgery, Hôpital Cochin, APHP.Centre, 75014 Paris, FranceDepartment of Digestive, Hepatobiliary and Endocrine Surgery, Hôpital Cochin, APHP.Centre, 75014 Paris, FranceDepartment of Hepato-Biliary and Pancreatic Surgery and Liver Transplantation, Hôpital Pitié-Salpêtrière, APHP.Sorbonne Université, 75013 Paris, FranceSurgical resection of adrenocortical carcinoma (ACC) is the only curative treatment. Even in localized (I–II) stages, open adrenalectomy (OA) is the gold standard, though laparoscopic adrenalectomy (LA) can be proposed in selected patients. Despite the postoperative benefits of LA, its role in the surgical management of patients with ACC remains controversial regarding oncologic outcomes. The aim of this retrospective study was to compare the outcomes of patients with localized ACC submitted to LA or OA in a referral center from 1995 to 2020. Among 180 consecutive patients operated on for ACC, 49 presented with localized ACC (19 LA and 30 OA). Baseline characteristics were similar between groups, except for tumor size. Kaplan-Meier estimates of 5-year overall survival were similar in both groups (<i>p</i> = 0.166) but 3-year disease-free survival was in favor of OA (<i>p</i> = 0.020). Though LA could be proposed in highly selected patients, OA should still be considered the standard approach in patients with known or suspected localized ACC.https://www.mdpi.com/2077-0383/12/11/3698adrenocortical carcinomaadrenalectomylaparoscopy |
| spellingShingle | Martin Gaillard Meva Razafinimanana Alexandre Challine Raphael L. C. Araujo Rossella Libé Mathilde Sibony Maxime Barat Jérôme Bertherat Bertrand Dousset David Fuks Sebastien Gaujoux Laparoscopic or Open Adrenalectomy for Stage I–II Adrenocortical Carcinoma: A Retrospective Study Journal of Clinical Medicine adrenocortical carcinoma adrenalectomy laparoscopy |
| title | Laparoscopic or Open Adrenalectomy for Stage I–II Adrenocortical Carcinoma: A Retrospective Study |
| title_full | Laparoscopic or Open Adrenalectomy for Stage I–II Adrenocortical Carcinoma: A Retrospective Study |
| title_fullStr | Laparoscopic or Open Adrenalectomy for Stage I–II Adrenocortical Carcinoma: A Retrospective Study |
| title_full_unstemmed | Laparoscopic or Open Adrenalectomy for Stage I–II Adrenocortical Carcinoma: A Retrospective Study |
| title_short | Laparoscopic or Open Adrenalectomy for Stage I–II Adrenocortical Carcinoma: A Retrospective Study |
| title_sort | laparoscopic or open adrenalectomy for stage i ii adrenocortical carcinoma a retrospective study |
| topic | adrenocortical carcinoma adrenalectomy laparoscopy |
| url | https://www.mdpi.com/2077-0383/12/11/3698 |
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