Characteristics of epidemiological and molecular relationships between allergic diseases and helminth disorders in Opisthorchis endemic region
To elucidate the molecular mechanisms of O. felineus impact into phenotypic variability of allergic diseases in the opisthorchis endemic region, we studied 104 patients with opisthorchosis, 92 patients with atopic bronchial asthma, 52 patients with a combination of both diseases, and 120 healthy per...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Siberian State Medical University (Tomsk)
2008-12-01
|
| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/3530 |
| _version_ | 1797873219601956864 |
|---|---|
| author | L. M. Ogorodova O. S. Fyodorova M. B. Freidin M. B. Vasil’yeva N. A. Cherevko A. E. Sazonov I. V. Petrova I. V. Saltykova Ye. Yu. Bragina Ye. S. Kulikov I. A. Deyev |
| author_facet | L. M. Ogorodova O. S. Fyodorova M. B. Freidin M. B. Vasil’yeva N. A. Cherevko A. E. Sazonov I. V. Petrova I. V. Saltykova Ye. Yu. Bragina Ye. S. Kulikov I. A. Deyev |
| author_sort | L. M. Ogorodova |
| collection | DOAJ |
| description | To elucidate the molecular mechanisms of O. felineus impact into phenotypic variability of allergic diseases in the opisthorchis endemic region, we studied 104 patients with opisthorchosis, 92 patients with atopic bronchial asthma, 52 patients with a combination of both diseases, and 120 healthy persons. Standard clinical, immunological, and genetic methods were used. An association of opisthorchis invasion with the improvement of lung function signs and bronchial hyperreactivity was found. It was established, that IL-4-dependent mechanisms of atopy were suppressed by O. felineus antigens, in particular due to hyperproduction of IL-10 and transforming growth factor-beta. However, IL-5-dependant mechanisms were supported. A phenomenology of the cytokine gene differential expression was established, disclosing the molecular basis of the immune system function in diseases with polar immune response in the helminth endemic region. |
| first_indexed | 2024-04-10T01:11:37Z |
| format | Article |
| id | doaj.art-1eb7a3e2a725493882f84369fbfa3eed |
| institution | Directory Open Access Journal |
| issn | 1682-0363 1819-3684 |
| language | English |
| last_indexed | 2024-04-10T01:11:37Z |
| publishDate | 2008-12-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj.art-1eb7a3e2a725493882f84369fbfa3eed2023-03-13T09:58:09ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842008-12-0174374410.20538/1682-0363-2008-4-37-442174Characteristics of epidemiological and molecular relationships between allergic diseases and helminth disorders in Opisthorchis endemic regionL. M. Ogorodova0O. S. Fyodorova1M. B. Freidin2M. B. Vasil’yeva3N. A. Cherevko4A. E. Sazonov5I. V. Petrova6I. V. Saltykova7Ye. Yu. Bragina8Ye. S. Kulikov9I. A. Deyev10Сибирский государственный медицинский университетСибирский государственный медицинский университетНИИ медицинской генетики ТНЦ СО РАМНСибирский государственный медицинский университетСибирский государственный медицинский университетСибирский государственный медицинский университетСибирский государственный медицинский университетСибирский государственный медицинский университетНИИ медицинской генетики ТНЦ СО РАМНСибирский государственный медицинский университетСибирский государственный медицинский университетTo elucidate the molecular mechanisms of O. felineus impact into phenotypic variability of allergic diseases in the opisthorchis endemic region, we studied 104 patients with opisthorchosis, 92 patients with atopic bronchial asthma, 52 patients with a combination of both diseases, and 120 healthy persons. Standard clinical, immunological, and genetic methods were used. An association of opisthorchis invasion with the improvement of lung function signs and bronchial hyperreactivity was found. It was established, that IL-4-dependent mechanisms of atopy were suppressed by O. felineus antigens, in particular due to hyperproduction of IL-10 and transforming growth factor-beta. However, IL-5-dependant mechanisms were supported. A phenomenology of the cytokine gene differential expression was established, disclosing the molecular basis of the immune system function in diseases with polar immune response in the helminth endemic region.https://bulletin.ssmu.ru/jour/article/view/3530атопические болезниастмаописторхозэпидемиологиярегуляция иммунного ответа |
| spellingShingle | L. M. Ogorodova O. S. Fyodorova M. B. Freidin M. B. Vasil’yeva N. A. Cherevko A. E. Sazonov I. V. Petrova I. V. Saltykova Ye. Yu. Bragina Ye. S. Kulikov I. A. Deyev Characteristics of epidemiological and molecular relationships between allergic diseases and helminth disorders in Opisthorchis endemic region Бюллетень сибирской медицины атопические болезни астма описторхоз эпидемиология регуляция иммунного ответа |
| title | Characteristics of epidemiological and molecular relationships between allergic diseases and helminth disorders in Opisthorchis endemic region |
| title_full | Characteristics of epidemiological and molecular relationships between allergic diseases and helminth disorders in Opisthorchis endemic region |
| title_fullStr | Characteristics of epidemiological and molecular relationships between allergic diseases and helminth disorders in Opisthorchis endemic region |
| title_full_unstemmed | Characteristics of epidemiological and molecular relationships between allergic diseases and helminth disorders in Opisthorchis endemic region |
| title_short | Characteristics of epidemiological and molecular relationships between allergic diseases and helminth disorders in Opisthorchis endemic region |
| title_sort | characteristics of epidemiological and molecular relationships between allergic diseases and helminth disorders in opisthorchis endemic region |
| topic | атопические болезни астма описторхоз эпидемиология регуляция иммунного ответа |
| url | https://bulletin.ssmu.ru/jour/article/view/3530 |
| work_keys_str_mv | AT lmogorodova characteristicsofepidemiologicalandmolecularrelationshipsbetweenallergicdiseasesandhelminthdisordersinopisthorchisendemicregion AT osfyodorova characteristicsofepidemiologicalandmolecularrelationshipsbetweenallergicdiseasesandhelminthdisordersinopisthorchisendemicregion AT mbfreidin characteristicsofepidemiologicalandmolecularrelationshipsbetweenallergicdiseasesandhelminthdisordersinopisthorchisendemicregion AT mbvasilyeva characteristicsofepidemiologicalandmolecularrelationshipsbetweenallergicdiseasesandhelminthdisordersinopisthorchisendemicregion AT nacherevko characteristicsofepidemiologicalandmolecularrelationshipsbetweenallergicdiseasesandhelminthdisordersinopisthorchisendemicregion AT aesazonov characteristicsofepidemiologicalandmolecularrelationshipsbetweenallergicdiseasesandhelminthdisordersinopisthorchisendemicregion AT ivpetrova characteristicsofepidemiologicalandmolecularrelationshipsbetweenallergicdiseasesandhelminthdisordersinopisthorchisendemicregion AT ivsaltykova characteristicsofepidemiologicalandmolecularrelationshipsbetweenallergicdiseasesandhelminthdisordersinopisthorchisendemicregion AT yeyubragina characteristicsofepidemiologicalandmolecularrelationshipsbetweenallergicdiseasesandhelminthdisordersinopisthorchisendemicregion AT yeskulikov characteristicsofepidemiologicalandmolecularrelationshipsbetweenallergicdiseasesandhelminthdisordersinopisthorchisendemicregion AT iadeyev characteristicsofepidemiologicalandmolecularrelationshipsbetweenallergicdiseasesandhelminthdisordersinopisthorchisendemicregion |