Heterogeneity in allospecific T cell function in transplant-tolerant hosts determines susceptibility to rejection following infection

Heterogeneity in allospecific T cell function in transplant-tolerant hosts determines susceptibility to rejection following infection

Even when successfully induced, immunological tolerance to solid organs remains vulnerable to inflammatory insults, which can trigger rejection. In a mouse model of cardiac allograft tolerance in which infection with Listeria monocytogenes (Lm) precipitates rejection of previously accepted grafts, w...

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Bibliographic Details
Main Authors: Christine M. McIntosh, Jennifer B. Allocco, Peter Wang, Michelle L. McKeague, Alexandra Cassano, Ying Wang, Stephen Z. Xie, Grace Hynes, Ricardo Mora-Cartín, Domenic Abbondanza, Luqiu Chen, Husain Sattar, Dengping Yin, Zheng J. Zhang, Anita S. Chong, Maria-Luisa Alegre
Format: Article
Language:English
Published: American Society for Clinical Investigation 2023-11-01
Series:The Journal of Clinical Investigation
Subjects:
Transplantation
Online Access:https://doi.org/10.1172/JCI168465

Internet

https://doi.org/10.1172/JCI168465

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