The Role of Osteopontin in Psoriasis—A Scoping Review
Psoriasis is a chronic systemic disease with an immunological basis and a complex pathophysiology. The chronic inflammatory status of psoriasis is associated with several comorbidities, such as metabolic syndrome, obesity, and cardiovascular disease. The development of psoriasis is influenced by ost...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/3/655 |
| _version_ | 1797318577336877056 |
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| author | Agnieszka Kimak Anna Woźniacka |
| author_facet | Agnieszka Kimak Anna Woźniacka |
| author_sort | Agnieszka Kimak |
| collection | DOAJ |
| description | Psoriasis is a chronic systemic disease with an immunological basis and a complex pathophysiology. The chronic inflammatory status of psoriasis is associated with several comorbidities, such as metabolic syndrome, obesity, and cardiovascular disease. The development of psoriasis is influenced by osteopontin, a glycoprotein that influences physiological and pathological reactions by modulating Th1 and Th17 cellular responses, stimulating keratinocyte proliferation, regulating cellular apoptosis, and promoting angiogenesis. The recent identification of immune pathways involved in psoriasis development has facilitated the development of biological treatments; however, a better understanding of the intricate relationship between underlying inflammatory processes, psoriasis development, and accompanying comorbidities is needed for improved disease management. |
| first_indexed | 2024-03-08T03:54:21Z |
| format | Article |
| id | doaj.art-1eb9b3a24d5745779a885b5cd8e34df2 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-08T03:54:21Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-1eb9b3a24d5745779a885b5cd8e34df22024-02-09T15:15:27ZengMDPI AGJournal of Clinical Medicine2077-03832024-01-0113365510.3390/jcm13030655The Role of Osteopontin in Psoriasis—A Scoping ReviewAgnieszka Kimak0Anna Woźniacka1Department of Dermatology and Venereology, Medical University of Lodz, Hallera 1, 90-647 Lodz, PolandDepartment of Dermatology and Venereology, Medical University of Lodz, Hallera 1, 90-647 Lodz, PolandPsoriasis is a chronic systemic disease with an immunological basis and a complex pathophysiology. The chronic inflammatory status of psoriasis is associated with several comorbidities, such as metabolic syndrome, obesity, and cardiovascular disease. The development of psoriasis is influenced by osteopontin, a glycoprotein that influences physiological and pathological reactions by modulating Th1 and Th17 cellular responses, stimulating keratinocyte proliferation, regulating cellular apoptosis, and promoting angiogenesis. The recent identification of immune pathways involved in psoriasis development has facilitated the development of biological treatments; however, a better understanding of the intricate relationship between underlying inflammatory processes, psoriasis development, and accompanying comorbidities is needed for improved disease management.https://www.mdpi.com/2077-0383/13/3/655comorbiditiesosteopontinpsoriasis |
| spellingShingle | Agnieszka Kimak Anna Woźniacka The Role of Osteopontin in Psoriasis—A Scoping Review Journal of Clinical Medicine comorbidities osteopontin psoriasis |
| title | The Role of Osteopontin in Psoriasis—A Scoping Review |
| title_full | The Role of Osteopontin in Psoriasis—A Scoping Review |
| title_fullStr | The Role of Osteopontin in Psoriasis—A Scoping Review |
| title_full_unstemmed | The Role of Osteopontin in Psoriasis—A Scoping Review |
| title_short | The Role of Osteopontin in Psoriasis—A Scoping Review |
| title_sort | role of osteopontin in psoriasis a scoping review |
| topic | comorbidities osteopontin psoriasis |
| url | https://www.mdpi.com/2077-0383/13/3/655 |
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