What factors affect the effectiveness of long - term analgesic therapy for osteoarthritis? Data analysis of the multi - center 3-month PARACELSUS study
There are factors that can affect the effectiveness of treatment of osteoarthritis (OA). Aim to identify factors affecting the effectiveness of long - term analgesic therapy in OA. Materials and methods. The study included 6448 patients (70.9% female and 29.1% male), middle age 57.8±10.2 years, with...
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2019-05-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/33613/pdf |
| _version_ | 1830492094030938112 |
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| author | A E Karateev A M Lila E Yu Pogozheva V N Amirdzhanova E S Filatova |
| author_facet | A E Karateev A M Lila E Yu Pogozheva V N Amirdzhanova E S Filatova |
| author_sort | A E Karateev |
| collection | DOAJ |
| description | There are factors that can affect the effectiveness of treatment of osteoarthritis (OA). Aim to identify factors affecting the effectiveness of long - term analgesic therapy in OA. Materials and methods. The study included 6448 patients (70.9% female and 29.1% male), middle age 57.8±10.2 years, with severe pain [≥40 mm on the visual analog scale]. All patients received the preparation of avocado - soybean unsaponifiables (ASU) 300 mg/day. For pain relief at the beginning and during the study, the drug Ketoprofen lysine salt (KLS) 320 mg/day was used. The efficiency criterion was pain reduction ≥50% and satisfaction with treatment ≥4 on a 5-point scale. The influence of a number of factors on the result of treatment was evaluated. Results. For 3 months of treatment, the pain decreased from 63.7±12.0 to 14.2±11.7 mm VAS. The result was evaluated as "good" or "excellent" 81.7% of patients. Adverse reactions were rare. In total, a good response to therapy was noted in 87.4% of patients. Gender, body mass index ≥30 kg/m2, type 2 diabetes mellitus, poor effect of non - steroidal anti - inflammatory drugs (NSAIDs) and Symptomatic Slow-Acting Drugs in Osteoarthritis (SYSADOA) in history did not affect the result. The effect was lower in persons >65 years [odds ratio (OR) 0.418; 95% confidence interval (CI) 0.342-0.509, p2 by Kellgren-Lawrence (OR 0.556; 95% CI 0.298-0.738, p |
| first_indexed | 2024-12-21T20:23:51Z |
| format | Article |
| id | doaj.art-1ebce5ed97424e3b86b76b7f56fc6ada |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-21T20:23:51Z |
| publishDate | 2019-05-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-1ebce5ed97424e3b86b76b7f56fc6ada2022-12-21T18:51:26Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422019-05-01915687510.26442/00403660.2019.05.00023330342What factors affect the effectiveness of long - term analgesic therapy for osteoarthritis? Data analysis of the multi - center 3-month PARACELSUS studyA E Karateev0A M Lila1E Yu Pogozheva2V N Amirdzhanova3E S Filatova4V.A. Nasonova Scientific and Research Institute of RheumatologyV.A. Nasonova Scientific and Research Institute of RheumatologyV.A. Nasonova Scientific and Research Institute of RheumatologyV.A. Nasonova Scientific and Research Institute of RheumatologyV.A. Nasonova Scientific and Research Institute of RheumatologyThere are factors that can affect the effectiveness of treatment of osteoarthritis (OA). Aim to identify factors affecting the effectiveness of long - term analgesic therapy in OA. Materials and methods. The study included 6448 patients (70.9% female and 29.1% male), middle age 57.8±10.2 years, with severe pain [≥40 mm on the visual analog scale]. All patients received the preparation of avocado - soybean unsaponifiables (ASU) 300 mg/day. For pain relief at the beginning and during the study, the drug Ketoprofen lysine salt (KLS) 320 mg/day was used. The efficiency criterion was pain reduction ≥50% and satisfaction with treatment ≥4 on a 5-point scale. The influence of a number of factors on the result of treatment was evaluated. Results. For 3 months of treatment, the pain decreased from 63.7±12.0 to 14.2±11.7 mm VAS. The result was evaluated as "good" or "excellent" 81.7% of patients. Adverse reactions were rare. In total, a good response to therapy was noted in 87.4% of patients. Gender, body mass index ≥30 kg/m2, type 2 diabetes mellitus, poor effect of non - steroidal anti - inflammatory drugs (NSAIDs) and Symptomatic Slow-Acting Drugs in Osteoarthritis (SYSADOA) in history did not affect the result. The effect was lower in persons >65 years [odds ratio (OR) 0.418; 95% confidence interval (CI) 0.342-0.509, p2 by Kellgren-Lawrence (OR 0.556; 95% CI 0.298-0.738, phttps://ter-arkhiv.ru/0040-3660/article/viewFile/33613/pdfosteoarthritistreatmentsysadoaavocado-soybean unsaponifiablesnonsteroidal anti-inflammatory drugsketoprofen lysine salt |
| spellingShingle | A E Karateev A M Lila E Yu Pogozheva V N Amirdzhanova E S Filatova What factors affect the effectiveness of long - term analgesic therapy for osteoarthritis? Data analysis of the multi - center 3-month PARACELSUS study Терапевтический архив osteoarthritis treatment sysadoa avocado-soybean unsaponifiables nonsteroidal anti-inflammatory drugs ketoprofen lysine salt |
| title | What factors affect the effectiveness of long - term analgesic therapy for osteoarthritis? Data analysis of the multi - center 3-month PARACELSUS study |
| title_full | What factors affect the effectiveness of long - term analgesic therapy for osteoarthritis? Data analysis of the multi - center 3-month PARACELSUS study |
| title_fullStr | What factors affect the effectiveness of long - term analgesic therapy for osteoarthritis? Data analysis of the multi - center 3-month PARACELSUS study |
| title_full_unstemmed | What factors affect the effectiveness of long - term analgesic therapy for osteoarthritis? Data analysis of the multi - center 3-month PARACELSUS study |
| title_short | What factors affect the effectiveness of long - term analgesic therapy for osteoarthritis? Data analysis of the multi - center 3-month PARACELSUS study |
| title_sort | what factors affect the effectiveness of long term analgesic therapy for osteoarthritis data analysis of the multi center 3 month paracelsus study |
| topic | osteoarthritis treatment sysadoa avocado-soybean unsaponifiables nonsteroidal anti-inflammatory drugs ketoprofen lysine salt |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/33613/pdf |
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