Salmonella Interacts With Autophagy to Offense or Defense

Autophagy is an important component of the innate immune system in mammals. Low levels of basic autophagy are sustained in normal cells, to help with the clearance of aging organelles and misfolded proteins, thus maintaining their structural and functional stability. However, when cells are faced wi...

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Main Authors: Shu Wu, Yiru Shen, Shan Zhang, Yunqi Xiao, Shourong Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Microbiology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.00721/full
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author Shu Wu
Shu Wu
Shu Wu
Yiru Shen
Yiru Shen
Shan Zhang
Shan Zhang
Yunqi Xiao
Yunqi Xiao
Shourong Shi
Shourong Shi
Shourong Shi
author_facet Shu Wu
Shu Wu
Shu Wu
Yiru Shen
Yiru Shen
Shan Zhang
Shan Zhang
Yunqi Xiao
Yunqi Xiao
Shourong Shi
Shourong Shi
Shourong Shi
author_sort Shu Wu
collection DOAJ
description Autophagy is an important component of the innate immune system in mammals. Low levels of basic autophagy are sustained in normal cells, to help with the clearance of aging organelles and misfolded proteins, thus maintaining their structural and functional stability. However, when cells are faced with challenges, such as starvation or pathogenic infection, their level of autophagy increases significantly. Salmonella is a facultative intracellular pathogen, which imposes an economic burden on the poultry farming industry and human public health. Previous studies have shown that Salmonella can induce the autophagy of cells following invasion, which to a certain extent helps to protect the cells from bacterial colonization. This review summarizes the latest research in the field of Salmonella-induced autophagy, including: (i) the autophagy induction and escape mechanisms employed by Salmonella during the infection of host cells; (ii) the effect of autophagy on intracellular Salmonella; (iii) the important autophagy adaptors that recognize intracellular Salmonella in host cells; and (iv) the effect of autophagy-modulating drugs on Salmonella infection.
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spelling doaj.art-1ebec871fad64f09a05e6cf64a9fa72a2022-12-21T17:45:30ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2020-04-011110.3389/fmicb.2020.00721515222Salmonella Interacts With Autophagy to Offense or DefenseShu Wu0Shu Wu1Shu Wu2Yiru Shen3Yiru Shen4Shan Zhang5Shan Zhang6Yunqi Xiao7Yunqi Xiao8Shourong Shi9Shourong Shi10Shourong Shi11Department of Feed and Nutrition, Poultry Institute, Chinese Academy of Agricultural Sciences, Yangzhou, ChinaInstitute of Effective Evaluation of Feed and Feed Additive (Poultry institute), Ministry of Agriculture, Yangzhou, ChinaCollege of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaDepartment of Feed and Nutrition, Poultry Institute, Chinese Academy of Agricultural Sciences, Yangzhou, ChinaInstitute of Effective Evaluation of Feed and Feed Additive (Poultry institute), Ministry of Agriculture, Yangzhou, ChinaDepartment of Feed and Nutrition, Poultry Institute, Chinese Academy of Agricultural Sciences, Yangzhou, ChinaInstitute of Effective Evaluation of Feed and Feed Additive (Poultry institute), Ministry of Agriculture, Yangzhou, ChinaDepartment of Feed and Nutrition, Poultry Institute, Chinese Academy of Agricultural Sciences, Yangzhou, ChinaInstitute of Effective Evaluation of Feed and Feed Additive (Poultry institute), Ministry of Agriculture, Yangzhou, ChinaDepartment of Feed and Nutrition, Poultry Institute, Chinese Academy of Agricultural Sciences, Yangzhou, ChinaInstitute of Effective Evaluation of Feed and Feed Additive (Poultry institute), Ministry of Agriculture, Yangzhou, ChinaJiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, ChinaAutophagy is an important component of the innate immune system in mammals. Low levels of basic autophagy are sustained in normal cells, to help with the clearance of aging organelles and misfolded proteins, thus maintaining their structural and functional stability. However, when cells are faced with challenges, such as starvation or pathogenic infection, their level of autophagy increases significantly. Salmonella is a facultative intracellular pathogen, which imposes an economic burden on the poultry farming industry and human public health. Previous studies have shown that Salmonella can induce the autophagy of cells following invasion, which to a certain extent helps to protect the cells from bacterial colonization. This review summarizes the latest research in the field of Salmonella-induced autophagy, including: (i) the autophagy induction and escape mechanisms employed by Salmonella during the infection of host cells; (ii) the effect of autophagy on intracellular Salmonella; (iii) the important autophagy adaptors that recognize intracellular Salmonella in host cells; and (iv) the effect of autophagy-modulating drugs on Salmonella infection.https://www.frontiersin.org/article/10.3389/fmicb.2020.00721/fullSalmonellaautophagyxenophagyautophagy adaptordrug regulation
spellingShingle Shu Wu
Shu Wu
Shu Wu
Yiru Shen
Yiru Shen
Shan Zhang
Shan Zhang
Yunqi Xiao
Yunqi Xiao
Shourong Shi
Shourong Shi
Shourong Shi
Salmonella Interacts With Autophagy to Offense or Defense
Frontiers in Microbiology
Salmonella
autophagy
xenophagy
autophagy adaptor
drug regulation
title Salmonella Interacts With Autophagy to Offense or Defense
title_full Salmonella Interacts With Autophagy to Offense or Defense
title_fullStr Salmonella Interacts With Autophagy to Offense or Defense
title_full_unstemmed Salmonella Interacts With Autophagy to Offense or Defense
title_short Salmonella Interacts With Autophagy to Offense or Defense
title_sort salmonella interacts with autophagy to offense or defense
topic Salmonella
autophagy
xenophagy
autophagy adaptor
drug regulation
url https://www.frontiersin.org/article/10.3389/fmicb.2020.00721/full
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