Salmonella Interacts With Autophagy to Offense or Defense
Autophagy is an important component of the innate immune system in mammals. Low levels of basic autophagy are sustained in normal cells, to help with the clearance of aging organelles and misfolded proteins, thus maintaining their structural and functional stability. However, when cells are faced wi...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-04-01
|
Series: | Frontiers in Microbiology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fmicb.2020.00721/full |
_version_ | 1819237389596360704 |
---|---|
author | Shu Wu Shu Wu Shu Wu Yiru Shen Yiru Shen Shan Zhang Shan Zhang Yunqi Xiao Yunqi Xiao Shourong Shi Shourong Shi Shourong Shi |
author_facet | Shu Wu Shu Wu Shu Wu Yiru Shen Yiru Shen Shan Zhang Shan Zhang Yunqi Xiao Yunqi Xiao Shourong Shi Shourong Shi Shourong Shi |
author_sort | Shu Wu |
collection | DOAJ |
description | Autophagy is an important component of the innate immune system in mammals. Low levels of basic autophagy are sustained in normal cells, to help with the clearance of aging organelles and misfolded proteins, thus maintaining their structural and functional stability. However, when cells are faced with challenges, such as starvation or pathogenic infection, their level of autophagy increases significantly. Salmonella is a facultative intracellular pathogen, which imposes an economic burden on the poultry farming industry and human public health. Previous studies have shown that Salmonella can induce the autophagy of cells following invasion, which to a certain extent helps to protect the cells from bacterial colonization. This review summarizes the latest research in the field of Salmonella-induced autophagy, including: (i) the autophagy induction and escape mechanisms employed by Salmonella during the infection of host cells; (ii) the effect of autophagy on intracellular Salmonella; (iii) the important autophagy adaptors that recognize intracellular Salmonella in host cells; and (iv) the effect of autophagy-modulating drugs on Salmonella infection. |
first_indexed | 2024-12-23T13:19:33Z |
format | Article |
id | doaj.art-1ebec871fad64f09a05e6cf64a9fa72a |
institution | Directory Open Access Journal |
issn | 1664-302X |
language | English |
last_indexed | 2024-12-23T13:19:33Z |
publishDate | 2020-04-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Microbiology |
spelling | doaj.art-1ebec871fad64f09a05e6cf64a9fa72a2022-12-21T17:45:30ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2020-04-011110.3389/fmicb.2020.00721515222Salmonella Interacts With Autophagy to Offense or DefenseShu Wu0Shu Wu1Shu Wu2Yiru Shen3Yiru Shen4Shan Zhang5Shan Zhang6Yunqi Xiao7Yunqi Xiao8Shourong Shi9Shourong Shi10Shourong Shi11Department of Feed and Nutrition, Poultry Institute, Chinese Academy of Agricultural Sciences, Yangzhou, ChinaInstitute of Effective Evaluation of Feed and Feed Additive (Poultry institute), Ministry of Agriculture, Yangzhou, ChinaCollege of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaDepartment of Feed and Nutrition, Poultry Institute, Chinese Academy of Agricultural Sciences, Yangzhou, ChinaInstitute of Effective Evaluation of Feed and Feed Additive (Poultry institute), Ministry of Agriculture, Yangzhou, ChinaDepartment of Feed and Nutrition, Poultry Institute, Chinese Academy of Agricultural Sciences, Yangzhou, ChinaInstitute of Effective Evaluation of Feed and Feed Additive (Poultry institute), Ministry of Agriculture, Yangzhou, ChinaDepartment of Feed and Nutrition, Poultry Institute, Chinese Academy of Agricultural Sciences, Yangzhou, ChinaInstitute of Effective Evaluation of Feed and Feed Additive (Poultry institute), Ministry of Agriculture, Yangzhou, ChinaDepartment of Feed and Nutrition, Poultry Institute, Chinese Academy of Agricultural Sciences, Yangzhou, ChinaInstitute of Effective Evaluation of Feed and Feed Additive (Poultry institute), Ministry of Agriculture, Yangzhou, ChinaJiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, ChinaAutophagy is an important component of the innate immune system in mammals. Low levels of basic autophagy are sustained in normal cells, to help with the clearance of aging organelles and misfolded proteins, thus maintaining their structural and functional stability. However, when cells are faced with challenges, such as starvation or pathogenic infection, their level of autophagy increases significantly. Salmonella is a facultative intracellular pathogen, which imposes an economic burden on the poultry farming industry and human public health. Previous studies have shown that Salmonella can induce the autophagy of cells following invasion, which to a certain extent helps to protect the cells from bacterial colonization. This review summarizes the latest research in the field of Salmonella-induced autophagy, including: (i) the autophagy induction and escape mechanisms employed by Salmonella during the infection of host cells; (ii) the effect of autophagy on intracellular Salmonella; (iii) the important autophagy adaptors that recognize intracellular Salmonella in host cells; and (iv) the effect of autophagy-modulating drugs on Salmonella infection.https://www.frontiersin.org/article/10.3389/fmicb.2020.00721/fullSalmonellaautophagyxenophagyautophagy adaptordrug regulation |
spellingShingle | Shu Wu Shu Wu Shu Wu Yiru Shen Yiru Shen Shan Zhang Shan Zhang Yunqi Xiao Yunqi Xiao Shourong Shi Shourong Shi Shourong Shi Salmonella Interacts With Autophagy to Offense or Defense Frontiers in Microbiology Salmonella autophagy xenophagy autophagy adaptor drug regulation |
title | Salmonella Interacts With Autophagy to Offense or Defense |
title_full | Salmonella Interacts With Autophagy to Offense or Defense |
title_fullStr | Salmonella Interacts With Autophagy to Offense or Defense |
title_full_unstemmed | Salmonella Interacts With Autophagy to Offense or Defense |
title_short | Salmonella Interacts With Autophagy to Offense or Defense |
title_sort | salmonella interacts with autophagy to offense or defense |
topic | Salmonella autophagy xenophagy autophagy adaptor drug regulation |
url | https://www.frontiersin.org/article/10.3389/fmicb.2020.00721/full |
work_keys_str_mv | AT shuwu salmonellainteractswithautophagytooffenseordefense AT shuwu salmonellainteractswithautophagytooffenseordefense AT shuwu salmonellainteractswithautophagytooffenseordefense AT yirushen salmonellainteractswithautophagytooffenseordefense AT yirushen salmonellainteractswithautophagytooffenseordefense AT shanzhang salmonellainteractswithautophagytooffenseordefense AT shanzhang salmonellainteractswithautophagytooffenseordefense AT yunqixiao salmonellainteractswithautophagytooffenseordefense AT yunqixiao salmonellainteractswithautophagytooffenseordefense AT shourongshi salmonellainteractswithautophagytooffenseordefense AT shourongshi salmonellainteractswithautophagytooffenseordefense AT shourongshi salmonellainteractswithautophagytooffenseordefense |