Rheopathologic Consequence of Plasmodium vivax Rosette Formation.
Malaria parasites dramatically alter the rheological properties of infected red blood cells. In the case of Plasmodium vivax, the parasite rapidly decreases the shear elastic modulus of the invaded RBC, enabling it to avoid splenic clearance. This study highlights correlation between rosette formati...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-08-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | http://europepmc.org/articles/PMC4980013?pdf=render |
| _version_ | 1828158493991895040 |
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| author | Rou Zhang Wenn-Chyau Lee Yee-Ling Lau Letusa Albrecht Stefanie C P Lopes Fabio T M Costa Rossarin Suwanarusk Francois Nosten Brian M Cooke Laurent Rénia Bruce Russell |
| author_facet | Rou Zhang Wenn-Chyau Lee Yee-Ling Lau Letusa Albrecht Stefanie C P Lopes Fabio T M Costa Rossarin Suwanarusk Francois Nosten Brian M Cooke Laurent Rénia Bruce Russell |
| author_sort | Rou Zhang |
| collection | DOAJ |
| description | Malaria parasites dramatically alter the rheological properties of infected red blood cells. In the case of Plasmodium vivax, the parasite rapidly decreases the shear elastic modulus of the invaded RBC, enabling it to avoid splenic clearance. This study highlights correlation between rosette formation and altered membrane deformability of P. vivax-infected erythrocytes, where the rosette-forming infected erythrocytes are significantly more rigid than their non-rosetting counterparts. The adhesion of normocytes to the PvIRBC is strong (mean binding force of 440pN) resulting in stable rosette formation even under high physiological shear flow stress. Rosetting may contribute to the sequestration of PvIRBC schizonts in the host microvasculature or spleen. |
| first_indexed | 2024-04-11T23:45:08Z |
| format | Article |
| id | doaj.art-1ebef097d4e74182bc640fbc8ddd383f |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-04-11T23:45:08Z |
| publishDate | 2016-08-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-1ebef097d4e74182bc640fbc8ddd383f2022-12-22T03:56:39ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352016-08-01108e000491210.1371/journal.pntd.0004912Rheopathologic Consequence of Plasmodium vivax Rosette Formation.Rou ZhangWenn-Chyau LeeYee-Ling LauLetusa AlbrechtStefanie C P LopesFabio T M CostaRossarin SuwanaruskFrancois NostenBrian M CookeLaurent RéniaBruce RussellMalaria parasites dramatically alter the rheological properties of infected red blood cells. In the case of Plasmodium vivax, the parasite rapidly decreases the shear elastic modulus of the invaded RBC, enabling it to avoid splenic clearance. This study highlights correlation between rosette formation and altered membrane deformability of P. vivax-infected erythrocytes, where the rosette-forming infected erythrocytes are significantly more rigid than their non-rosetting counterparts. The adhesion of normocytes to the PvIRBC is strong (mean binding force of 440pN) resulting in stable rosette formation even under high physiological shear flow stress. Rosetting may contribute to the sequestration of PvIRBC schizonts in the host microvasculature or spleen.http://europepmc.org/articles/PMC4980013?pdf=render |
| spellingShingle | Rou Zhang Wenn-Chyau Lee Yee-Ling Lau Letusa Albrecht Stefanie C P Lopes Fabio T M Costa Rossarin Suwanarusk Francois Nosten Brian M Cooke Laurent Rénia Bruce Russell Rheopathologic Consequence of Plasmodium vivax Rosette Formation. PLoS Neglected Tropical Diseases |
| title | Rheopathologic Consequence of Plasmodium vivax Rosette Formation. |
| title_full | Rheopathologic Consequence of Plasmodium vivax Rosette Formation. |
| title_fullStr | Rheopathologic Consequence of Plasmodium vivax Rosette Formation. |
| title_full_unstemmed | Rheopathologic Consequence of Plasmodium vivax Rosette Formation. |
| title_short | Rheopathologic Consequence of Plasmodium vivax Rosette Formation. |
| title_sort | rheopathologic consequence of plasmodium vivax rosette formation |
| url | http://europepmc.org/articles/PMC4980013?pdf=render |
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