Constructing Asymmetric Polyion Complex Vesicles via Template Assembling Strategy: Formulation Control and Tunable Permeability
A strategy for constructing polyion complex vesicles (PICsomes) with asymmetric structure is described. Poly(methylacrylic acid)-block-poly(N-isopropylacrylamide) modified gold nanoparticles (PMAA-b-PNIPAm-@-Au NPs) were prepared and then assembled with poly(ethylene glycol)-block-poly[1-methyl-3-(2...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-11-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/7/11/387 |
| _version_ | 1819154844343074816 |
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| author | Junbo Li Lijuan Liang Ju Liang Wenlan Wu Huiyun Zhou Jinwu Guo |
| author_facet | Junbo Li Lijuan Liang Ju Liang Wenlan Wu Huiyun Zhou Jinwu Guo |
| author_sort | Junbo Li |
| collection | DOAJ |
| description | A strategy for constructing polyion complex vesicles (PICsomes) with asymmetric structure is described. Poly(methylacrylic acid)-block-poly(N-isopropylacrylamide) modified gold nanoparticles (PMAA-b-PNIPAm-@-Au NPs) were prepared and then assembled with poly(ethylene glycol)-block-poly[1-methyl-3-(2-methacryloyloxy propylimidazolium bromine)] (PEG-b-PMMPImB) via polyion complex of PMMA and PMMPImB. After removing the Au NPs template, asymmetric PICsomes composed of a PNIPAm inner-shell, PIC wall, and PEG outer-corona were obtained. These PICsomes have low protein absorption and thermally tunable permeability, provided by the PEG outer-corona and the PNIPAm inner-shell, respectively. Moreover, PICsome size can be tailored by using templates of predetermined sizes. This novel strategy for constructing asymmetric PICsomes with well-defined properties and controllable size is valuable for applications such as drug delivery, catalysis and monitoring of chemical reactions, and biomimetics. |
| first_indexed | 2024-12-22T15:27:32Z |
| format | Article |
| id | doaj.art-1ec2cd22c6cf48da806af0d2ac00b601 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-12-22T15:27:32Z |
| publishDate | 2017-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-1ec2cd22c6cf48da806af0d2ac00b6012022-12-21T18:21:26ZengMDPI AGNanomaterials2079-49912017-11-0171138710.3390/nano7110387nano7110387Constructing Asymmetric Polyion Complex Vesicles via Template Assembling Strategy: Formulation Control and Tunable PermeabilityJunbo Li0Lijuan Liang1Ju Liang2Wenlan Wu3Huiyun Zhou4Jinwu Guo5School of Chemical Engineering & Pharmaceutics, Henan University of Science & Technology, 263# Kaiyuan Road, Luoyang 471023, ChinaSchool of Chemical Engineering & Pharmaceutics, Henan University of Science & Technology, 263# Kaiyuan Road, Luoyang 471023, ChinaSchool of Chemical Engineering & Pharmaceutics, Henan University of Science & Technology, 263# Kaiyuan Road, Luoyang 471023, ChinaSchool of Medicine, Henan University of Science & Technology, 263# Kaiyuan Road, Luoyang 471023, ChinaSchool of Chemical Engineering & Pharmaceutics, Henan University of Science & Technology, 263# Kaiyuan Road, Luoyang 471023, ChinaSchool of Chemical Engineering & Pharmaceutics, Henan University of Science & Technology, 263# Kaiyuan Road, Luoyang 471023, ChinaA strategy for constructing polyion complex vesicles (PICsomes) with asymmetric structure is described. Poly(methylacrylic acid)-block-poly(N-isopropylacrylamide) modified gold nanoparticles (PMAA-b-PNIPAm-@-Au NPs) were prepared and then assembled with poly(ethylene glycol)-block-poly[1-methyl-3-(2-methacryloyloxy propylimidazolium bromine)] (PEG-b-PMMPImB) via polyion complex of PMMA and PMMPImB. After removing the Au NPs template, asymmetric PICsomes composed of a PNIPAm inner-shell, PIC wall, and PEG outer-corona were obtained. These PICsomes have low protein absorption and thermally tunable permeability, provided by the PEG outer-corona and the PNIPAm inner-shell, respectively. Moreover, PICsome size can be tailored by using templates of predetermined sizes. This novel strategy for constructing asymmetric PICsomes with well-defined properties and controllable size is valuable for applications such as drug delivery, catalysis and monitoring of chemical reactions, and biomimetics.https://www.mdpi.com/2079-4991/7/11/387asymmetric polymersomepolyion complexblock copolymergold templatepermeability |
| spellingShingle | Junbo Li Lijuan Liang Ju Liang Wenlan Wu Huiyun Zhou Jinwu Guo Constructing Asymmetric Polyion Complex Vesicles via Template Assembling Strategy: Formulation Control and Tunable Permeability Nanomaterials asymmetric polymersome polyion complex block copolymer gold template permeability |
| title | Constructing Asymmetric Polyion Complex Vesicles via Template Assembling Strategy: Formulation Control and Tunable Permeability |
| title_full | Constructing Asymmetric Polyion Complex Vesicles via Template Assembling Strategy: Formulation Control and Tunable Permeability |
| title_fullStr | Constructing Asymmetric Polyion Complex Vesicles via Template Assembling Strategy: Formulation Control and Tunable Permeability |
| title_full_unstemmed | Constructing Asymmetric Polyion Complex Vesicles via Template Assembling Strategy: Formulation Control and Tunable Permeability |
| title_short | Constructing Asymmetric Polyion Complex Vesicles via Template Assembling Strategy: Formulation Control and Tunable Permeability |
| title_sort | constructing asymmetric polyion complex vesicles via template assembling strategy formulation control and tunable permeability |
| topic | asymmetric polymersome polyion complex block copolymer gold template permeability |
| url | https://www.mdpi.com/2079-4991/7/11/387 |
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