Fatty Acid Allosteric Regulation of C-H Activation in Plant and Animal Lipoxygenases
Lipoxygenases (LOXs) catalyze the (per) oxidation of fatty acids that serve as important mediators for cell signaling and inflammation. These reactions are initiated by a C-H activation step that is allosterically regulated in plant and animal enzymes. LOXs from higher eukaryotes are equipped with a...
Main Authors: | Adam R. Offenbacher, Theodore R. Holman |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-07-01
|
Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/25/15/3374 |
Similar Items
-
GTP-Dependent Regulation of CTP Synthase: Evolving Insights into Allosteric Activation and NH<sub>3</sub> Translocation
by: Stephen L. Bearne, et al.
Published: (2022-04-01) -
Temperature as a modulator of allosteric motions and crosstalk in mesophilic and thermophilic enzymes
by: Alexa L. Knight, et al.
Published: (2023-10-01) -
Tunneling in the Hydrogen-Transfer Reaction from a Vitamin E Analog to an Inclusion Complex of 2,2-Diphenyl-1-picrylhydrazyl Radical with β-Cyclodextrin in an Aqueous Buffer Solution at Ambient Temperature
by: Ikuo Nakanishi, et al.
Published: (2021-12-01) -
Enhanced specificity mutations perturb allosteric signaling in CRISPR-Cas9
by: Lukasz Nierzwicki, et al.
Published: (2021-12-01) -
An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering
by: Daniel A Keedy, et al.
Published: (2018-06-01)