The Potential Contribution of ABO, Lewis and Secretor Histo-Blood Group Carbohydrates in Infection by Toxoplasma gondii
The glycosyltransferases encoded by genes from the human ABO, Lewis, and Secretor histo-blood group systems synthesize part of the carbohydrate antigens in hematopoietic and non-hematopoietic tissues. The combined action of these glycosyltransferases strongly influences cell, tissue, mucosa, and exo...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2021.671958/full |
| _version_ | 1829485615535620096 |
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| author | Luiz Carlos De Mattos Ana Iara Costa Ferreira Karina Younan de Oliveira Fabiana Nakashima Cinara Cássia Brandão Cinara Cássia Brandão |
| author_facet | Luiz Carlos De Mattos Ana Iara Costa Ferreira Karina Younan de Oliveira Fabiana Nakashima Cinara Cássia Brandão Cinara Cássia Brandão |
| author_sort | Luiz Carlos De Mattos |
| collection | DOAJ |
| description | The glycosyltransferases encoded by genes from the human ABO, Lewis, and Secretor histo-blood group systems synthesize part of the carbohydrate antigens in hematopoietic and non-hematopoietic tissues. The combined action of these glycosyltransferases strongly influences cell, tissue, mucosa, and exocrine secretion carbohydrate phenotypes, including those serving as habitat for mutualistic and pathogenic microorganisms. A set of reports investigated associations between Toxoplasma gondii infection and the ABO histo-blood group system, but the results are contradictory. As T. gondii uses the gastrointestinal tract as a route for infection, and in this organ, the expression of ABO, Lewis, and Secretor histo-blood group carbohydrates occurs, it is reasonable to suppose some biological relationship between them. This text reviewed association studies published in recent decades focusing on the potential contribution of the ABO, Lewis, and Secretor histo-blood group carbohydrates and infection by T. gondii. |
| first_indexed | 2024-12-14T22:48:41Z |
| format | Article |
| id | doaj.art-1ec616a5104943458c57bc4d709f78c9 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-14T22:48:41Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-1ec616a5104943458c57bc4d709f78c92022-12-21T22:44:46ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882021-06-011110.3389/fcimb.2021.671958671958The Potential Contribution of ABO, Lewis and Secretor Histo-Blood Group Carbohydrates in Infection by Toxoplasma gondiiLuiz Carlos De Mattos0Ana Iara Costa Ferreira1Karina Younan de Oliveira2Fabiana Nakashima3Cinara Cássia Brandão4Cinara Cássia Brandão5Immunogenetics Laboratory, Molecular Biology Department, Faculty of Medicine – FAMERP, São José do Rio Preto, BrazilImmunogenetics Laboratory, Molecular Biology Department, Faculty of Medicine – FAMERP, São José do Rio Preto, BrazilImmunogenetics Laboratory, Molecular Biology Department, Faculty of Medicine – FAMERP, São José do Rio Preto, BrazilImmunogenetics Laboratory, Molecular Biology Department, Faculty of Medicine – FAMERP, São José do Rio Preto, BrazilImmunogenetics Laboratory, Molecular Biology Department, Faculty of Medicine – FAMERP, São José do Rio Preto, BrazilFAMERP Toxoplasma Research Group, Molecular Biology Department, Faculty of Medicine – FAMERP, São José do Rio Preto, BrazilThe glycosyltransferases encoded by genes from the human ABO, Lewis, and Secretor histo-blood group systems synthesize part of the carbohydrate antigens in hematopoietic and non-hematopoietic tissues. The combined action of these glycosyltransferases strongly influences cell, tissue, mucosa, and exocrine secretion carbohydrate phenotypes, including those serving as habitat for mutualistic and pathogenic microorganisms. A set of reports investigated associations between Toxoplasma gondii infection and the ABO histo-blood group system, but the results are contradictory. As T. gondii uses the gastrointestinal tract as a route for infection, and in this organ, the expression of ABO, Lewis, and Secretor histo-blood group carbohydrates occurs, it is reasonable to suppose some biological relationship between them. This text reviewed association studies published in recent decades focusing on the potential contribution of the ABO, Lewis, and Secretor histo-blood group carbohydrates and infection by T. gondii.https://www.frontiersin.org/articles/10.3389/fcimb.2021.671958/fullhisto-blood group systemscarbohydratessecretorlewis phenotypesecretor phenotypeABO blood group |
| spellingShingle | Luiz Carlos De Mattos Ana Iara Costa Ferreira Karina Younan de Oliveira Fabiana Nakashima Cinara Cássia Brandão Cinara Cássia Brandão The Potential Contribution of ABO, Lewis and Secretor Histo-Blood Group Carbohydrates in Infection by Toxoplasma gondii Frontiers in Cellular and Infection Microbiology histo-blood group systems carbohydrates secretor lewis phenotype secretor phenotype ABO blood group |
| title | The Potential Contribution of ABO, Lewis and Secretor Histo-Blood Group Carbohydrates in Infection by Toxoplasma gondii |
| title_full | The Potential Contribution of ABO, Lewis and Secretor Histo-Blood Group Carbohydrates in Infection by Toxoplasma gondii |
| title_fullStr | The Potential Contribution of ABO, Lewis and Secretor Histo-Blood Group Carbohydrates in Infection by Toxoplasma gondii |
| title_full_unstemmed | The Potential Contribution of ABO, Lewis and Secretor Histo-Blood Group Carbohydrates in Infection by Toxoplasma gondii |
| title_short | The Potential Contribution of ABO, Lewis and Secretor Histo-Blood Group Carbohydrates in Infection by Toxoplasma gondii |
| title_sort | potential contribution of abo lewis and secretor histo blood group carbohydrates in infection by toxoplasma gondii |
| topic | histo-blood group systems carbohydrates secretor lewis phenotype secretor phenotype ABO blood group |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2021.671958/full |
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