What is the role of spatial processing in the decline of episodic memory in Alzheimer's disease? The "mental frame syncing" hypothesis
The current theories on episodic memory suggest a crucial role of spatial processing for an effective retrieval. When prompted by a retrieval cue, the full past scene can be retrieved through the process of pattern completion. Thanks to retrosplenial cortex, this allocentric representation is trans...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014-03-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00033/full |
| _version_ | 1828340654194819072 |
|---|---|
| author | Silvia eSerino Giuseppe eRiva Giuseppe eRiva |
| author_facet | Silvia eSerino Giuseppe eRiva Giuseppe eRiva |
| author_sort | Silvia eSerino |
| collection | DOAJ |
| description | The current theories on episodic memory suggest a crucial role of spatial processing for an effective retrieval. When prompted by a retrieval cue, the full past scene can be retrieved through the process of pattern completion. Thanks to retrosplenial cortex, this allocentric representation is translated to an egocentric representation in the medial parietal areas via information updating from other cells: place cells inform the viewpoint location, head-direction cells the viewing direction, and grid cells the self-motion signals. Based on several evidence, we argue that a crucial role for an episodic retrieval is played by a "mental frame syncing" between the allocentric view-point dependent representation and the allocentric view-point independent representation. If the mental frame syncing stops, even momentarily, it is difficult to reconstruct a coherent representation for an effective episodic recall. This is what apparently happens in Alzheimer's disease: a break in the mental frame syncing between these two kinds of allocentric representations, underpinned by damage to the hippocampus, may contribute significantly to the early deficit in episodic memory. |
| first_indexed | 2024-04-13T22:59:17Z |
| format | Article |
| id | doaj.art-1ec89224a8cb43b0aa84403039ecfff4 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-13T22:59:17Z |
| publishDate | 2014-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-1ec89224a8cb43b0aa84403039ecfff42022-12-22T02:25:53ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652014-03-01610.3389/fnagi.2014.0003372386What is the role of spatial processing in the decline of episodic memory in Alzheimer's disease? The "mental frame syncing" hypothesisSilvia eSerino0Giuseppe eRiva1Giuseppe eRiva2I.R.C.C.S ISTITUTO AUXOLOGICO ITALIANOI.R.C.C.S ISTITUTO AUXOLOGICO ITALIANOUniversità Cattolica del Sacro CuoreThe current theories on episodic memory suggest a crucial role of spatial processing for an effective retrieval. When prompted by a retrieval cue, the full past scene can be retrieved through the process of pattern completion. Thanks to retrosplenial cortex, this allocentric representation is translated to an egocentric representation in the medial parietal areas via information updating from other cells: place cells inform the viewpoint location, head-direction cells the viewing direction, and grid cells the self-motion signals. Based on several evidence, we argue that a crucial role for an episodic retrieval is played by a "mental frame syncing" between the allocentric view-point dependent representation and the allocentric view-point independent representation. If the mental frame syncing stops, even momentarily, it is difficult to reconstruct a coherent representation for an effective episodic recall. This is what apparently happens in Alzheimer's disease: a break in the mental frame syncing between these two kinds of allocentric representations, underpinned by damage to the hippocampus, may contribute significantly to the early deficit in episodic memory.http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00033/fullAlzheimer's diseasespatial cognitionepisodic memoryegocentric frame of referenceallocentric frame of reference |
| spellingShingle | Silvia eSerino Giuseppe eRiva Giuseppe eRiva What is the role of spatial processing in the decline of episodic memory in Alzheimer's disease? The "mental frame syncing" hypothesis Frontiers in Aging Neuroscience Alzheimer's disease spatial cognition episodic memory egocentric frame of reference allocentric frame of reference |
| title | What is the role of spatial processing in the decline of episodic memory in Alzheimer's disease? The "mental frame syncing" hypothesis |
| title_full | What is the role of spatial processing in the decline of episodic memory in Alzheimer's disease? The "mental frame syncing" hypothesis |
| title_fullStr | What is the role of spatial processing in the decline of episodic memory in Alzheimer's disease? The "mental frame syncing" hypothesis |
| title_full_unstemmed | What is the role of spatial processing in the decline of episodic memory in Alzheimer's disease? The "mental frame syncing" hypothesis |
| title_short | What is the role of spatial processing in the decline of episodic memory in Alzheimer's disease? The "mental frame syncing" hypothesis |
| title_sort | what is the role of spatial processing in the decline of episodic memory in alzheimer 39 s disease the quot mental frame syncing quot hypothesis |
| topic | Alzheimer's disease spatial cognition episodic memory egocentric frame of reference allocentric frame of reference |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00033/full |
| work_keys_str_mv | AT silviaeserino whatistheroleofspatialprocessinginthedeclineofepisodicmemoryinalzheimer39sdiseasethequotmentalframesyncingquothypothesis AT giuseppeeriva whatistheroleofspatialprocessinginthedeclineofepisodicmemoryinalzheimer39sdiseasethequotmentalframesyncingquothypothesis AT giuseppeeriva whatistheroleofspatialprocessinginthedeclineofepisodicmemoryinalzheimer39sdiseasethequotmentalframesyncingquothypothesis |