Is Vitamin D3 a Worthy Supplement Protecting against Secondary Infections in Dogs with Atopic Dermatitis?
Canine atopic dermatitis (CAD) is a common, chronic, inflammatory skin disease in dogs worldwide. This disease often predisposes for secondary organisms overgrowth and skin infections with pathogens, such as <i>Staphylococcus pseudintermedius</i> and <i>Malassezia pachydermatis<...
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MDPI AG
2023-01-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/12/1/145 |
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| author | Dorota Chrobak-Chmiel Anna Golke Ewelina Kwiecień Małgorzata J. Biegańska Kourou Dembele Małgorzata Dziekiewicz-Mrugasiewicz Michał Czopowicz Magdalena Kizerwetter-Świda Magdalena Rzewuska |
| author_facet | Dorota Chrobak-Chmiel Anna Golke Ewelina Kwiecień Małgorzata J. Biegańska Kourou Dembele Małgorzata Dziekiewicz-Mrugasiewicz Michał Czopowicz Magdalena Kizerwetter-Świda Magdalena Rzewuska |
| author_sort | Dorota Chrobak-Chmiel |
| collection | DOAJ |
| description | Canine atopic dermatitis (CAD) is a common, chronic, inflammatory skin disease in dogs worldwide. This disease often predisposes for secondary organisms overgrowth and skin infections with pathogens, such as <i>Staphylococcus pseudintermedius</i> and <i>Malassezia pachydermatis</i>. Unfortunately, the causes of this disease in both humans and animals are not fully understood; therefore, the only possible option is a lifelong, symptomatic treatment. The management of CAD is mainly based on limiting contact with allergens and antipruritic therapy, most often with glucocorticoids and antihistamines. A serious problem in this situation is the fact, that long-term administration of glucocorticoids leads to side effects like polyuria, alopecia, increased susceptibility to infection, muscle atrophy, and many others. For this reason, great emphasis is placed on the development of replacement and supportive therapies. It is a well-documented fact that reduced concentrations of serum vitamin D3 contribute to the severity of atopic dermatitis symptoms in humans. Moreover, unlike the most commonly used therapeutic methods, of which the main goal is to ameliorate inflammation and pruritus, namely the symptoms of AD, vitamin D3 supplementation affects some underlying factors of this disease. Therefore, in this review, we summarize the current state of knowledge regarding the role of vitamin D3 in CAD, its protective effect against secondary bacterial and fungal infections, and the potential of its supplementation in dogs. |
| first_indexed | 2024-03-09T11:29:14Z |
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| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-09T11:29:14Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-1ec935125aa04e34832b859b25ebe0b32023-11-30T23:54:19ZengMDPI AGPathogens2076-08172023-01-0112114510.3390/pathogens12010145Is Vitamin D3 a Worthy Supplement Protecting against Secondary Infections in Dogs with Atopic Dermatitis?Dorota Chrobak-Chmiel0Anna Golke1Ewelina Kwiecień2Małgorzata J. Biegańska3Kourou Dembele4Małgorzata Dziekiewicz-Mrugasiewicz5Michał Czopowicz6Magdalena Kizerwetter-Świda7Magdalena Rzewuska8Department of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Ciszewskiego 8, 02-786 Warsaw, PolandDepartment of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Ciszewskiego 8, 02-786 Warsaw, PolandDepartment of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Ciszewskiego 8, 02-786 Warsaw, PolandDepartment of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Ciszewskiego 8, 02-786 Warsaw, PolandDepartment of Small Animal Diseases and Clinic, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 159c, 02-776 Warsaw, PolandDepartment of Large Animal Diseases with Clinic, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 100, 02-797 Warsaw, PolandDivision of Veterinary Epidemiology and Economics, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 159c, 02-776 Warsaw, PolandDepartment of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Ciszewskiego 8, 02-786 Warsaw, PolandDepartment of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Ciszewskiego 8, 02-786 Warsaw, PolandCanine atopic dermatitis (CAD) is a common, chronic, inflammatory skin disease in dogs worldwide. This disease often predisposes for secondary organisms overgrowth and skin infections with pathogens, such as <i>Staphylococcus pseudintermedius</i> and <i>Malassezia pachydermatis</i>. Unfortunately, the causes of this disease in both humans and animals are not fully understood; therefore, the only possible option is a lifelong, symptomatic treatment. The management of CAD is mainly based on limiting contact with allergens and antipruritic therapy, most often with glucocorticoids and antihistamines. A serious problem in this situation is the fact, that long-term administration of glucocorticoids leads to side effects like polyuria, alopecia, increased susceptibility to infection, muscle atrophy, and many others. For this reason, great emphasis is placed on the development of replacement and supportive therapies. It is a well-documented fact that reduced concentrations of serum vitamin D3 contribute to the severity of atopic dermatitis symptoms in humans. Moreover, unlike the most commonly used therapeutic methods, of which the main goal is to ameliorate inflammation and pruritus, namely the symptoms of AD, vitamin D3 supplementation affects some underlying factors of this disease. Therefore, in this review, we summarize the current state of knowledge regarding the role of vitamin D3 in CAD, its protective effect against secondary bacterial and fungal infections, and the potential of its supplementation in dogs.https://www.mdpi.com/2076-0817/12/1/145canine atopic dermatitisvitamin D3antimicrobial peptides<i>Staphylococcus pseudintermedius</i><i>Malassezia pachydermatis</i> |
| spellingShingle | Dorota Chrobak-Chmiel Anna Golke Ewelina Kwiecień Małgorzata J. Biegańska Kourou Dembele Małgorzata Dziekiewicz-Mrugasiewicz Michał Czopowicz Magdalena Kizerwetter-Świda Magdalena Rzewuska Is Vitamin D3 a Worthy Supplement Protecting against Secondary Infections in Dogs with Atopic Dermatitis? Pathogens canine atopic dermatitis vitamin D3 antimicrobial peptides <i>Staphylococcus pseudintermedius</i> <i>Malassezia pachydermatis</i> |
| title | Is Vitamin D3 a Worthy Supplement Protecting against Secondary Infections in Dogs with Atopic Dermatitis? |
| title_full | Is Vitamin D3 a Worthy Supplement Protecting against Secondary Infections in Dogs with Atopic Dermatitis? |
| title_fullStr | Is Vitamin D3 a Worthy Supplement Protecting against Secondary Infections in Dogs with Atopic Dermatitis? |
| title_full_unstemmed | Is Vitamin D3 a Worthy Supplement Protecting against Secondary Infections in Dogs with Atopic Dermatitis? |
| title_short | Is Vitamin D3 a Worthy Supplement Protecting against Secondary Infections in Dogs with Atopic Dermatitis? |
| title_sort | is vitamin d3 a worthy supplement protecting against secondary infections in dogs with atopic dermatitis |
| topic | canine atopic dermatitis vitamin D3 antimicrobial peptides <i>Staphylococcus pseudintermedius</i> <i>Malassezia pachydermatis</i> |
| url | https://www.mdpi.com/2076-0817/12/1/145 |
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