Identification of Plakortide E from the Caribbean Sponge Plakortis halichondroides as a Trypanocidal Protease Inhibitor using Bioactivity-Guided Fractionation

Identification of Plakortide E from the Caribbean Sponge Plakortis halichondroides as a Trypanocidal Protease Inhibitor using Bioactivity-Guided Fractionation

In this paper, we report new protease inhibitory activity of plakortide E towards cathepsins and cathepsin-like parasitic proteases. We further report on its anti-parasitic activity against Trypanosoma brucei with an IC50 value of 5 μM and without cytotoxic effects against J774.1 macrophages at 100...

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Bibliographic Details
Main Authors: Swarna Oli, Usama Ramadan Abdelmohsen, Ute Hentschel, Tanja Schirmeister
Format: Article
Language:English
Published: MDPI AG 2014-05-01
Series:Marine Drugs
Subjects:
Plakortis halichondroides
plakortide E
protease inhibitor
slowly-binding reversible inhibitor
cathepsin
rhodesain
Online Access:http://www.mdpi.com/1660-3397/12/5/2614

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