Basic research and clinical exploration of cold atmospheric plasma for skin wounds
Abstract Skin wounds, such as burns, diabetic foot ulcers, pressure sores, and wounds formed after laser or surgical treatment, comprise a very high proportion of dermatological disorders. Wounds are treated in a variety of ways; however, some wounds are greatly resistant, resulting in delayed heali...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-09-01
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| Series: | Bioengineering & Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/btm2.10550 |
| _version_ | 1797689753033768960 |
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| author | Miaomiao Li Jing Gao Liyun Wang Jia Liu Chuyu Fu Xingyu Yang Shengquan Zhang Xinwei Li Shengyong Luo Chunjun Yang |
| author_facet | Miaomiao Li Jing Gao Liyun Wang Jia Liu Chuyu Fu Xingyu Yang Shengquan Zhang Xinwei Li Shengyong Luo Chunjun Yang |
| author_sort | Miaomiao Li |
| collection | DOAJ |
| description | Abstract Skin wounds, such as burns, diabetic foot ulcers, pressure sores, and wounds formed after laser or surgical treatment, comprise a very high proportion of dermatological disorders. Wounds are treated in a variety of ways; however, some wounds are greatly resistant, resulting in delayed healing and an urgent need to introduce new alternatives. Our previous studies have shown that cold atmospheric plasma (CAP) has antibacterial activity and promotes cell proliferation, differentiation, and migration in vitro. To further advance the role of CAP in wound healing, we evaluated the safety and efficacy of CAP in vitro by irradiation of common refractory bacteria on the skin, irradiation of normal skin of rats and observing reactions, treatment of scald wounds in rats, and treating clinically common acute wounds. Our findings revealed that CAP can eliminate refractory skin bacteria in vitro; CAP positively affected wound healing in a rat scalding wound model; and direct CAP irradiation of low intensity and short duration did not lead to skin erythema or edema. CAP promises to be a new, economical, and safe means of wound treatment. |
| first_indexed | 2024-03-12T01:50:59Z |
| format | Article |
| id | doaj.art-1ecb4f2f8d704dc5b1150b7e7aa541a2 |
| institution | Directory Open Access Journal |
| issn | 2380-6761 |
| language | English |
| last_indexed | 2024-03-12T01:50:59Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioengineering & Translational Medicine |
| spelling | doaj.art-1ecb4f2f8d704dc5b1150b7e7aa541a22023-09-08T13:29:53ZengWileyBioengineering & Translational Medicine2380-67612023-09-0185n/an/a10.1002/btm2.10550Basic research and clinical exploration of cold atmospheric plasma for skin woundsMiaomiao Li0Jing Gao1Liyun Wang2Jia Liu3Chuyu Fu4Xingyu Yang5Shengquan Zhang6Xinwei Li7Shengyong Luo8Chunjun Yang9Department of Dermatology and Venereology the Second Affiliated Hospital of Anhui Medical University Hefei Anhui ChinaDepartment of Dermatology and Venereology the Second Affiliated Hospital of Anhui Medical University Hefei Anhui ChinaDepartment of Dermatology and Venereology the Second Affiliated Hospital of Anhui Medical University Hefei Anhui ChinaDepartment of Dermatology and Venereology the Second Affiliated Hospital of Anhui Medical University Hefei Anhui ChinaDepartment of Dermatology and Venereology the Second Affiliated Hospital of Anhui Medical University Hefei Anhui ChinaDepartment of Dermatology and Venereology the Second Affiliated Hospital of Anhui Medical University Hefei Anhui ChinaAnhui Provincial Institute of Translational Medicine Hefei Anhui ChinaAnhui Academy of Medical Sciences Hefei Anhui ChinaAnhui Academy of Medical Sciences Hefei Anhui ChinaDepartment of Dermatology and Venereology the Second Affiliated Hospital of Anhui Medical University Hefei Anhui ChinaAbstract Skin wounds, such as burns, diabetic foot ulcers, pressure sores, and wounds formed after laser or surgical treatment, comprise a very high proportion of dermatological disorders. Wounds are treated in a variety of ways; however, some wounds are greatly resistant, resulting in delayed healing and an urgent need to introduce new alternatives. Our previous studies have shown that cold atmospheric plasma (CAP) has antibacterial activity and promotes cell proliferation, differentiation, and migration in vitro. To further advance the role of CAP in wound healing, we evaluated the safety and efficacy of CAP in vitro by irradiation of common refractory bacteria on the skin, irradiation of normal skin of rats and observing reactions, treatment of scald wounds in rats, and treating clinically common acute wounds. Our findings revealed that CAP can eliminate refractory skin bacteria in vitro; CAP positively affected wound healing in a rat scalding wound model; and direct CAP irradiation of low intensity and short duration did not lead to skin erythema or edema. CAP promises to be a new, economical, and safe means of wound treatment.https://doi.org/10.1002/btm2.10550basic researchclinical explorationcold atmospheric plasmawound healing |
| spellingShingle | Miaomiao Li Jing Gao Liyun Wang Jia Liu Chuyu Fu Xingyu Yang Shengquan Zhang Xinwei Li Shengyong Luo Chunjun Yang Basic research and clinical exploration of cold atmospheric plasma for skin wounds Bioengineering & Translational Medicine basic research clinical exploration cold atmospheric plasma wound healing |
| title | Basic research and clinical exploration of cold atmospheric plasma for skin wounds |
| title_full | Basic research and clinical exploration of cold atmospheric plasma for skin wounds |
| title_fullStr | Basic research and clinical exploration of cold atmospheric plasma for skin wounds |
| title_full_unstemmed | Basic research and clinical exploration of cold atmospheric plasma for skin wounds |
| title_short | Basic research and clinical exploration of cold atmospheric plasma for skin wounds |
| title_sort | basic research and clinical exploration of cold atmospheric plasma for skin wounds |
| topic | basic research clinical exploration cold atmospheric plasma wound healing |
| url | https://doi.org/10.1002/btm2.10550 |
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