Circadian Clock Regulation of Hepatic Energy Metabolism Regulatory Circuits
The liver is a critical organ of energy metabolism. At least 10% of the liver transcriptome demonstrates rhythmic expression, implying that the circadian clock regulates large programmes of hepatic genes. Here, we review the mechanisms by which this rhythmic regulation is conferred, with a particula...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-10-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/8/4/79 |
| _version_ | 1797728809730965504 |
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| author | Ann Louise Hunter David W. Ray |
| author_facet | Ann Louise Hunter David W. Ray |
| author_sort | Ann Louise Hunter |
| collection | DOAJ |
| description | The liver is a critical organ of energy metabolism. At least 10% of the liver transcriptome demonstrates rhythmic expression, implying that the circadian clock regulates large programmes of hepatic genes. Here, we review the mechanisms by which this rhythmic regulation is conferred, with a particular focus on the transcription factors whose actions combine to impart liver- and time-specificity to metabolic gene expression. |
| first_indexed | 2024-03-12T11:19:29Z |
| format | Article |
| id | doaj.art-1ecbdaf4c0c540ce9b1becbdb96904e6 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-12T11:19:29Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-1ecbdaf4c0c540ce9b1becbdb96904e62023-09-02T00:54:17ZengMDPI AGBiology2079-77372019-10-01847910.3390/biology8040079biology8040079Circadian Clock Regulation of Hepatic Energy Metabolism Regulatory CircuitsAnn Louise Hunter0David W. Ray1Centre for Biological Timing, Department of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UKNIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK and Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 9DU, UKThe liver is a critical organ of energy metabolism. At least 10% of the liver transcriptome demonstrates rhythmic expression, implying that the circadian clock regulates large programmes of hepatic genes. Here, we review the mechanisms by which this rhythmic regulation is conferred, with a particular focus on the transcription factors whose actions combine to impart liver- and time-specificity to metabolic gene expression.https://www.mdpi.com/2079-7737/8/4/79circadian clockbiological rhythmsenergy metabolismliverrev-erbαcryptochrome |
| spellingShingle | Ann Louise Hunter David W. Ray Circadian Clock Regulation of Hepatic Energy Metabolism Regulatory Circuits Biology circadian clock biological rhythms energy metabolism liver rev-erbα cryptochrome |
| title | Circadian Clock Regulation of Hepatic Energy Metabolism Regulatory Circuits |
| title_full | Circadian Clock Regulation of Hepatic Energy Metabolism Regulatory Circuits |
| title_fullStr | Circadian Clock Regulation of Hepatic Energy Metabolism Regulatory Circuits |
| title_full_unstemmed | Circadian Clock Regulation of Hepatic Energy Metabolism Regulatory Circuits |
| title_short | Circadian Clock Regulation of Hepatic Energy Metabolism Regulatory Circuits |
| title_sort | circadian clock regulation of hepatic energy metabolism regulatory circuits |
| topic | circadian clock biological rhythms energy metabolism liver rev-erbα cryptochrome |
| url | https://www.mdpi.com/2079-7737/8/4/79 |
| work_keys_str_mv | AT annlouisehunter circadianclockregulationofhepaticenergymetabolismregulatorycircuits AT davidwray circadianclockregulationofhepaticenergymetabolismregulatorycircuits |