Changes in extracellular matrix (ECM) and ECM-associated proteins in the metastatic progression of prostate cancer
<p>Abstract</p> <p>Prostate cancer (PCa) is no exception to the multi-step process of metastasis. As PCa progresses, changes occur within the microenvironments of both the malignant cells and their targeted site of metastasis, enabling the necessary responses that result in success...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2004-01-01
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| Series: | Reproductive Biology and Endocrinology |
| Online Access: | http://www.rbej.com/content/2/1/2 |
| _version_ | 1811266448364929024 |
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| author | Sikes Robert A Cooper Carlton R Stewart Delisha A |
| author_facet | Sikes Robert A Cooper Carlton R Stewart Delisha A |
| author_sort | Sikes Robert A |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Prostate cancer (PCa) is no exception to the multi-step process of metastasis. As PCa progresses, changes occur within the microenvironments of both the malignant cells and their targeted site of metastasis, enabling the necessary responses that result in successful translocation. The majority of patients with progressing prostate cancers develop skeletal metastases. Despite advancing efforts in early detection and management, there remains no effective, long-term cure for metastatic PCa. Therefore, the elucidation of the mechanism of PCa metastasis and preferential establishment of lesions in bone is an intensive area of investigation that promises to generate new targets for therapeutic intervention. This review will survey what is currently know concerning PCa interaction with the extracellular matrix (ECM) and the roles of factors within the tumor and ECM microenvironments that contribute to metastasis. These will be discussed within the context of changes in expression and functional heterodimerization patterns of integrins, changes in ECM expression and reorganization by proteases facilitating invasion. In this context we also provide a brief summary of how growth factors (GFs), cytokines and regulatory signaling pathways favor PCa metastasis to bone.</p> |
| first_indexed | 2024-04-12T20:42:27Z |
| format | Article |
| id | doaj.art-1eccc444fe76432d9b6e57163f6c77fd |
| institution | Directory Open Access Journal |
| issn | 1477-7827 |
| language | English |
| last_indexed | 2024-04-12T20:42:27Z |
| publishDate | 2004-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj.art-1eccc444fe76432d9b6e57163f6c77fd2022-12-22T03:17:22ZengBMCReproductive Biology and Endocrinology1477-78272004-01-01212Changes in extracellular matrix (ECM) and ECM-associated proteins in the metastatic progression of prostate cancerSikes Robert ACooper Carlton RStewart Delisha A<p>Abstract</p> <p>Prostate cancer (PCa) is no exception to the multi-step process of metastasis. As PCa progresses, changes occur within the microenvironments of both the malignant cells and their targeted site of metastasis, enabling the necessary responses that result in successful translocation. The majority of patients with progressing prostate cancers develop skeletal metastases. Despite advancing efforts in early detection and management, there remains no effective, long-term cure for metastatic PCa. Therefore, the elucidation of the mechanism of PCa metastasis and preferential establishment of lesions in bone is an intensive area of investigation that promises to generate new targets for therapeutic intervention. This review will survey what is currently know concerning PCa interaction with the extracellular matrix (ECM) and the roles of factors within the tumor and ECM microenvironments that contribute to metastasis. These will be discussed within the context of changes in expression and functional heterodimerization patterns of integrins, changes in ECM expression and reorganization by proteases facilitating invasion. In this context we also provide a brief summary of how growth factors (GFs), cytokines and regulatory signaling pathways favor PCa metastasis to bone.</p>http://www.rbej.com/content/2/1/2 |
| spellingShingle | Sikes Robert A Cooper Carlton R Stewart Delisha A Changes in extracellular matrix (ECM) and ECM-associated proteins in the metastatic progression of prostate cancer Reproductive Biology and Endocrinology |
| title | Changes in extracellular matrix (ECM) and ECM-associated proteins in the metastatic progression of prostate cancer |
| title_full | Changes in extracellular matrix (ECM) and ECM-associated proteins in the metastatic progression of prostate cancer |
| title_fullStr | Changes in extracellular matrix (ECM) and ECM-associated proteins in the metastatic progression of prostate cancer |
| title_full_unstemmed | Changes in extracellular matrix (ECM) and ECM-associated proteins in the metastatic progression of prostate cancer |
| title_short | Changes in extracellular matrix (ECM) and ECM-associated proteins in the metastatic progression of prostate cancer |
| title_sort | changes in extracellular matrix ecm and ecm associated proteins in the metastatic progression of prostate cancer |
| url | http://www.rbej.com/content/2/1/2 |
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