Doxorubicin hydrochloride and L-arginine co-loaded nanovesicle for drug resistance reversal stimulated by near-infrared light
Drug resistance is accountable for the inadequate outcome of chemotherapy in clinics. The newly emerging role of nitric oxide (NO) to conquer drug resistance has been recognized as a potential strategy. However, it remains a great challenge to realize targeted delivery as well as accurate release of...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Asian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1818087622001039 |
| _version_ | 1797980793573736448 |
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| author | Linping Jiang Kesi Wang Liyan Qiu |
| author_facet | Linping Jiang Kesi Wang Liyan Qiu |
| author_sort | Linping Jiang |
| collection | DOAJ |
| description | Drug resistance is accountable for the inadequate outcome of chemotherapy in clinics. The newly emerging role of nitric oxide (NO) to conquer drug resistance has been recognized as a potential strategy. However, it remains a great challenge to realize targeted delivery as well as accurate release of NO at desired sites. Herein, we developed a PEGylated indocyanine green (mPEG-ICG) integrated nanovesicle system (PIDA) to simultaneously load doxorubicin hydrochloride (DOX⋅HCl) and the NO donor L-arginine (L-Arg), which can produce NO triggered by NIR light irradiation and exert multimodal therapy to sensitize drug-resistant cancers. Upon 808 nm irradiation, the NO released from PIDA led to a decrease in mitochondrial membrane potential, an increase in ROS and significant ATP depletion in K562/ADR cells, thus inhibiting cell growth and resolving the problem of drug resistance. Consequently, the in vivo experiment on K562/ADR-bearing nude mice indicated that PIDA nanovesicles achieved significant anticancer efficacy with a tumor inhibition rate of 80.8%. Above all, PIDA nanovesicles offer guidance for designing nanoplatforms for drug-resistant cancer treatment. |
| first_indexed | 2024-04-11T06:00:35Z |
| format | Article |
| id | doaj.art-1eceeb444ce64c31b3be35ef11e1aa70 |
| institution | Directory Open Access Journal |
| issn | 1818-0876 |
| language | English |
| last_indexed | 2024-04-11T06:00:35Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-1eceeb444ce64c31b3be35ef11e1aa702022-12-22T04:41:42ZengElsevierAsian Journal of Pharmaceutical Sciences1818-08762022-11-01176924937Doxorubicin hydrochloride and L-arginine co-loaded nanovesicle for drug resistance reversal stimulated by near-infrared lightLinping Jiang0Kesi Wang1Liyan Qiu2Ministry of Educational (MOE) Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, ChinaMinistry of Educational (MOE) Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, ChinaCorresponding author.; Ministry of Educational (MOE) Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, ChinaDrug resistance is accountable for the inadequate outcome of chemotherapy in clinics. The newly emerging role of nitric oxide (NO) to conquer drug resistance has been recognized as a potential strategy. However, it remains a great challenge to realize targeted delivery as well as accurate release of NO at desired sites. Herein, we developed a PEGylated indocyanine green (mPEG-ICG) integrated nanovesicle system (PIDA) to simultaneously load doxorubicin hydrochloride (DOX⋅HCl) and the NO donor L-arginine (L-Arg), which can produce NO triggered by NIR light irradiation and exert multimodal therapy to sensitize drug-resistant cancers. Upon 808 nm irradiation, the NO released from PIDA led to a decrease in mitochondrial membrane potential, an increase in ROS and significant ATP depletion in K562/ADR cells, thus inhibiting cell growth and resolving the problem of drug resistance. Consequently, the in vivo experiment on K562/ADR-bearing nude mice indicated that PIDA nanovesicles achieved significant anticancer efficacy with a tumor inhibition rate of 80.8%. Above all, PIDA nanovesicles offer guidance for designing nanoplatforms for drug-resistant cancer treatment.http://www.sciencedirect.com/science/article/pii/S1818087622001039Nitric oxideL-arginineDoxorubicinIndocyanine greenDrug resistanceNanovesicle |
| spellingShingle | Linping Jiang Kesi Wang Liyan Qiu Doxorubicin hydrochloride and L-arginine co-loaded nanovesicle for drug resistance reversal stimulated by near-infrared light Asian Journal of Pharmaceutical Sciences Nitric oxide L-arginine Doxorubicin Indocyanine green Drug resistance Nanovesicle |
| title | Doxorubicin hydrochloride and L-arginine co-loaded nanovesicle for drug resistance reversal stimulated by near-infrared light |
| title_full | Doxorubicin hydrochloride and L-arginine co-loaded nanovesicle for drug resistance reversal stimulated by near-infrared light |
| title_fullStr | Doxorubicin hydrochloride and L-arginine co-loaded nanovesicle for drug resistance reversal stimulated by near-infrared light |
| title_full_unstemmed | Doxorubicin hydrochloride and L-arginine co-loaded nanovesicle for drug resistance reversal stimulated by near-infrared light |
| title_short | Doxorubicin hydrochloride and L-arginine co-loaded nanovesicle for drug resistance reversal stimulated by near-infrared light |
| title_sort | doxorubicin hydrochloride and l arginine co loaded nanovesicle for drug resistance reversal stimulated by near infrared light |
| topic | Nitric oxide L-arginine Doxorubicin Indocyanine green Drug resistance Nanovesicle |
| url | http://www.sciencedirect.com/science/article/pii/S1818087622001039 |
| work_keys_str_mv | AT linpingjiang doxorubicinhydrochlorideandlargininecoloadednanovesiclefordrugresistancereversalstimulatedbynearinfraredlight AT kesiwang doxorubicinhydrochlorideandlargininecoloadednanovesiclefordrugresistancereversalstimulatedbynearinfraredlight AT liyanqiu doxorubicinhydrochlorideandlargininecoloadednanovesiclefordrugresistancereversalstimulatedbynearinfraredlight |