Advanced lung cancer inflammation index is associated with long-term cardiovascular death in hypertensive patients: national health and nutrition examination study, 1999–2018
Background: Hypertension is one of the main causes of cardiovascular death. Inflammation was considered influential factors of cardiovascular (CVD) death in patients with hypertension. Advanced lung cancer inflammation index (ALI) is an index to assess inflammation, few studies have investigated the...
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| Format: | Article |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1074672/full |
| _version_ | 1797834717084516352 |
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| author | Jiabin Tu Bo Wu Jiaming Xiu Jiayi Deng Shuqiong Lin Jin Lu Yanfang Yan Pei Yu Jinlong Zhu Kaihong Chen Shan Ding Liling Chen |
| author_facet | Jiabin Tu Bo Wu Jiaming Xiu Jiayi Deng Shuqiong Lin Jin Lu Yanfang Yan Pei Yu Jinlong Zhu Kaihong Chen Shan Ding Liling Chen |
| author_sort | Jiabin Tu |
| collection | DOAJ |
| description | Background: Hypertension is one of the main causes of cardiovascular death. Inflammation was considered influential factors of cardiovascular (CVD) death in patients with hypertension. Advanced lung cancer inflammation index (ALI) is an index to assess inflammation, few studies have investigated the relationship between advanced lung cancer inflammation index and cardiovascular death in hypertensive patients.Objective: The aim of this study was to investigate the association between advanced lung cancer inflammation index and long-term cardiovascular death in hypertensive patients.Method: Data from the National Health and Nutrition Examination Survey (NHANES) 1999–2018 with mortality follow-up through 31 December 2019 were analyzed. Advanced lung cancer inflammation index was calculated as BMI (kg/㎡) × serum albumin level (g/dL)/neutrophil to lymphocyte ratio (NLR). A total of 20,517 participants were evaluated. Patients were divided into three groups based on tertiles of advanced lung cancer inflammation index as follows: T1 (n = 6,839), T2 (n = 6,839), and T3 (n = 6,839) groups. The relationship between advanced lung cancer inflammation index and long-term cardiovascular death was assessed by survival curves and Cox regression analysis based on the NHANES recommended weights.Results: The median advanced lung cancer inflammation index value in this study was 61.9 [44.4, 84.6]. After full adjustment, the T2 group (hazard ratio [HR]: 0.59, 95% confidence interval [CI]: 0.50–0.69; p < 0.001) and T3 group (HR: 0.48, 95% CI: 0.39–0.58; p < 0.001) were found to have a significantly lower risk of cardiovascular death compared to the T1 group.Conclusion: High levels of advanced lung cancer inflammation index were associated with reduced risk of cardiovascular death in hypertensive patients. |
| first_indexed | 2024-04-09T14:42:00Z |
| format | Article |
| id | doaj.art-1ecfbc8f3df4498b9a69d62caa8e790d |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-09T14:42:00Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-1ecfbc8f3df4498b9a69d62caa8e790d2023-05-03T05:18:33ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-05-011410.3389/fphys.2023.10746721074672Advanced lung cancer inflammation index is associated with long-term cardiovascular death in hypertensive patients: national health and nutrition examination study, 1999–2018Jiabin Tu0Bo Wu1Jiaming Xiu2Jiayi Deng3Shuqiong Lin4Jin Lu5Yanfang Yan6Pei Yu7Jinlong Zhu8Kaihong Chen9Shan Ding10Liling Chen11Longyan First Affiliated Hospital of Fujian Medical University, Longyan, ChinaLongyan First Affiliated Hospital of Fujian Medical University, Longyan, ChinaLongyan First Affiliated Hospital of Fujian Medical University, Longyan, ChinaLongyan First Affiliated Hospital of Fujian Medical University, Longyan, ChinaZhangzhou Affiliated Hospital to Fujian Medical University, Zhangzhou, ChinaLongyan First Affiliated Hospital of Fujian Medical University, Longyan, ChinaLongyan First Affiliated Hospital of Fujian Medical University, Longyan, ChinaLongyan First Affiliated Hospital of Fujian Medical University, Longyan, ChinaLongyan First Affiliated Hospital of Fujian Medical University, Longyan, ChinaLongyan First Affiliated Hospital of Fujian Medical University, Longyan, ChinaZhongshan Hospital (Xiamen), Fudan University, Xiamen, ChinaLongyan First Affiliated Hospital of Fujian Medical University, Longyan, ChinaBackground: Hypertension is one of the main causes of cardiovascular death. Inflammation was considered influential factors of cardiovascular (CVD) death in patients with hypertension. Advanced lung cancer inflammation index (ALI) is an index to assess inflammation, few studies have investigated the relationship between advanced lung cancer inflammation index and cardiovascular death in hypertensive patients.Objective: The aim of this study was to investigate the association between advanced lung cancer inflammation index and long-term cardiovascular death in hypertensive patients.Method: Data from the National Health and Nutrition Examination Survey (NHANES) 1999–2018 with mortality follow-up through 31 December 2019 were analyzed. Advanced lung cancer inflammation index was calculated as BMI (kg/㎡) × serum albumin level (g/dL)/neutrophil to lymphocyte ratio (NLR). A total of 20,517 participants were evaluated. Patients were divided into three groups based on tertiles of advanced lung cancer inflammation index as follows: T1 (n = 6,839), T2 (n = 6,839), and T3 (n = 6,839) groups. The relationship between advanced lung cancer inflammation index and long-term cardiovascular death was assessed by survival curves and Cox regression analysis based on the NHANES recommended weights.Results: The median advanced lung cancer inflammation index value in this study was 61.9 [44.4, 84.6]. After full adjustment, the T2 group (hazard ratio [HR]: 0.59, 95% confidence interval [CI]: 0.50–0.69; p < 0.001) and T3 group (HR: 0.48, 95% CI: 0.39–0.58; p < 0.001) were found to have a significantly lower risk of cardiovascular death compared to the T1 group.Conclusion: High levels of advanced lung cancer inflammation index were associated with reduced risk of cardiovascular death in hypertensive patients.https://www.frontiersin.org/articles/10.3389/fphys.2023.1074672/fullhypertensioninflammationcardiovascular deathadvanced lung cancer inflammation indexNHANES |
| spellingShingle | Jiabin Tu Bo Wu Jiaming Xiu Jiayi Deng Shuqiong Lin Jin Lu Yanfang Yan Pei Yu Jinlong Zhu Kaihong Chen Shan Ding Liling Chen Advanced lung cancer inflammation index is associated with long-term cardiovascular death in hypertensive patients: national health and nutrition examination study, 1999–2018 Frontiers in Physiology hypertension inflammation cardiovascular death advanced lung cancer inflammation index NHANES |
| title | Advanced lung cancer inflammation index is associated with long-term cardiovascular death in hypertensive patients: national health and nutrition examination study, 1999–2018 |
| title_full | Advanced lung cancer inflammation index is associated with long-term cardiovascular death in hypertensive patients: national health and nutrition examination study, 1999–2018 |
| title_fullStr | Advanced lung cancer inflammation index is associated with long-term cardiovascular death in hypertensive patients: national health and nutrition examination study, 1999–2018 |
| title_full_unstemmed | Advanced lung cancer inflammation index is associated with long-term cardiovascular death in hypertensive patients: national health and nutrition examination study, 1999–2018 |
| title_short | Advanced lung cancer inflammation index is associated with long-term cardiovascular death in hypertensive patients: national health and nutrition examination study, 1999–2018 |
| title_sort | advanced lung cancer inflammation index is associated with long term cardiovascular death in hypertensive patients national health and nutrition examination study 1999 2018 |
| topic | hypertension inflammation cardiovascular death advanced lung cancer inflammation index NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1074672/full |
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