Recent progress in N6-methyladenosine modification in ocular surface diseases
N6-methyladenosine (m6A) modification is a reversible process promoted by “writers”, inhibited by “erasers”, and processed by “readers”. During the last decade, increasing emphasis has been placed on the underlying roles of m6A modification owing to their great importance in biological significance....
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2023-04-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://ies.ijo.cn/en_publish/2023/4/20230420.pdf |
| _version_ | 1797853433473007616 |
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| author | Wei Wang Jun Zou |
| author_facet | Wei Wang Jun Zou |
| author_sort | Wei Wang |
| collection | DOAJ |
| description | N6-methyladenosine (m6A) modification is a reversible process promoted by “writers”, inhibited by “erasers”, and processed by “readers”. During the last decade, increasing emphasis has been placed on the underlying roles of m6A modification owing to their great importance in biological significance. The abnormal regulation of m6A modification will lead to aberrant cellular behavior and various diseases. Recently, studies have demonstrated that m6A modification is closely associated with the genesis and progression of ocular surface diseases (OSDs). This review focus on the role of m6A modification and research progress in OSDs including fungal keratitis, herpes simplex keratitis, immune-related keratoconjunctival diseases, pterygium, ocular chemical burns, and Graves' ophthalmopathy, which may provide new insights into and prospective applications for OSDs. |
| first_indexed | 2024-04-09T19:50:34Z |
| format | Article |
| id | doaj.art-1ed108975bf049eda7363bb37e72ce08 |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-04-09T19:50:34Z |
| publishDate | 2023-04-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-1ed108975bf049eda7363bb37e72ce082023-04-03T06:59:56ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982023-04-0116464565110.18240/ijo.2023.04.2020230420Recent progress in N6-methyladenosine modification in ocular surface diseasesWei Wang0Jun Zou1Jun Zou. Department of Ophthalmology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China. zoujun70@126.comDepartment of Ophthalmology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaN6-methyladenosine (m6A) modification is a reversible process promoted by “writers”, inhibited by “erasers”, and processed by “readers”. During the last decade, increasing emphasis has been placed on the underlying roles of m6A modification owing to their great importance in biological significance. The abnormal regulation of m6A modification will lead to aberrant cellular behavior and various diseases. Recently, studies have demonstrated that m6A modification is closely associated with the genesis and progression of ocular surface diseases (OSDs). This review focus on the role of m6A modification and research progress in OSDs including fungal keratitis, herpes simplex keratitis, immune-related keratoconjunctival diseases, pterygium, ocular chemical burns, and Graves' ophthalmopathy, which may provide new insights into and prospective applications for OSDs.http://ies.ijo.cn/en_publish/2023/4/20230420.pdfn6-methyladenosinem6a modificationepigeneticsocular surface diseases |
| spellingShingle | Wei Wang Jun Zou Recent progress in N6-methyladenosine modification in ocular surface diseases International Journal of Ophthalmology n6-methyladenosine m6a modification epigenetics ocular surface diseases |
| title | Recent progress in N6-methyladenosine modification in ocular surface diseases |
| title_full | Recent progress in N6-methyladenosine modification in ocular surface diseases |
| title_fullStr | Recent progress in N6-methyladenosine modification in ocular surface diseases |
| title_full_unstemmed | Recent progress in N6-methyladenosine modification in ocular surface diseases |
| title_short | Recent progress in N6-methyladenosine modification in ocular surface diseases |
| title_sort | recent progress in n6 methyladenosine modification in ocular surface diseases |
| topic | n6-methyladenosine m6a modification epigenetics ocular surface diseases |
| url | http://ies.ijo.cn/en_publish/2023/4/20230420.pdf |
| work_keys_str_mv | AT weiwang recentprogressinn6methyladenosinemodificationinocularsurfacediseases AT junzou recentprogressinn6methyladenosinemodificationinocularsurfacediseases |