Blood Adipokines/Cytokines in Young People with Chronic Bronchitis and Abdominal Obesity
The pathogenesis of the development of chronic lung diseases assumes the participation of systemic inflammation factors, as well as hormone-like substances produced by adipose tissue. The aim of this study was to evaluate the associations of certain adipokines/cytokines and chronic bronchitis agains...
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MDPI AG
2022-10-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/10/1502 |
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| author | Alena Dmitrievna Khudiakova Yana Vladimirovna Polonskaya Victoria Sergeevna Shramko Lilia Valeryevna Shcherbakova Evgeniia Vitalievna Striukova Elena Vladimirovna Kashtanova Yulia Igorevna Ragino |
| author_facet | Alena Dmitrievna Khudiakova Yana Vladimirovna Polonskaya Victoria Sergeevna Shramko Lilia Valeryevna Shcherbakova Evgeniia Vitalievna Striukova Elena Vladimirovna Kashtanova Yulia Igorevna Ragino |
| author_sort | Alena Dmitrievna Khudiakova |
| collection | DOAJ |
| description | The pathogenesis of the development of chronic lung diseases assumes the participation of systemic inflammation factors, as well as hormone-like substances produced by adipose tissue. The aim of this study was to evaluate the associations of certain adipokines/cytokines and chronic bronchitis against the background of abdominal obesity in young people. The study included 1415 people aged 25−44. In total, 115 people were selected by the random numbers method, who were divided into two subgroups: those with chronic bronchitis and abdominal obesity and those with chronic bronchitis without abdominal obesity. A control group of patients with comparable gender and age was also selected. In the group of patients with chronic bronchitis, adiponectin, TNFa and GIP levels were 1.4 times higher. The levels of C-peptide, MCP-1 and PP in the group of chronic bronchitis were 1.3 times higher compared to the control. Adipsin, lipocalin-2, IL-6 and resistin were significantly higher in the group with chronic bronchitis. Glucagon, amylin and ghrelin were 2.2, 2.3 and 3.2 times lower, respectively, in the group of patients with chronic bronchitis. Against the background of abdominal obesity, the probability of having chronic bronchitis increased with an increase in the level of lipocalin-2 and GIP and TNFa. |
| first_indexed | 2024-03-09T20:36:37Z |
| format | Article |
| id | doaj.art-1ed2aeeb151345aca850fff5fe6af6f7 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T20:36:37Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-1ed2aeeb151345aca850fff5fe6af6f72023-11-23T23:09:41ZengMDPI AGBiomolecules2218-273X2022-10-011210150210.3390/biom12101502Blood Adipokines/Cytokines in Young People with Chronic Bronchitis and Abdominal ObesityAlena Dmitrievna Khudiakova0Yana Vladimirovna Polonskaya1Victoria Sergeevna Shramko2Lilia Valeryevna Shcherbakova3Evgeniia Vitalievna Striukova4Elena Vladimirovna Kashtanova5Yulia Igorevna Ragino6Research Institute of Internal and Preventive Medicine—Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, B. Bogatkova str., 175/1, Novosibirsk 630089, RussiaResearch Institute of Internal and Preventive Medicine—Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, B. Bogatkova str., 175/1, Novosibirsk 630089, RussiaResearch Institute of Internal and Preventive Medicine—Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, B. Bogatkova str., 175/1, Novosibirsk 630089, RussiaResearch Institute of Internal and Preventive Medicine—Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, B. Bogatkova str., 175/1, Novosibirsk 630089, RussiaResearch Institute of Internal and Preventive Medicine—Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, B. Bogatkova str., 175/1, Novosibirsk 630089, RussiaResearch Institute of Internal and Preventive Medicine—Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, B. Bogatkova str., 175/1, Novosibirsk 630089, RussiaResearch Institute of Internal and Preventive Medicine—Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, B. Bogatkova str., 175/1, Novosibirsk 630089, RussiaThe pathogenesis of the development of chronic lung diseases assumes the participation of systemic inflammation factors, as well as hormone-like substances produced by adipose tissue. The aim of this study was to evaluate the associations of certain adipokines/cytokines and chronic bronchitis against the background of abdominal obesity in young people. The study included 1415 people aged 25−44. In total, 115 people were selected by the random numbers method, who were divided into two subgroups: those with chronic bronchitis and abdominal obesity and those with chronic bronchitis without abdominal obesity. A control group of patients with comparable gender and age was also selected. In the group of patients with chronic bronchitis, adiponectin, TNFa and GIP levels were 1.4 times higher. The levels of C-peptide, MCP-1 and PP in the group of chronic bronchitis were 1.3 times higher compared to the control. Adipsin, lipocalin-2, IL-6 and resistin were significantly higher in the group with chronic bronchitis. Glucagon, amylin and ghrelin were 2.2, 2.3 and 3.2 times lower, respectively, in the group of patients with chronic bronchitis. Against the background of abdominal obesity, the probability of having chronic bronchitis increased with an increase in the level of lipocalin-2 and GIP and TNFa.https://www.mdpi.com/2218-273X/12/10/1502chronic bronchitisabdominal obesitypopulationadipokinescytokines |
| spellingShingle | Alena Dmitrievna Khudiakova Yana Vladimirovna Polonskaya Victoria Sergeevna Shramko Lilia Valeryevna Shcherbakova Evgeniia Vitalievna Striukova Elena Vladimirovna Kashtanova Yulia Igorevna Ragino Blood Adipokines/Cytokines in Young People with Chronic Bronchitis and Abdominal Obesity Biomolecules chronic bronchitis abdominal obesity population adipokines cytokines |
| title | Blood Adipokines/Cytokines in Young People with Chronic Bronchitis and Abdominal Obesity |
| title_full | Blood Adipokines/Cytokines in Young People with Chronic Bronchitis and Abdominal Obesity |
| title_fullStr | Blood Adipokines/Cytokines in Young People with Chronic Bronchitis and Abdominal Obesity |
| title_full_unstemmed | Blood Adipokines/Cytokines in Young People with Chronic Bronchitis and Abdominal Obesity |
| title_short | Blood Adipokines/Cytokines in Young People with Chronic Bronchitis and Abdominal Obesity |
| title_sort | blood adipokines cytokines in young people with chronic bronchitis and abdominal obesity |
| topic | chronic bronchitis abdominal obesity population adipokines cytokines |
| url | https://www.mdpi.com/2218-273X/12/10/1502 |
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