The Feasibility of Liver Biopsy for Undefined Nodules in Patients under Surveillance for Hepatocellular Carcinoma: Is Biopsy Really a Useful Tool?
<b>Background</b>: The aim of the present study is to determine the feasibility of biopsy for atypical liver nodules in patients under surveillance for hepatocellular carcinoma (HCC), assessing which factors influence the decision to perform it. <b>Methods</b>: A total of 128...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/15/4399 |
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| author | Matteo Renzulli Anna Pecorelli Nicolò Brandi Stefano Brocchi Francesco Tovoli Alessandro Granito Gianpaolo Carrafiello Anna Maria Ierardi Rita Golfieri |
| author_facet | Matteo Renzulli Anna Pecorelli Nicolò Brandi Stefano Brocchi Francesco Tovoli Alessandro Granito Gianpaolo Carrafiello Anna Maria Ierardi Rita Golfieri |
| author_sort | Matteo Renzulli |
| collection | DOAJ |
| description | <b>Background</b>: The aim of the present study is to determine the feasibility of biopsy for atypical liver nodules in patients under surveillance for hepatocellular carcinoma (HCC), assessing which factors influence the decision to perform it. <b>Methods</b>: A total of 128 atypical liver nodules in 108 patients under surveillance for HCC, who underwent CT between September 2018 and September 2019, were included. All the images were saved digitally (on CD-ROM) and the two most representative images in the arterial and delayed phases were selected for each lesion and inserted into a digital atlas (on PDF). Two experienced radiologists (Readers 1 and 2) reviewed both the CD-ROM and the PDF to define the feasibility of biopsy in both scenarios, specifying the reasons for the unfeasibility of biopsy. The intra-observer variability and inter-observer variability were assessed. <b>Results</b>: When reviewing the PDF, 76 (59.4%) and 68 (53.1%) nodules were deemed unfeasible for biopsy by the less experienced radiologist (Reader 1) and the more experienced radiologist (Reader 2), respectively (<i>p</i> = 0.604). When reviewing the entire CT study, both percentages decreased slightly (Reader 1 = 70/128 (54.7%); Reader 2 = 61/128 (47.6%); <i>p</i> = 0.591). The intra-reader agreement on the PDF was substantial (k = 0.648 (95% CI = 0.513–0.783)). The inter-reader agreement on the PDF was slight (k = 0.185 (95% CI = 0.021–0.348)) and moderate on the entire CT study (k = 0.424 (95% CI = 0.269–0.579)). When assessing the PDF, the nodule size (10–20 mm) and location in segments six and eight were negatively and positively associated with the feasibility of liver biopsy, respectively. When assessing the CD-ROM, only the nodule dimension was associated with the unfeasibility of liver biopsy. <b>Conclusions</b>: The unfeasibility of liver biopsy is mainly due to the small size of the lesions and their location. |
| first_indexed | 2024-03-09T12:27:26Z |
| format | Article |
| id | doaj.art-1ed576e28f564ab7aac3155d9c6d4cb1 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T12:27:26Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-1ed576e28f564ab7aac3155d9c6d4cb12023-11-30T22:32:54ZengMDPI AGJournal of Clinical Medicine2077-03832022-07-011115439910.3390/jcm11154399The Feasibility of Liver Biopsy for Undefined Nodules in Patients under Surveillance for Hepatocellular Carcinoma: Is Biopsy Really a Useful Tool?Matteo Renzulli0Anna Pecorelli1Nicolò Brandi2Stefano Brocchi3Francesco Tovoli4Alessandro Granito5Gianpaolo Carrafiello6Anna Maria Ierardi7Rita Golfieri8Department of Radiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni 15, 40138 Bologna, ItalyDepartment of Radiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni 15, 40138 Bologna, ItalyDepartment of Radiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni 15, 40138 Bologna, ItalyDepartment of Radiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni 15, 40138 Bologna, ItalyDivision of Internal Medicine, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyDivision of Internal Medicine, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyDiagnostic and Interventional Radiology Department, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, 20021 Milan, ItalyDiagnostic and Interventional Radiology Department, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, 20021 Milan, ItalyDepartment of Radiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni 15, 40138 Bologna, Italy<b>Background</b>: The aim of the present study is to determine the feasibility of biopsy for atypical liver nodules in patients under surveillance for hepatocellular carcinoma (HCC), assessing which factors influence the decision to perform it. <b>Methods</b>: A total of 128 atypical liver nodules in 108 patients under surveillance for HCC, who underwent CT between September 2018 and September 2019, were included. All the images were saved digitally (on CD-ROM) and the two most representative images in the arterial and delayed phases were selected for each lesion and inserted into a digital atlas (on PDF). Two experienced radiologists (Readers 1 and 2) reviewed both the CD-ROM and the PDF to define the feasibility of biopsy in both scenarios, specifying the reasons for the unfeasibility of biopsy. The intra-observer variability and inter-observer variability were assessed. <b>Results</b>: When reviewing the PDF, 76 (59.4%) and 68 (53.1%) nodules were deemed unfeasible for biopsy by the less experienced radiologist (Reader 1) and the more experienced radiologist (Reader 2), respectively (<i>p</i> = 0.604). When reviewing the entire CT study, both percentages decreased slightly (Reader 1 = 70/128 (54.7%); Reader 2 = 61/128 (47.6%); <i>p</i> = 0.591). The intra-reader agreement on the PDF was substantial (k = 0.648 (95% CI = 0.513–0.783)). The inter-reader agreement on the PDF was slight (k = 0.185 (95% CI = 0.021–0.348)) and moderate on the entire CT study (k = 0.424 (95% CI = 0.269–0.579)). When assessing the PDF, the nodule size (10–20 mm) and location in segments six and eight were negatively and positively associated with the feasibility of liver biopsy, respectively. When assessing the CD-ROM, only the nodule dimension was associated with the unfeasibility of liver biopsy. <b>Conclusions</b>: The unfeasibility of liver biopsy is mainly due to the small size of the lesions and their location.https://www.mdpi.com/2077-0383/11/15/4399hepatocellular carcinomaliver biopsyfeasibilityliver imagingmultidisciplinary meeting |
| spellingShingle | Matteo Renzulli Anna Pecorelli Nicolò Brandi Stefano Brocchi Francesco Tovoli Alessandro Granito Gianpaolo Carrafiello Anna Maria Ierardi Rita Golfieri The Feasibility of Liver Biopsy for Undefined Nodules in Patients under Surveillance for Hepatocellular Carcinoma: Is Biopsy Really a Useful Tool? Journal of Clinical Medicine hepatocellular carcinoma liver biopsy feasibility liver imaging multidisciplinary meeting |
| title | The Feasibility of Liver Biopsy for Undefined Nodules in Patients under Surveillance for Hepatocellular Carcinoma: Is Biopsy Really a Useful Tool? |
| title_full | The Feasibility of Liver Biopsy for Undefined Nodules in Patients under Surveillance for Hepatocellular Carcinoma: Is Biopsy Really a Useful Tool? |
| title_fullStr | The Feasibility of Liver Biopsy for Undefined Nodules in Patients under Surveillance for Hepatocellular Carcinoma: Is Biopsy Really a Useful Tool? |
| title_full_unstemmed | The Feasibility of Liver Biopsy for Undefined Nodules in Patients under Surveillance for Hepatocellular Carcinoma: Is Biopsy Really a Useful Tool? |
| title_short | The Feasibility of Liver Biopsy for Undefined Nodules in Patients under Surveillance for Hepatocellular Carcinoma: Is Biopsy Really a Useful Tool? |
| title_sort | feasibility of liver biopsy for undefined nodules in patients under surveillance for hepatocellular carcinoma is biopsy really a useful tool |
| topic | hepatocellular carcinoma liver biopsy feasibility liver imaging multidisciplinary meeting |
| url | https://www.mdpi.com/2077-0383/11/15/4399 |
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