Structural Basis for Epitopes in the gp120 Cluster A Region that Invokes Potent Effector Cell Activity
While a number of therapeutic options to control the progression of human immunodeficiency virus (HIV-1) now exist, a broadly effective preventive vaccine is still not available. Through detailed structural analysis of antibodies able to induce potent effector cell activity, a number of Env epitopes...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-01-01
|
| Series: | Viruses |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1999-4915/11/1/69 |
| _version_ | 1811310709119647744 |
|---|---|
| author | William D. Tolbert Rebekah T. Sherburn Verna Van Marzena Pazgier |
| author_facet | William D. Tolbert Rebekah T. Sherburn Verna Van Marzena Pazgier |
| author_sort | William D. Tolbert |
| collection | DOAJ |
| description | While a number of therapeutic options to control the progression of human immunodeficiency virus (HIV-1) now exist, a broadly effective preventive vaccine is still not available. Through detailed structural analysis of antibodies able to induce potent effector cell activity, a number of Env epitopes have been identified which have the potential to be considered vaccine candidates. These antibodies mainly target the gp120 Cluster A region which is only exposed upon viral binding to the target cell with epitopes becoming available for antibody binding during viral entry and fusion and, therefore, after the effective window for neutralizing antibody activity. This review will discuss recent advances in the structural characterization of these important targets with a special focus on epitopes that are involved in Fc-mediated effector function without direct viral neutralizing activities. |
| first_indexed | 2024-04-13T10:03:43Z |
| format | Article |
| id | doaj.art-1ed7627c20e645748a91956324c92970 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-04-13T10:03:43Z |
| publishDate | 2019-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-1ed7627c20e645748a91956324c929702022-12-22T02:51:10ZengMDPI AGViruses1999-49152019-01-011116910.3390/v11010069v11010069Structural Basis for Epitopes in the gp120 Cluster A Region that Invokes Potent Effector Cell ActivityWilliam D. Tolbert0Rebekah T. Sherburn1Verna Van2Marzena Pazgier3Infectious Diseases Division, Department of Medicine of Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USAInfectious Diseases Division, Department of Medicine of Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USADepartment of Biochemistry and Molecular Biology of University of Maryland School of Medicine, Baltimore, MD 21201, USAInfectious Diseases Division, Department of Medicine of Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USAWhile a number of therapeutic options to control the progression of human immunodeficiency virus (HIV-1) now exist, a broadly effective preventive vaccine is still not available. Through detailed structural analysis of antibodies able to induce potent effector cell activity, a number of Env epitopes have been identified which have the potential to be considered vaccine candidates. These antibodies mainly target the gp120 Cluster A region which is only exposed upon viral binding to the target cell with epitopes becoming available for antibody binding during viral entry and fusion and, therefore, after the effective window for neutralizing antibody activity. This review will discuss recent advances in the structural characterization of these important targets with a special focus on epitopes that are involved in Fc-mediated effector function without direct viral neutralizing activities.http://www.mdpi.com/1999-4915/11/1/69HIVstructureADCCvaccineA32C11 |
| spellingShingle | William D. Tolbert Rebekah T. Sherburn Verna Van Marzena Pazgier Structural Basis for Epitopes in the gp120 Cluster A Region that Invokes Potent Effector Cell Activity Viruses HIV structure ADCC vaccine A32 C11 |
| title | Structural Basis for Epitopes in the gp120 Cluster A Region that Invokes Potent Effector Cell Activity |
| title_full | Structural Basis for Epitopes in the gp120 Cluster A Region that Invokes Potent Effector Cell Activity |
| title_fullStr | Structural Basis for Epitopes in the gp120 Cluster A Region that Invokes Potent Effector Cell Activity |
| title_full_unstemmed | Structural Basis for Epitopes in the gp120 Cluster A Region that Invokes Potent Effector Cell Activity |
| title_short | Structural Basis for Epitopes in the gp120 Cluster A Region that Invokes Potent Effector Cell Activity |
| title_sort | structural basis for epitopes in the gp120 cluster a region that invokes potent effector cell activity |
| topic | HIV structure ADCC vaccine A32 C11 |
| url | http://www.mdpi.com/1999-4915/11/1/69 |
| work_keys_str_mv | AT williamdtolbert structuralbasisforepitopesinthegp120clusteraregionthatinvokespotenteffectorcellactivity AT rebekahtsherburn structuralbasisforepitopesinthegp120clusteraregionthatinvokespotenteffectorcellactivity AT vernavan structuralbasisforepitopesinthegp120clusteraregionthatinvokespotenteffectorcellactivity AT marzenapazgier structuralbasisforepitopesinthegp120clusteraregionthatinvokespotenteffectorcellactivity |