Research progress on the role of Müller glial cells in retinal nerve injury
Müller glial cells(MGCs)are the major type of glial cells in the retina which radiating across the entire retina. MGCs make a close contact with retinal neurons, interact, and contribute to retinal homeostasis. After retinal nerve injury, MGCs respond to retinal injury in a variety of regulatory way...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2022-09-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2022/9/202209013.pdf |
| _version_ | 1818037083536621568 |
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| author | Sha Liu Qin Jiang |
| author_facet | Sha Liu Qin Jiang |
| author_sort | Sha Liu |
| collection | DOAJ |
| description | Müller glial cells(MGCs)are the major type of glial cells in the retina which radiating across the entire retina. MGCs make a close contact with retinal neurons, interact, and contribute to retinal homeostasis. After retinal nerve injury, MGCs respond to retinal injury in a variety of regulatory ways to protect the inner retinal environment changes and damage, producing retinal neuroprotective effects, such as regulating neurotransmitters release, releasing neuroprotective factors and antioxidant factors and reprogramming for endogenous repair. However, persistent pathological stimulation in retina can also exacerbate MGCs' proliferation which participate in neuronal dysfunction or loss. Therefore, a proper understanding of the response of MGCs to pathological stimuli and their protective and damaging effects will have a great impact on revealing mechanisms of retinal nerve damage disease and guiding the treatment of the disease. This article reviews the role of MGCs in retinal nerve injury and repair and provides new strategies for retinal neuroprotection. |
| first_indexed | 2024-12-10T07:21:12Z |
| format | Article |
| id | doaj.art-1ed88c5766d840ae852521902b73c44d |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-12-10T07:21:12Z |
| publishDate | 2022-09-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-1ed88c5766d840ae852521902b73c44d2022-12-22T01:57:48ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232022-09-012291485148910.3980/j.issn.1672-5123.2022.9.13202209013Research progress on the role of Müller glial cells in retinal nerve injurySha Liu0Qin Jiang1The Affiliated Eye Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, ChinaThe Affiliated Eye Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, ChinaMüller glial cells(MGCs)are the major type of glial cells in the retina which radiating across the entire retina. MGCs make a close contact with retinal neurons, interact, and contribute to retinal homeostasis. After retinal nerve injury, MGCs respond to retinal injury in a variety of regulatory ways to protect the inner retinal environment changes and damage, producing retinal neuroprotective effects, such as regulating neurotransmitters release, releasing neuroprotective factors and antioxidant factors and reprogramming for endogenous repair. However, persistent pathological stimulation in retina can also exacerbate MGCs' proliferation which participate in neuronal dysfunction or loss. Therefore, a proper understanding of the response of MGCs to pathological stimuli and their protective and damaging effects will have a great impact on revealing mechanisms of retinal nerve damage disease and guiding the treatment of the disease. This article reviews the role of MGCs in retinal nerve injury and repair and provides new strategies for retinal neuroprotection.http://ies.ijo.cn/cn_publish/2022/9/202209013.pdfmüller glial cellsretinal nerve injuryneuroprotection |
| spellingShingle | Sha Liu Qin Jiang Research progress on the role of Müller glial cells in retinal nerve injury Guoji Yanke Zazhi müller glial cells retinal nerve injury neuroprotection |
| title | Research progress on the role of Müller glial cells in retinal nerve injury |
| title_full | Research progress on the role of Müller glial cells in retinal nerve injury |
| title_fullStr | Research progress on the role of Müller glial cells in retinal nerve injury |
| title_full_unstemmed | Research progress on the role of Müller glial cells in retinal nerve injury |
| title_short | Research progress on the role of Müller glial cells in retinal nerve injury |
| title_sort | research progress on the role of muller glial cells in retinal nerve injury |
| topic | müller glial cells retinal nerve injury neuroprotection |
| url | http://ies.ijo.cn/cn_publish/2022/9/202209013.pdf |
| work_keys_str_mv | AT shaliu researchprogressontheroleofmullerglialcellsinretinalnerveinjury AT qinjiang researchprogressontheroleofmullerglialcellsinretinalnerveinjury |