Sequential analysis as a tool for detection of amikacin ototoxicity in the treatment of multidrug-resistant tuberculosis
ABSTRACT Objective: To investigate early detection of amikacin-induced ototoxicity in a population treated for multidrug-resistant tuberculosis (MDR-TB), by means of three different tests: pure-tone audiometry (PTA); high-frequency audiometry (HFA); and distortion-product otoacoustic emission (DPOA...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Pneumologia e Tisiologia
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| Series: | Jornal Brasileiro de Pneumologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132018000200085&lng=en&tlng=en |
| _version_ | 1819327158667968512 |
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| author | Karla Anacleto de Vasconcelos Silvana Maria Monte Coelho Frota Antonio Ruffino-Netto Afrânio Lineu Kritski |
| author_facet | Karla Anacleto de Vasconcelos Silvana Maria Monte Coelho Frota Antonio Ruffino-Netto Afrânio Lineu Kritski |
| author_sort | Karla Anacleto de Vasconcelos |
| collection | DOAJ |
| description | ABSTRACT Objective: To investigate early detection of amikacin-induced ototoxicity in a population treated for multidrug-resistant tuberculosis (MDR-TB), by means of three different tests: pure-tone audiometry (PTA); high-frequency audiometry (HFA); and distortion-product otoacoustic emission (DPOAE) testing. Methods: This was a longitudinal prospective cohort study involving patients aged 18-69 years with a diagnosis of MDR-TB who had to receive amikacin for six months as part of their antituberculosis drug regimen for the first time. Hearing was assessed before treatment initiation and at two and six months after treatment initiation. Sequential statistics were used to analyze the results. Results: We included 61 patients, but the final population consisted of 10 patients (7 men and 3 women) because of sequential analysis. Comparison of the test results obtained at two and six months after treatment initiation with those obtained at baseline revealed that HFA at two months and PTA at six months detected hearing threshold shifts consistent with ototoxicity. However, DPOAE testing did not detect such shifts. Conclusions: The statistical method used in this study makes it possible to conclude that, over the six-month period, amikacin-associated hearing threshold shifts were detected by HFA and PTA, and that DPOAE testing was not efficient in detecting such shifts. |
| first_indexed | 2024-12-24T13:06:24Z |
| format | Article |
| id | doaj.art-1eda366a71734103ac09fefbdc58b3af |
| institution | Directory Open Access Journal |
| issn | 1806-3756 |
| language | English |
| last_indexed | 2024-12-24T13:06:24Z |
| publisher | Sociedade Brasileira de Pneumologia e Tisiologia |
| record_format | Article |
| series | Jornal Brasileiro de Pneumologia |
| spelling | doaj.art-1eda366a71734103ac09fefbdc58b3af2022-12-21T16:53:59ZengSociedade Brasileira de Pneumologia e TisiologiaJornal Brasileiro de Pneumologia1806-3756442859210.1590/s1806-37562016000000312S1806-37132018000200085Sequential analysis as a tool for detection of amikacin ototoxicity in the treatment of multidrug-resistant tuberculosisKarla Anacleto de VasconcelosSilvana Maria Monte Coelho FrotaAntonio Ruffino-NettoAfrânio Lineu KritskiABSTRACT Objective: To investigate early detection of amikacin-induced ototoxicity in a population treated for multidrug-resistant tuberculosis (MDR-TB), by means of three different tests: pure-tone audiometry (PTA); high-frequency audiometry (HFA); and distortion-product otoacoustic emission (DPOAE) testing. Methods: This was a longitudinal prospective cohort study involving patients aged 18-69 years with a diagnosis of MDR-TB who had to receive amikacin for six months as part of their antituberculosis drug regimen for the first time. Hearing was assessed before treatment initiation and at two and six months after treatment initiation. Sequential statistics were used to analyze the results. Results: We included 61 patients, but the final population consisted of 10 patients (7 men and 3 women) because of sequential analysis. Comparison of the test results obtained at two and six months after treatment initiation with those obtained at baseline revealed that HFA at two months and PTA at six months detected hearing threshold shifts consistent with ototoxicity. However, DPOAE testing did not detect such shifts. Conclusions: The statistical method used in this study makes it possible to conclude that, over the six-month period, amikacin-associated hearing threshold shifts were detected by HFA and PTA, and that DPOAE testing was not efficient in detecting such shifts.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132018000200085&lng=en&tlng=enTuberculosePerda auditivaAminoglicosídeos/toxicidade |
| spellingShingle | Karla Anacleto de Vasconcelos Silvana Maria Monte Coelho Frota Antonio Ruffino-Netto Afrânio Lineu Kritski Sequential analysis as a tool for detection of amikacin ototoxicity in the treatment of multidrug-resistant tuberculosis Jornal Brasileiro de Pneumologia Tuberculose Perda auditiva Aminoglicosídeos/toxicidade |
| title | Sequential analysis as a tool for detection of amikacin ototoxicity in the treatment of multidrug-resistant tuberculosis |
| title_full | Sequential analysis as a tool for detection of amikacin ototoxicity in the treatment of multidrug-resistant tuberculosis |
| title_fullStr | Sequential analysis as a tool for detection of amikacin ototoxicity in the treatment of multidrug-resistant tuberculosis |
| title_full_unstemmed | Sequential analysis as a tool for detection of amikacin ototoxicity in the treatment of multidrug-resistant tuberculosis |
| title_short | Sequential analysis as a tool for detection of amikacin ototoxicity in the treatment of multidrug-resistant tuberculosis |
| title_sort | sequential analysis as a tool for detection of amikacin ototoxicity in the treatment of multidrug resistant tuberculosis |
| topic | Tuberculose Perda auditiva Aminoglicosídeos/toxicidade |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132018000200085&lng=en&tlng=en |
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