The noncoding-RNA landscape in cardiovascular health and disease
The cardiovascular system plays a pivotal role in regulating and maintaining homeostasis in the human body. Therefore any alteration in regulatory networks that orchestrate heart development as well as adaptation to physiological and environmental stress might result in pathological conditions, whic...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2018-03-01
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| Series: | Non-coding RNA Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468054017300483 |
| _version_ | 1797203213044154368 |
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| author | Vittoria Di Mauro Maria Barandalla-Sobrados Daniele Catalucci |
| author_facet | Vittoria Di Mauro Maria Barandalla-Sobrados Daniele Catalucci |
| author_sort | Vittoria Di Mauro |
| collection | DOAJ |
| description | The cardiovascular system plays a pivotal role in regulating and maintaining homeostasis in the human body. Therefore any alteration in regulatory networks that orchestrate heart development as well as adaptation to physiological and environmental stress might result in pathological conditions, which represent the leading cause of death worldwide [1]. The latest advances in genome-wide techniques challenged the “protein-central dogma” with the discovery of the so-called non-coding RNAs (ncRNAs). Despite their lack of protein coding potential, ncRNAs have been largely demonstrated to regulate the majority of biological processes and have also been largely implicated in cardiovascular disorders. This review will first discuss the important mechanistic aspects of some of the classes of ncRNAs such as biogenesis, mechanism of action, as well as their involvement in cardiac diseases. The ncRNA potential uses as therapeutic molecules, with a specific focus on the latest technologies for their in vivo delivery as drug targets, will be described. |
| first_indexed | 2024-04-24T08:15:45Z |
| format | Article |
| id | doaj.art-1edbeb7aa22b4aa78b1106fcf8e29be1 |
| institution | Directory Open Access Journal |
| issn | 2468-0540 |
| language | English |
| last_indexed | 2024-04-24T08:15:45Z |
| publishDate | 2018-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Non-coding RNA Research |
| spelling | doaj.art-1edbeb7aa22b4aa78b1106fcf8e29be12024-04-17T03:53:58ZengKeAi Communications Co., Ltd.Non-coding RNA Research2468-05402018-03-01311219The noncoding-RNA landscape in cardiovascular health and diseaseVittoria Di Mauro0Maria Barandalla-Sobrados1Daniele Catalucci2National Research Council, Institute of Genetics and Biomedical Research, Milan Unit, Milan, Italy; Humanitas Clinical and Research Center, Rozzano, Milan, Italy; Corresponding author. National Research Council, Institute of Genetics and Biomedical Research, Milan Unit, Milan, Italy.National Research Council, Institute of Genetics and Biomedical Research, Milan Unit, Milan, Italy; Humanitas Clinical and Research Center, Rozzano, Milan, ItalyNational Research Council, Institute of Genetics and Biomedical Research, Milan Unit, Milan, Italy; Humanitas Clinical and Research Center, Rozzano, Milan, Italy; Corresponding author. National Research Council, Institute of Genetics and Biomedical Research, Milan Unit, Milan, Italy.The cardiovascular system plays a pivotal role in regulating and maintaining homeostasis in the human body. Therefore any alteration in regulatory networks that orchestrate heart development as well as adaptation to physiological and environmental stress might result in pathological conditions, which represent the leading cause of death worldwide [1]. The latest advances in genome-wide techniques challenged the “protein-central dogma” with the discovery of the so-called non-coding RNAs (ncRNAs). Despite their lack of protein coding potential, ncRNAs have been largely demonstrated to regulate the majority of biological processes and have also been largely implicated in cardiovascular disorders. This review will first discuss the important mechanistic aspects of some of the classes of ncRNAs such as biogenesis, mechanism of action, as well as their involvement in cardiac diseases. The ncRNA potential uses as therapeutic molecules, with a specific focus on the latest technologies for their in vivo delivery as drug targets, will be described.http://www.sciencedirect.com/science/article/pii/S2468054017300483 |
| spellingShingle | Vittoria Di Mauro Maria Barandalla-Sobrados Daniele Catalucci The noncoding-RNA landscape in cardiovascular health and disease Non-coding RNA Research |
| title | The noncoding-RNA landscape in cardiovascular health and disease |
| title_full | The noncoding-RNA landscape in cardiovascular health and disease |
| title_fullStr | The noncoding-RNA landscape in cardiovascular health and disease |
| title_full_unstemmed | The noncoding-RNA landscape in cardiovascular health and disease |
| title_short | The noncoding-RNA landscape in cardiovascular health and disease |
| title_sort | noncoding rna landscape in cardiovascular health and disease |
| url | http://www.sciencedirect.com/science/article/pii/S2468054017300483 |
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