Synthesis and Evaluation of Anti-HIV Activity of Mono- and Di-Substituted Phosphonamidate Conjugates of Tenofovir

Synthesis and Evaluation of Anti-HIV Activity of Mono- and Di-Substituted Phosphonamidate Conjugates of Tenofovir

The activity of nucleoside and nucleotide analogs as antiviral agents requires phosphorylation by endogenous enzymes. Phosphate-substituted analogs have low bioavailability due to the presence of ionizable negatively-charged groups. To circumvent these limitations, several prodrug approaches have be...

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Bibliographic Details
Main Authors: Aaminat Qureshi, Louise A. Ouattara, Naglaa Salem El-Sayed, Amita Verma, Gustavo F. Doncel, Muhammad Iqbal Choudhary, Hina Siddiqui, Keykavous Parang
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Molecules
Subjects:
anti-HIV activity
ester conjugates of TFV
phosphonamidate
tenofovir (TFV)
tenofovir alafenamide (TAF)
Online Access:https://www.mdpi.com/1420-3049/27/14/4447

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