Muscle A-Kinase Anchoring Protein-α is an Injury-Specific Signaling Scaffold Required for Neurotrophic- and Cyclic Adenosine Monophosphate-Mediated Survival

Muscle A-Kinase Anchoring Protein-α is an Injury-Specific Signaling Scaffold Required for Neurotrophic- and Cyclic Adenosine Monophosphate-Mediated Survival

Neurotrophic factor and cAMP-dependent signaling promote the survival and neurite outgrowth of retinal ganglion cells (RGCs) after injury. However, the mechanisms conferring neuroprotection and neuroregeneration downstream to these signals are unclear. We now reveal that the scaffold protein muscle...

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Bibliographic Details
Main Authors: Yan Wang, Evan G. Cameron, Jinliang Li, Travis L. Stiles, Michael D. Kritzer, Rahul Lodhavia, Jonathan Hertz, Tu Nguyen, Michael S. Kapiloff, Jeffrey L. Goldberg
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:EBioMedicine
Subjects:
mAKAP
Retinal ganglion cells
Survival
Axon growth
Optic nerve injury
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415301857

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