New concepts regarding micro/nanopharmaceutical polymer systems with applications in ophthalmology and neurosciences
Particulate systems like micro/nanoparticles have been used as a physical approach to modify the pharmacokinetic and pharmacodynamic properties of various types of drug molecules increasing this way the drug bioavailability and avoiding the toxic level. The major advantages of the particulate system...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
London Academic Publishing
2011-09-01
|
| Series: | Romanian Neurosurgery |
| Subjects: | |
| Online Access: | https://www.journals.lapub.co.uk/index.php/roneurosurgery/article/view/595 |
| _version_ | 1818064323550904320 |
|---|---|
| author | Fotios A. Gardikiotis Catalina A. Peptu Marcel Popa Danut Costin |
| author_facet | Fotios A. Gardikiotis Catalina A. Peptu Marcel Popa Danut Costin |
| author_sort | Fotios A. Gardikiotis |
| collection | DOAJ |
| description | Particulate systems like micro/nanoparticles have been used as a physical approach to modify the pharmacokinetic and pharmacodynamic properties of various types of drug molecules increasing this way the drug bioavailability and avoiding the toxic level. The major advantages of the particulate systems include the protection of the drug entity in the systemic circulation, restriction access of the drug to the chosen sites and delivery of the drug at a controlled and sustained rate to the site of action. Various materials have been used in the formulation of micro/nanoparticles for drug delivery research to increase therapeutic benefit, while minimizing side effects. Each class of materials (metals, lipids, polymers) presents advantages which make them suitable for different classes of applications. This paper focuses mainly on polymer particulate systems due to their large applicability area given by the diversity of the polymers properties. We review various aspects of micro/nanoparticle formulation including preparation, release mechanisms, effect of their characteristics and their applications in the field of ophthalmology and neurosciences. Some of the most interesting applications of polymer micro/nanoparticulates in glaucoma, retinal disorders and optical nerve disorders, respectivelly in neurology and neurosurgery are presented. |
| first_indexed | 2024-12-10T14:34:10Z |
| format | Article |
| id | doaj.art-1ee0d1f27d134d54886c1b13048d2af8 |
| institution | Directory Open Access Journal |
| issn | 1220-8841 2344-4959 |
| language | English |
| last_indexed | 2024-12-10T14:34:10Z |
| publishDate | 2011-09-01 |
| publisher | London Academic Publishing |
| record_format | Article |
| series | Romanian Neurosurgery |
| spelling | doaj.art-1ee0d1f27d134d54886c1b13048d2af82022-12-22T01:44:52ZengLondon Academic PublishingRomanian Neurosurgery1220-88412344-49592011-09-01183New concepts regarding micro/nanopharmaceutical polymer systems with applications in ophthalmology and neurosciencesFotios A. GardikiotisCatalina A. PeptuMarcel PopaDanut CostinParticulate systems like micro/nanoparticles have been used as a physical approach to modify the pharmacokinetic and pharmacodynamic properties of various types of drug molecules increasing this way the drug bioavailability and avoiding the toxic level. The major advantages of the particulate systems include the protection of the drug entity in the systemic circulation, restriction access of the drug to the chosen sites and delivery of the drug at a controlled and sustained rate to the site of action. Various materials have been used in the formulation of micro/nanoparticles for drug delivery research to increase therapeutic benefit, while minimizing side effects. Each class of materials (metals, lipids, polymers) presents advantages which make them suitable for different classes of applications. This paper focuses mainly on polymer particulate systems due to their large applicability area given by the diversity of the polymers properties. We review various aspects of micro/nanoparticle formulation including preparation, release mechanisms, effect of their characteristics and their applications in the field of ophthalmology and neurosciences. Some of the most interesting applications of polymer micro/nanoparticulates in glaucoma, retinal disorders and optical nerve disorders, respectivelly in neurology and neurosurgery are presented.https://www.journals.lapub.co.uk/index.php/roneurosurgery/article/view/595controlled drug deliverymicro/nanoparticlesneuroscienceophthalmology |
| spellingShingle | Fotios A. Gardikiotis Catalina A. Peptu Marcel Popa Danut Costin New concepts regarding micro/nanopharmaceutical polymer systems with applications in ophthalmology and neurosciences Romanian Neurosurgery controlled drug delivery micro/nanoparticles neuroscience ophthalmology |
| title | New concepts regarding micro/nanopharmaceutical polymer systems with applications in ophthalmology and neurosciences |
| title_full | New concepts regarding micro/nanopharmaceutical polymer systems with applications in ophthalmology and neurosciences |
| title_fullStr | New concepts regarding micro/nanopharmaceutical polymer systems with applications in ophthalmology and neurosciences |
| title_full_unstemmed | New concepts regarding micro/nanopharmaceutical polymer systems with applications in ophthalmology and neurosciences |
| title_short | New concepts regarding micro/nanopharmaceutical polymer systems with applications in ophthalmology and neurosciences |
| title_sort | new concepts regarding micro nanopharmaceutical polymer systems with applications in ophthalmology and neurosciences |
| topic | controlled drug delivery micro/nanoparticles neuroscience ophthalmology |
| url | https://www.journals.lapub.co.uk/index.php/roneurosurgery/article/view/595 |
| work_keys_str_mv | AT fotiosagardikiotis newconceptsregardingmicronanopharmaceuticalpolymersystemswithapplicationsinophthalmologyandneurosciences AT catalinaapeptu newconceptsregardingmicronanopharmaceuticalpolymersystemswithapplicationsinophthalmologyandneurosciences AT marcelpopa newconceptsregardingmicronanopharmaceuticalpolymersystemswithapplicationsinophthalmologyandneurosciences AT danutcostin newconceptsregardingmicronanopharmaceuticalpolymersystemswithapplicationsinophthalmologyandneurosciences |