Prevalence of dyslipidemia in adolescents: Comparison between definitions
Introduction: The indiscriminate use of different diagnostic criteria for the definition of dyslipidemia may result in inaccurate interpretations, which could compromise diagnosis and therefore the therapeutic and prophylactic actions to be taken. Objective: To analyze possible differences in preval...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-02-01
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| Series: | Revista Portuguesa de Cardiologia |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0870255115000050 |
| _version_ | 1818313413225349120 |
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| author | Crisieli M. Tomeleri Enio R.V. Ronque Danilo R.P. Silva Crivaldo G. Cardoso Júnior Rômulo A. Fernandes Denilson C. Teixeira Décio S. Barbosa Danielle Venturini Alessandra M. Okino Jair A. Oliveira Edilson S. Cyrino |
| author_facet | Crisieli M. Tomeleri Enio R.V. Ronque Danilo R.P. Silva Crivaldo G. Cardoso Júnior Rômulo A. Fernandes Denilson C. Teixeira Décio S. Barbosa Danielle Venturini Alessandra M. Okino Jair A. Oliveira Edilson S. Cyrino |
| author_sort | Crisieli M. Tomeleri |
| collection | DOAJ |
| description | Introduction: The indiscriminate use of different diagnostic criteria for the definition of dyslipidemia may result in inaccurate interpretations, which could compromise diagnosis and therefore the therapeutic and prophylactic actions to be taken. Objective: To analyze possible differences in prevalence rates of dyslipidemia in adolescents based on three diagnostic definitions. Methods: A cross-sectional study was conducted of a representative sample of Brazilian adolescents between 11 and 16 years of age. Blood samples were collected from 1000 students (423 boys and 577 girls) to determine fasting total cholesterol (TC), HDL and LDL cholesterol, and triglycerides (TG). The prevalence of dyslipidemia was established according to three definitions: those of the National Cholesterol Education Program (NCEP), the Brazilian Society of Cardiology (BSC), and the National Health and Nutrition Examination Survey (NHANES). Results: Significant differences (p<0.01) were found between the diagnostic criteria for TC (BSC 38.3%; NCEP 11.2%; NHANES 4.8%), HDL cholesterol (BSC 30.0%; NCEP 15.8% NHANES 18.4%), LDL cholesterol (BSC and NCEP 10.8% and NHANES 5.9%), and TG (BSC and NCEP 4.7% and NHANES 1.3%). The overall prevalence of dyslipidemia was 61% (BSC), 28.6% (NCEP) and 24.2% (NHANES). Agreement rates varied significantly (kappa 0.15–0.90). Conclusions: Although a high prevalence of dyslipidemia was observed in this study regardless of the diagnostic criteria used, the wide variation in rates highlights the need to establish a single definition with appropriate discriminatory power for adolescents. Resumo: Fundamento: O uso indiscriminado de diferentes critérios diagnósticos para a determinação de dislipidemias pode resultar em interpretações imprecisas, podendo comprometer o diagnóstico e, consequentemente, as ações terapêuticas e profiláticas a serem empregadas. Objetivo: Analisar possíveis diferenças nas taxas de prevalência de dislipidemias em adolescentes, com base em três critérios diagnósticos. Métodos: Estudo transversal conduzido com uma amostra representativa de adolescentes brasileiros de 11 a 16 anos. Amostras de sangue foram coletadas de 1000 escolares (423 rapazes e 577 moças) para determinação do colesterol total (CT), HDL, LDL e triglicérides (TG) em jejum. A prevalência de dislipidemias foi estabelecida com base em três critérios diagnósticos: National Cholesterol Education Program (NCEP), Sociedade Brasileira de Cardiologia (SBC) e National Health and Nutrition Examination Survey (NHANES). Resultados: Diferenças significantes (p<0,01) foram identificadas entre os critérios diagnósticos analisados para CT (SBC=38,3%; NCEP=11,2%; NHANES=4,8%), HDL (SBC=30,0%; NCEP=15,8%; NHANES=18,4%), LDL (SBC/NCEP=10,8% e NHANES=5,9%) e TG (SBC/NCEP=4,7% e NHANES=1,3%). No geral, a prevalência de dislipidemias foi na ordem de 61% (SBC); 28,6% (NCEP) e 24,2% (NHANES). Os índices de concordância variaram amplamente (Kappa=0,15 a 0,90). Conclusões: Embora uma elevada prevalência de dislipidemias tenha sido identificada neste estudo, independente dos critérios diagnósticos utilizados, a ampla variação nas taxas encontradas reforça a necessidade do estabelecimento de um critério único e com poder de discriminação adequado para adolescentes. Keywords: Risk factors, Cardiovascular disease, Atherosclerosis, Youth, Palavras-chave: Fatores de risco, Doenças cardiovasculares, Aterosclerose, Jovens |
| first_indexed | 2024-12-13T08:33:21Z |
| format | Article |
| id | doaj.art-1ee223c3a9cc4696b2076e807b392945 |
| institution | Directory Open Access Journal |
| issn | 0870-2551 |
| language | English |
| last_indexed | 2024-12-13T08:33:21Z |
| publishDate | 2015-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Revista Portuguesa de Cardiologia |
| spelling | doaj.art-1ee223c3a9cc4696b2076e807b3929452022-12-21T23:53:42ZengElsevierRevista Portuguesa de Cardiologia0870-25512015-02-01342103109Prevalence of dyslipidemia in adolescents: Comparison between definitionsCrisieli M. Tomeleri0Enio R.V. Ronque1Danilo R.P. Silva2Crivaldo G. Cardoso Júnior3Rômulo A. Fernandes4Denilson C. Teixeira5Décio S. Barbosa6Danielle Venturini7Alessandra M. Okino8Jair A. Oliveira9Edilson S. Cyrino10Study and Research Group in Metabolism, Nutrition, and Exercise GEPEMENE, State University of Londrina – UEL, Londrina, BrazilStudy and Research Group in Metabolism, Nutrition, and Exercise GEPEMENE, State University of Londrina – UEL, Londrina, BrazilStudy and Research Group in Metabolism, Nutrition, and Exercise GEPEMENE, State University of Londrina – UEL, Londrina, Brazil; Corresponding author.Study and Research Group in Metabolism, Nutrition, and Exercise GEPEMENE, State University of Londrina – UEL, Londrina, BrazilScientific Research Group Related to Physical Activity (GICRAF), Laboratory of Investigation in Exercise (LIVE), Department of Physical Education, Center of Sciences and Technology, UNESP Univ Estadual Paulista, Presidente Prudente, BrazilStudy and Research Group in Metabolism, Nutrition, and Exercise GEPEMENE, State University of Londrina – UEL, Londrina, BrazilDepartment of Pathology, Clinical and Toxicological Analysis, Center of Health Sciences, University Hospital, State University of Londrina – UEL, Londrina, BrazilDepartment of Pathology, Clinical and Toxicological Analysis, Center of Health Sciences, University Hospital, State University of Londrina – UEL, Londrina, BrazilDepartment of Pathology, Clinical and Toxicological Analysis, Center of Health Sciences, University Hospital, State University of Londrina – UEL, Londrina, BrazilDepartment of Pathology, Clinical and Toxicological Analysis, Center of Health Sciences, University Hospital, State University of Londrina – UEL, Londrina, BrazilStudy and Research Group in Metabolism, Nutrition, and Exercise GEPEMENE, State University of Londrina – UEL, Londrina, BrazilIntroduction: The indiscriminate use of different diagnostic criteria for the definition of dyslipidemia may result in inaccurate interpretations, which could compromise diagnosis and therefore the therapeutic and prophylactic actions to be taken. Objective: To analyze possible differences in prevalence rates of dyslipidemia in adolescents based on three diagnostic definitions. Methods: A cross-sectional study was conducted of a representative sample of Brazilian adolescents between 11 and 16 years of age. Blood samples were collected from 1000 students (423 boys and 577 girls) to determine fasting total cholesterol (TC), HDL and LDL cholesterol, and triglycerides (TG). The prevalence of dyslipidemia was established according to three definitions: those of the National Cholesterol Education Program (NCEP), the Brazilian Society of Cardiology (BSC), and the National Health and Nutrition Examination Survey (NHANES). Results: Significant differences (p<0.01) were found between the diagnostic criteria for TC (BSC 38.3%; NCEP 11.2%; NHANES 4.8%), HDL cholesterol (BSC 30.0%; NCEP 15.8% NHANES 18.4%), LDL cholesterol (BSC and NCEP 10.8% and NHANES 5.9%), and TG (BSC and NCEP 4.7% and NHANES 1.3%). The overall prevalence of dyslipidemia was 61% (BSC), 28.6% (NCEP) and 24.2% (NHANES). Agreement rates varied significantly (kappa 0.15–0.90). Conclusions: Although a high prevalence of dyslipidemia was observed in this study regardless of the diagnostic criteria used, the wide variation in rates highlights the need to establish a single definition with appropriate discriminatory power for adolescents. Resumo: Fundamento: O uso indiscriminado de diferentes critérios diagnósticos para a determinação de dislipidemias pode resultar em interpretações imprecisas, podendo comprometer o diagnóstico e, consequentemente, as ações terapêuticas e profiláticas a serem empregadas. Objetivo: Analisar possíveis diferenças nas taxas de prevalência de dislipidemias em adolescentes, com base em três critérios diagnósticos. Métodos: Estudo transversal conduzido com uma amostra representativa de adolescentes brasileiros de 11 a 16 anos. Amostras de sangue foram coletadas de 1000 escolares (423 rapazes e 577 moças) para determinação do colesterol total (CT), HDL, LDL e triglicérides (TG) em jejum. A prevalência de dislipidemias foi estabelecida com base em três critérios diagnósticos: National Cholesterol Education Program (NCEP), Sociedade Brasileira de Cardiologia (SBC) e National Health and Nutrition Examination Survey (NHANES). Resultados: Diferenças significantes (p<0,01) foram identificadas entre os critérios diagnósticos analisados para CT (SBC=38,3%; NCEP=11,2%; NHANES=4,8%), HDL (SBC=30,0%; NCEP=15,8%; NHANES=18,4%), LDL (SBC/NCEP=10,8% e NHANES=5,9%) e TG (SBC/NCEP=4,7% e NHANES=1,3%). No geral, a prevalência de dislipidemias foi na ordem de 61% (SBC); 28,6% (NCEP) e 24,2% (NHANES). Os índices de concordância variaram amplamente (Kappa=0,15 a 0,90). Conclusões: Embora uma elevada prevalência de dislipidemias tenha sido identificada neste estudo, independente dos critérios diagnósticos utilizados, a ampla variação nas taxas encontradas reforça a necessidade do estabelecimento de um critério único e com poder de discriminação adequado para adolescentes. Keywords: Risk factors, Cardiovascular disease, Atherosclerosis, Youth, Palavras-chave: Fatores de risco, Doenças cardiovasculares, Aterosclerose, Jovenshttp://www.sciencedirect.com/science/article/pii/S0870255115000050 |
| spellingShingle | Crisieli M. Tomeleri Enio R.V. Ronque Danilo R.P. Silva Crivaldo G. Cardoso Júnior Rômulo A. Fernandes Denilson C. Teixeira Décio S. Barbosa Danielle Venturini Alessandra M. Okino Jair A. Oliveira Edilson S. Cyrino Prevalence of dyslipidemia in adolescents: Comparison between definitions Revista Portuguesa de Cardiologia |
| title | Prevalence of dyslipidemia in adolescents: Comparison between definitions |
| title_full | Prevalence of dyslipidemia in adolescents: Comparison between definitions |
| title_fullStr | Prevalence of dyslipidemia in adolescents: Comparison between definitions |
| title_full_unstemmed | Prevalence of dyslipidemia in adolescents: Comparison between definitions |
| title_short | Prevalence of dyslipidemia in adolescents: Comparison between definitions |
| title_sort | prevalence of dyslipidemia in adolescents comparison between definitions |
| url | http://www.sciencedirect.com/science/article/pii/S0870255115000050 |
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