| Summary: | Colorectal cancer is increasing around the world, with many treatment modalities are used in the management of this disease, including surgery, radiotherapy and systemic therapy. The most common chemotherapy agents used in the treatment of colorectal cancer are 5-Fluourouracil (5-FU), Capecitabine, Oxaliplatin and Irinotecan. In this report, we describe a case of 56-year-old female with colorectal cancer and liver metastases who presented with intestinal obstruction and underwent urgent surgery, eight weeks after the surgery she started on chemotherapy XELOX (Capecitabine and Oxaliplatin), 10 days of the first cycle of chemotherapy she presented to emergency room with acrocyanosis, pain and paresthesia in her left hand. She had bluish discoloration of her fourth and fifth left digits, with absent ulnar and radial pulses, Doppler US revealed absence of blood flow. Urgent arterial thrombectomy performed. Then Oxaliplatin was omitted and patient continued her treatment without major sequela. This report demonstrates arterial thrombosis as a rare but serious complication that can occur with the use of Oxaliplatin in addition to Capecitabine.
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