Acute arterial thrombosis in a colon cancer patient after administration of oxaliplatin with capecitabine chemotherapy “case report”
Colorectal cancer is increasing around the world, with many treatment modalities are used in the management of this disease, including surgery, radiotherapy and systemic therapy. The most common chemotherapy agents used in the treatment of colorectal cancer are 5-Fluourouracil (5-FU), Capecitabine,...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Current Problems in Cancer: Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666621922000308 |
| _version_ | 1818230799972958208 |
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| author | Tala Alawabdeh Riyad T. Ellati Rula Amarin Walid Masoud Ramiz Abuhijlih |
| author_facet | Tala Alawabdeh Riyad T. Ellati Rula Amarin Walid Masoud Ramiz Abuhijlih |
| author_sort | Tala Alawabdeh |
| collection | DOAJ |
| description | Colorectal cancer is increasing around the world, with many treatment modalities are used in the management of this disease, including surgery, radiotherapy and systemic therapy. The most common chemotherapy agents used in the treatment of colorectal cancer are 5-Fluourouracil (5-FU), Capecitabine, Oxaliplatin and Irinotecan. In this report, we describe a case of 56-year-old female with colorectal cancer and liver metastases who presented with intestinal obstruction and underwent urgent surgery, eight weeks after the surgery she started on chemotherapy XELOX (Capecitabine and Oxaliplatin), 10 days of the first cycle of chemotherapy she presented to emergency room with acrocyanosis, pain and paresthesia in her left hand. She had bluish discoloration of her fourth and fifth left digits, with absent ulnar and radial pulses, Doppler US revealed absence of blood flow. Urgent arterial thrombectomy performed. Then Oxaliplatin was omitted and patient continued her treatment without major sequela. This report demonstrates arterial thrombosis as a rare but serious complication that can occur with the use of Oxaliplatin in addition to Capecitabine. |
| first_indexed | 2024-12-12T10:40:15Z |
| format | Article |
| id | doaj.art-1ee4ad8c2a784329b40b711472b4e0cc |
| institution | Directory Open Access Journal |
| issn | 2666-6219 |
| language | English |
| last_indexed | 2024-12-12T10:40:15Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Problems in Cancer: Case Reports |
| spelling | doaj.art-1ee4ad8c2a784329b40b711472b4e0cc2022-12-22T00:27:05ZengElsevierCurrent Problems in Cancer: Case Reports2666-62192022-06-016100166Acute arterial thrombosis in a colon cancer patient after administration of oxaliplatin with capecitabine chemotherapy “case report”Tala Alawabdeh0Riyad T. Ellati1Rula Amarin2Walid Masoud3Ramiz Abuhijlih4Department of Medical Oncology, King Hussein Cancer Center, Amman, Jordan; Corresponding author.Department of Plastic and Reconstructive Surgery, King Hussein Cancer Center, Amman, JordanDepartment of Medical Oncology, King Hussein Cancer Center, Amman, JordanDepartment of Plastic and Reconstructive Surgery, King Hussein Cancer Center, Amman, JordanDepartment of Radiation Oncology, King Hussein Cancer Center, Amman, JordanColorectal cancer is increasing around the world, with many treatment modalities are used in the management of this disease, including surgery, radiotherapy and systemic therapy. The most common chemotherapy agents used in the treatment of colorectal cancer are 5-Fluourouracil (5-FU), Capecitabine, Oxaliplatin and Irinotecan. In this report, we describe a case of 56-year-old female with colorectal cancer and liver metastases who presented with intestinal obstruction and underwent urgent surgery, eight weeks after the surgery she started on chemotherapy XELOX (Capecitabine and Oxaliplatin), 10 days of the first cycle of chemotherapy she presented to emergency room with acrocyanosis, pain and paresthesia in her left hand. She had bluish discoloration of her fourth and fifth left digits, with absent ulnar and radial pulses, Doppler US revealed absence of blood flow. Urgent arterial thrombectomy performed. Then Oxaliplatin was omitted and patient continued her treatment without major sequela. This report demonstrates arterial thrombosis as a rare but serious complication that can occur with the use of Oxaliplatin in addition to Capecitabine.http://www.sciencedirect.com/science/article/pii/S2666621922000308Colorectal cancerOxaliplatinCapecitabineArterial thrombosisCase report |
| spellingShingle | Tala Alawabdeh Riyad T. Ellati Rula Amarin Walid Masoud Ramiz Abuhijlih Acute arterial thrombosis in a colon cancer patient after administration of oxaliplatin with capecitabine chemotherapy “case report” Current Problems in Cancer: Case Reports Colorectal cancer Oxaliplatin Capecitabine Arterial thrombosis Case report |
| title | Acute arterial thrombosis in a colon cancer patient after administration of oxaliplatin with capecitabine chemotherapy “case report” |
| title_full | Acute arterial thrombosis in a colon cancer patient after administration of oxaliplatin with capecitabine chemotherapy “case report” |
| title_fullStr | Acute arterial thrombosis in a colon cancer patient after administration of oxaliplatin with capecitabine chemotherapy “case report” |
| title_full_unstemmed | Acute arterial thrombosis in a colon cancer patient after administration of oxaliplatin with capecitabine chemotherapy “case report” |
| title_short | Acute arterial thrombosis in a colon cancer patient after administration of oxaliplatin with capecitabine chemotherapy “case report” |
| title_sort | acute arterial thrombosis in a colon cancer patient after administration of oxaliplatin with capecitabine chemotherapy case report |
| topic | Colorectal cancer Oxaliplatin Capecitabine Arterial thrombosis Case report |
| url | http://www.sciencedirect.com/science/article/pii/S2666621922000308 |
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