Cerebral vasculitis due to Aspergillus spp. in immunocompromised patients: literature review

Cerebral vasculitis due to Aspergillus spp. in immunocompromised patients: literature review

Objectives: Invasive aspergillosis is a threat for immunocompromised patients. We present a case series of aggressive cerebral vasculitis caused by Aspergillus spp. infection in immunocompromised patients. Methods: We present a retrospective case series of three autopsy-proven invasive cerebral aspe...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Elie Haddad, Arnaud Fekkar, Sophie Bonnin, Natalia Shor, Danielle Seilhean, Isabelle Plu, Valérie Touitou, Véronique Leblond, Nicolas Weiss, Sophie Demeret, Valérie Pourcher
Format: Artikel
Sprache:English
Veröffentlicht: Elsevier 2022-09-01
Schriftenreihe:International Journal of Infectious Diseases
Schlagworte:
Aspergillosis
Fungal
Vasculitis
Cerebral infarction
Meningitis
Online Zugang:http://www.sciencedirect.com/science/article/pii/S1201971222003216
Beschreibung
Zusammenfassung:Objectives: Invasive aspergillosis is a threat for immunocompromised patients. We present a case series of aggressive cerebral vasculitis caused by Aspergillus spp. infection in immunocompromised patients. Methods: We present a retrospective case series of three autopsy-proven invasive cerebral aspergillosis with diffuse vasculitis affecting large caliber cerebral vessels. Results: Three patients were immunosuppressed: one on rituximab, one on corticosteroids, and one with a renal transplant. Two of these patients were diagnosed with cerebral aspergillosis on postmortem. Conclusion: Aspergillus cerebral vasculitis is a rare form of invasive aspergillosis that should be considered in an immunocompromised individual with suggestive lesions on imaging. It should be suspected as a possible cause of aseptic neutrophil meningitis.
ISSN:1201-9712

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