Effects of 4′-Demethylnobiletin and 4′-Demethyltangeretin on Osteoclast Differentiation In Vitro and in a Mouse Model of Estrogen-Deficient Bone Resorption

Effects of 4′-Demethylnobiletin and 4′-Demethyltangeretin on Osteoclast Differentiation In Vitro and in a Mouse Model of Estrogen-Deficient Bone Resorption

Citrus nobiletin (NOB) and tangeretin (TAN) show protective effects against disease-related bone destruction. We achieved demethylation of NOB and TAN into 4′-demethylnobiletin (4′-DN) and 4′-demethyltangeretin (4′-DT) using enzyme-manufacturing methods. In this study, we examined the effects of 4′-...

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Bibliographic Details
Main Authors: Michiko Hirata, Tsukasa Tominari, Ryota Ichimaru, Naruhiko Takiguchi, Yuki Tanaka, Masaru Takatoya, Daichi Arai, Shosei Yoshinouchi, Chisato Miyaura, Chiho Matsumoto, Sihui Ma, Katsuhiko Suzuki, Florian M. W. Grundler, Masaki Inada
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Nutrients
Subjects:
4′-demethylnobiletin
4′-demethyltangeretin
osteoclast
postmenopausal osteoporosis
Online Access:https://www.mdpi.com/2072-6643/15/6/1403

Internet

https://www.mdpi.com/2072-6643/15/6/1403

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