The efficacy of prophylactic metoclopramide in preventing nausea and vomiting in patients with acute pain treated with intravenous tramadol: a randomized double-blinded, placebo-controlled trial
Abstract Objective To examine the clinical efficacy of prophylactic metoclopramide in reducing the incidence of nausea and vomiting in emergency department (ED) patients with acute pain who were treated with intravenous tramadol. Results We conducted a single-center randomized, double-blinded, place...
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | BMC Research Notes |
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| Online Access: | https://doi.org/10.1186/s13104-023-06395-y |
| _version_ | 1797769688235638784 |
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| author | Haruethai Sriwiset Thanin Lokeskrawee Jayanton Patumanond Pakpoom Wongyikul Phichayut Phinyo |
| author_facet | Haruethai Sriwiset Thanin Lokeskrawee Jayanton Patumanond Pakpoom Wongyikul Phichayut Phinyo |
| author_sort | Haruethai Sriwiset |
| collection | DOAJ |
| description | Abstract Objective To examine the clinical efficacy of prophylactic metoclopramide in reducing the incidence of nausea and vomiting in emergency department (ED) patients with acute pain who were treated with intravenous tramadol. Results We conducted a single-center randomized, double-blinded, placebo-controlled trial. A total of 99 ED patients presented with acute pain were recruited. Sixty-four patients were randomized, 31 patients in the treatment arm and 33 in the control arm. Overall, there were no significant differences in baseline characteristics between treatment arm and control arm. Only one patient within each arm reported having nausea symptom. No patients reported vomiting episode. There was no statistically significant difference in the proportion of patients with nausea or vomiting symptoms between the two groups (3.2% in the treatment arm vs. 3.0% in the control arm, p = 1.000). The administration of prophylactic metoclopramide may not provide additional benefit in reducing the occurrence of nausea and/or vomiting episode in ED patients with acute pain treated with intravenous tramadol. Trial registration Randomized clinical trial TCTR20220525001; registration date: 21 October 2021. Retrospectively registered. |
| first_indexed | 2024-03-12T21:11:37Z |
| format | Article |
| id | doaj.art-1ee8ac82de1946b082730b81138df226 |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-03-12T21:11:37Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-1ee8ac82de1946b082730b81138df2262023-07-30T11:06:33ZengBMCBMC Research Notes1756-05002023-07-011611610.1186/s13104-023-06395-yThe efficacy of prophylactic metoclopramide in preventing nausea and vomiting in patients with acute pain treated with intravenous tramadol: a randomized double-blinded, placebo-controlled trialHaruethai Sriwiset0Thanin Lokeskrawee1Jayanton Patumanond2Pakpoom Wongyikul3Phichayut Phinyo4Department of Emergency Medicine, Lampang HospitalDepartment of Emergency Medicine, Lampang HospitalCenter for Clinical Epidemiology and Clinical Statistics, Faculty of Medicine, Chiang Mai UniversityCenter for Clinical Epidemiology and Clinical Statistics, Faculty of Medicine, Chiang Mai UniversityDepartment of Family Medicine, Center for Clinical Epidemiology and Clinical Statistics, Musculoskeletal Science and Translational Research, Faculty of Medicine, Chiang Mai UniversityAbstract Objective To examine the clinical efficacy of prophylactic metoclopramide in reducing the incidence of nausea and vomiting in emergency department (ED) patients with acute pain who were treated with intravenous tramadol. Results We conducted a single-center randomized, double-blinded, placebo-controlled trial. A total of 99 ED patients presented with acute pain were recruited. Sixty-four patients were randomized, 31 patients in the treatment arm and 33 in the control arm. Overall, there were no significant differences in baseline characteristics between treatment arm and control arm. Only one patient within each arm reported having nausea symptom. No patients reported vomiting episode. There was no statistically significant difference in the proportion of patients with nausea or vomiting symptoms between the two groups (3.2% in the treatment arm vs. 3.0% in the control arm, p = 1.000). The administration of prophylactic metoclopramide may not provide additional benefit in reducing the occurrence of nausea and/or vomiting episode in ED patients with acute pain treated with intravenous tramadol. Trial registration Randomized clinical trial TCTR20220525001; registration date: 21 October 2021. Retrospectively registered.https://doi.org/10.1186/s13104-023-06395-yAnalgesics opioidOpioid induce nausea and vomitingRandomized controlled trialTramadolMetoclopramide |
| spellingShingle | Haruethai Sriwiset Thanin Lokeskrawee Jayanton Patumanond Pakpoom Wongyikul Phichayut Phinyo The efficacy of prophylactic metoclopramide in preventing nausea and vomiting in patients with acute pain treated with intravenous tramadol: a randomized double-blinded, placebo-controlled trial BMC Research Notes Analgesics opioid Opioid induce nausea and vomiting Randomized controlled trial Tramadol Metoclopramide |
| title | The efficacy of prophylactic metoclopramide in preventing nausea and vomiting in patients with acute pain treated with intravenous tramadol: a randomized double-blinded, placebo-controlled trial |
| title_full | The efficacy of prophylactic metoclopramide in preventing nausea and vomiting in patients with acute pain treated with intravenous tramadol: a randomized double-blinded, placebo-controlled trial |
| title_fullStr | The efficacy of prophylactic metoclopramide in preventing nausea and vomiting in patients with acute pain treated with intravenous tramadol: a randomized double-blinded, placebo-controlled trial |
| title_full_unstemmed | The efficacy of prophylactic metoclopramide in preventing nausea and vomiting in patients with acute pain treated with intravenous tramadol: a randomized double-blinded, placebo-controlled trial |
| title_short | The efficacy of prophylactic metoclopramide in preventing nausea and vomiting in patients with acute pain treated with intravenous tramadol: a randomized double-blinded, placebo-controlled trial |
| title_sort | efficacy of prophylactic metoclopramide in preventing nausea and vomiting in patients with acute pain treated with intravenous tramadol a randomized double blinded placebo controlled trial |
| topic | Analgesics opioid Opioid induce nausea and vomiting Randomized controlled trial Tramadol Metoclopramide |
| url | https://doi.org/10.1186/s13104-023-06395-y |
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