Antibacterial and antifungal properties of guanylhydrazones
A series of novel guanylhydrazones were designed, synthesized and characterized. All the compounds were screened for their antibacterial and antifungal activity. Compounds 26 and 27 showed excellent antibacterial activities against Staphylococcus aureus ATCC 25923 and Micrococcus luteus ATCC 379 wit...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2017-01-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2017/0352-51391700033A.pdf |
| _version_ | 1828773351013744640 |
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| author | Ajdačić Vladimir Lazić Jelena Mojićević Marija Šegan Sandra Nikodinović-Runić Jasmina Opsenica Igor M. |
| author_facet | Ajdačić Vladimir Lazić Jelena Mojićević Marija Šegan Sandra Nikodinović-Runić Jasmina Opsenica Igor M. |
| author_sort | Ajdačić Vladimir |
| collection | DOAJ |
| description | A series of novel guanylhydrazones were designed, synthesized and characterized. All the compounds were screened for their antibacterial and antifungal activity. Compounds 26 and 27 showed excellent antibacterial activities against Staphylococcus aureus ATCC 25923 and Micrococcus luteus ATCC 379 with minimal inhibitory concentrations of 4 μg mL-1, and good antifungal activity against Candida parapsilosis ATCC 22019. These results suggested that the selected guanylhydrazones could serve as promising leads for improved antimicrobial development. [Project of the Ministry of
Education, Science and Technological Development of the Republic of Serbia,
Grant No. 172008 and Grant No. 173048] |
| first_indexed | 2024-12-11T15:01:55Z |
| format | Article |
| id | doaj.art-1ee9d51ee23f4396bd005df1b09fe025 |
| institution | Directory Open Access Journal |
| issn | 0352-5139 1820-7421 |
| language | English |
| last_indexed | 2024-12-11T15:01:55Z |
| publishDate | 2017-01-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-1ee9d51ee23f4396bd005df1b09fe0252022-12-22T01:01:06ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51391820-74212017-01-0182664164910.2298/JSC170213033A0352-51391700033AAntibacterial and antifungal properties of guanylhydrazonesAjdačić Vladimir0Lazić Jelena1Mojićević Marija2Šegan Sandra3Nikodinović-Runić Jasmina4Opsenica Igor M.5Faculty of Chemistry, BelgradeFaculty of Chemistry, BelgradeInstitute of Molecular Genetics and Genetic Engineering, BelgradeInstitute of Chemistry, Technology, and Metallurgy, BelgradeInstitute of Molecular Genetics and Genetic Engineering, BelgradeFaculty of Chemistry, BelgradeA series of novel guanylhydrazones were designed, synthesized and characterized. All the compounds were screened for their antibacterial and antifungal activity. Compounds 26 and 27 showed excellent antibacterial activities against Staphylococcus aureus ATCC 25923 and Micrococcus luteus ATCC 379 with minimal inhibitory concentrations of 4 μg mL-1, and good antifungal activity against Candida parapsilosis ATCC 22019. These results suggested that the selected guanylhydrazones could serve as promising leads for improved antimicrobial development. [Project of the Ministry of Education, Science and Technological Development of the Republic of Serbia, Grant No. 172008 and Grant No. 173048]http://www.doiserbia.nb.rs/img/doi/0352-5139/2017/0352-51391700033A.pdfguanylhydrazonesiminoguanidinesantibacterial activityantifungal activityCandida spp. |
| spellingShingle | Ajdačić Vladimir Lazić Jelena Mojićević Marija Šegan Sandra Nikodinović-Runić Jasmina Opsenica Igor M. Antibacterial and antifungal properties of guanylhydrazones Journal of the Serbian Chemical Society guanylhydrazones iminoguanidines antibacterial activity antifungal activity Candida spp. |
| title | Antibacterial and antifungal properties of guanylhydrazones |
| title_full | Antibacterial and antifungal properties of guanylhydrazones |
| title_fullStr | Antibacterial and antifungal properties of guanylhydrazones |
| title_full_unstemmed | Antibacterial and antifungal properties of guanylhydrazones |
| title_short | Antibacterial and antifungal properties of guanylhydrazones |
| title_sort | antibacterial and antifungal properties of guanylhydrazones |
| topic | guanylhydrazones iminoguanidines antibacterial activity antifungal activity Candida spp. |
| url | http://www.doiserbia.nb.rs/img/doi/0352-5139/2017/0352-51391700033A.pdf |
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