Spinning magnetic field patterns that cause oncolysis by oxidative stress in glioma cells
Abstract Raising reactive oxygen species (ROS) levels in cancer cells to cause macromolecular damage and cell death is a promising anticancer treatment strategy. Observations that electromagnetic fields (EMF) elevate intracellular ROS and cause cancer cell death, have led us to develop a new portabl...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-46758-w |
| _version_ | 1797630288785833984 |
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| author | Shashank Hambarde Jeanne M. Manalo David S. Baskin Martyn A. Sharpe Santosh A. Helekar |
| author_facet | Shashank Hambarde Jeanne M. Manalo David S. Baskin Martyn A. Sharpe Santosh A. Helekar |
| author_sort | Shashank Hambarde |
| collection | DOAJ |
| description | Abstract Raising reactive oxygen species (ROS) levels in cancer cells to cause macromolecular damage and cell death is a promising anticancer treatment strategy. Observations that electromagnetic fields (EMF) elevate intracellular ROS and cause cancer cell death, have led us to develop a new portable wearable EMF device that generates spinning oscillating magnetic fields (sOMF) to selectively kill cancer cells while sparing normal cells in vitro and to shrink GBM tumors in vivo through a novel mechanism. Here, we characterized the precise configurations and timings of sOMF stimulation that produce cytotoxicity due to a critical rise in superoxide in two types of human glioma cells. We also found that the antioxidant Trolox reverses the cytotoxic effect of sOMF on glioma cells indicating that ROS play a causal role in producing the effect. Our findings clarify the link between the physics of magnetic stimulation and its mechanism of anticancer action, facilitating the development of a potential new safe noninvasive device-based treatment for GBM and other gliomas. |
| first_indexed | 2024-03-11T11:05:03Z |
| format | Article |
| id | doaj.art-1eea8afbc7594db7b7c3e6e92a0e0004 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-11T11:05:03Z |
| publishDate | 2023-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-1eea8afbc7594db7b7c3e6e92a0e00042023-11-12T12:13:55ZengNature PortfolioScientific Reports2045-23222023-11-0113111310.1038/s41598-023-46758-wSpinning magnetic field patterns that cause oncolysis by oxidative stress in glioma cellsShashank Hambarde0Jeanne M. Manalo1David S. Baskin2Martyn A. Sharpe3Santosh A. Helekar4Kenneth R. Peak Center for Brain and Pituitary Tumor Treatment and Research, Houston Methodist HospitalKenneth R. Peak Center for Brain and Pituitary Tumor Treatment and Research, Houston Methodist HospitalKenneth R. Peak Center for Brain and Pituitary Tumor Treatment and Research, Houston Methodist HospitalKenneth R. Peak Center for Brain and Pituitary Tumor Treatment and Research, Houston Methodist HospitalKenneth R. Peak Center for Brain and Pituitary Tumor Treatment and Research, Houston Methodist HospitalAbstract Raising reactive oxygen species (ROS) levels in cancer cells to cause macromolecular damage and cell death is a promising anticancer treatment strategy. Observations that electromagnetic fields (EMF) elevate intracellular ROS and cause cancer cell death, have led us to develop a new portable wearable EMF device that generates spinning oscillating magnetic fields (sOMF) to selectively kill cancer cells while sparing normal cells in vitro and to shrink GBM tumors in vivo through a novel mechanism. Here, we characterized the precise configurations and timings of sOMF stimulation that produce cytotoxicity due to a critical rise in superoxide in two types of human glioma cells. We also found that the antioxidant Trolox reverses the cytotoxic effect of sOMF on glioma cells indicating that ROS play a causal role in producing the effect. Our findings clarify the link between the physics of magnetic stimulation and its mechanism of anticancer action, facilitating the development of a potential new safe noninvasive device-based treatment for GBM and other gliomas.https://doi.org/10.1038/s41598-023-46758-w |
| spellingShingle | Shashank Hambarde Jeanne M. Manalo David S. Baskin Martyn A. Sharpe Santosh A. Helekar Spinning magnetic field patterns that cause oncolysis by oxidative stress in glioma cells Scientific Reports |
| title | Spinning magnetic field patterns that cause oncolysis by oxidative stress in glioma cells |
| title_full | Spinning magnetic field patterns that cause oncolysis by oxidative stress in glioma cells |
| title_fullStr | Spinning magnetic field patterns that cause oncolysis by oxidative stress in glioma cells |
| title_full_unstemmed | Spinning magnetic field patterns that cause oncolysis by oxidative stress in glioma cells |
| title_short | Spinning magnetic field patterns that cause oncolysis by oxidative stress in glioma cells |
| title_sort | spinning magnetic field patterns that cause oncolysis by oxidative stress in glioma cells |
| url | https://doi.org/10.1038/s41598-023-46758-w |
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